Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096597310> ?p ?o ?g. }
- W2096597310 endingPage "278" @default.
- W2096597310 startingPage "268" @default.
- W2096597310 abstract "Silica and asbestos cause pneumoconioses known as silicosis and asbestosis, respectively, that are each characterized by progressive pulmonary fibrosis. While local effects of inhaled silica particles alter the function of alveolar macrophages and sequential cellular and molecular biological events, general systemic immunological effects may also evolve. One well-known health outcome associated with silica exposure/silicosis is an increase in the incidence of autoimmune disorders. In addition, while exposure to silica—in the crystalline form—has also been seen to be associated with the development of lung cancers, it remains unclear as to whether or not silicosis is a necessary condition for the elevation of silica-associated lung cancer risks. Since asbestos is a mineral silicate, it would be expected to also possess generalized immunotoxicological effects similar to those associated with silica particles. However, asbestos-exposed patients are far better known than silicotic patients for development of malignant diseases such as lung cancer and mesothelioma, and less so for the development of autoimmune disorders. With both asbestos and crystalline silica, one important dysregulatory outcome that needs to be considered is an alteration in tumor immunity that allows for silica- or asbestos- (or asbestos-associated agent)-induced tumors to survive and thrive in situ. In this review, the immunotoxicological effects of both silica and asbestos are presented and contrasted in terms of their abilities to induce immune system dysregulation that then are manifest by the onset of autoimmunity or by alterations in host-tumor immunity." @default.
- W2096597310 created "2016-06-24" @default.
- W2096597310 creator A5001986222 @default.
- W2096597310 creator A5013014848 @default.
- W2096597310 creator A5013331184 @default.
- W2096597310 creator A5020982818 @default.
- W2096597310 creator A5030628435 @default.
- W2096597310 creator A5057275240 @default.
- W2096597310 creator A5059615532 @default.
- W2096597310 creator A5078811296 @default.
- W2096597310 creator A5087992950 @default.
- W2096597310 creator A5090560877 @default.
- W2096597310 date "2010-09-20" @default.
- W2096597310 modified "2023-10-09" @default.
- W2096597310 title "Dysregulation of the immune system caused by silica and asbestos" @default.
- W2096597310 cites W170992045 @default.
- W2096597310 cites W1784595984 @default.
- W2096597310 cites W1878591306 @default.
- W2096597310 cites W1964129681 @default.
- W2096597310 cites W1964288721 @default.
- W2096597310 cites W1971128480 @default.
- W2096597310 cites W1971622089 @default.
- W2096597310 cites W1975078601 @default.
- W2096597310 cites W1977496118 @default.
- W2096597310 cites W1984271514 @default.
- W2096597310 cites W1991212304 @default.
- W2096597310 cites W1992147654 @default.
- W2096597310 cites W1992913869 @default.
- W2096597310 cites W1993199753 @default.
- W2096597310 cites W1993493586 @default.
- W2096597310 cites W1993580143 @default.
- W2096597310 cites W1996868157 @default.
- W2096597310 cites W2004708987 @default.
- W2096597310 cites W2005781953 @default.
- W2096597310 cites W2010369905 @default.
- W2096597310 cites W2012394031 @default.
- W2096597310 cites W2014447838 @default.
- W2096597310 cites W2019802642 @default.
- W2096597310 cites W2022163946 @default.
- W2096597310 cites W2024896551 @default.
- W2096597310 cites W2028111124 @default.
- W2096597310 cites W2030915036 @default.
- W2096597310 cites W2031005891 @default.
- W2096597310 cites W2035913853 @default.
- W2096597310 cites W2038645381 @default.
- W2096597310 cites W2039983193 @default.
- W2096597310 cites W2040006797 @default.
- W2096597310 cites W2040361508 @default.
- W2096597310 cites W2040678840 @default.
- W2096597310 cites W2044353844 @default.
- W2096597310 cites W2046998600 @default.
- W2096597310 cites W2048021140 @default.
- W2096597310 cites W2050689714 @default.
- W2096597310 cites W2051092473 @default.
- W2096597310 cites W2053226799 @default.
- W2096597310 cites W2055312560 @default.
- W2096597310 cites W2057402471 @default.
- W2096597310 cites W2060221887 @default.
- W2096597310 cites W2061262594 @default.
- W2096597310 cites W2065413461 @default.
- W2096597310 cites W2066526517 @default.
- W2096597310 cites W2070280945 @default.
- W2096597310 cites W2071151379 @default.
- W2096597310 cites W2072063893 @default.
- W2096597310 cites W2072484350 @default.
- W2096597310 cites W2073317648 @default.
- W2096597310 cites W2078319346 @default.
- W2096597310 cites W2083873825 @default.
- W2096597310 cites W2084957243 @default.
- W2096597310 cites W2085601342 @default.
- W2096597310 cites W2087632217 @default.
- W2096597310 cites W2088093865 @default.
- W2096597310 cites W2089733374 @default.
- W2096597310 cites W2090067693 @default.
- W2096597310 cites W2091294089 @default.
- W2096597310 cites W2102332546 @default.
- W2096597310 cites W2108158680 @default.
- W2096597310 cites W2110839294 @default.
- W2096597310 cites W2111464100 @default.
- W2096597310 cites W2116650911 @default.
- W2096597310 cites W2118017831 @default.
- W2096597310 cites W2122722718 @default.
- W2096597310 cites W2128175147 @default.
- W2096597310 cites W2128421447 @default.
- W2096597310 cites W2132524122 @default.
- W2096597310 cites W2134756173 @default.
- W2096597310 cites W2150921683 @default.
- W2096597310 cites W2152508168 @default.
- W2096597310 cites W2152575655 @default.
- W2096597310 cites W2156305166 @default.
- W2096597310 cites W2157099277 @default.
- W2096597310 cites W2161798949 @default.
- W2096597310 cites W2163283585 @default.
- W2096597310 cites W2163484167 @default.
- W2096597310 cites W2167616228 @default.
- W2096597310 cites W2168000965 @default.
- W2096597310 cites W2250273225 @default.
- W2096597310 cites W2267841716 @default.