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• W2096597599 abstract "A nonrandomized trial was undertaken to evaluate the combination of didanosine and interferon-alpha (INF-alpha) in human immunodeficiency virus (HIV)-infected patients. Thirty-six volunteers with >200 x 10(6) CD4 cells/L received didanosine (one 100-, 250-, or 375-mg sachet twice daily) for at least 6 weeks, following which IFN-alpha (1, 5, 10, or 15 MU/day) was begun. Didanosine (one 375-mg sachet twice daily) was substituted for zidovudine in 14 additional patients who had received IFN-alpha and zidovudine for 7-45 months. Thirty-five patients completed the 34-week study. Clinical or chemical pancreatitis was the most common (6 patients) dose-limiting toxicity. CD4 cell counts increased with didanosine but declined following the addition of IFN-alpha; CD4 cell percents tended to increase and remain elevated. Thus, combination therapy with didanosine and IFN-alpha can be safely administered to patients with HIV infection. The clinical benefit of this combination therapy will require further evaluation." @default.
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• W2096597599 date "1996-04-01" @default.
• W2096597599 modified "2023-09-27" @default.
• W2096597599 title "Combination Therapy with Didanosine and Interferon-a in Human Immunodeficiency Virus-Infected Patients: Results of a Phase I/II Trial" @default.
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• W2096597599 doi "https://doi.org/10.1093/infdis/173.4.840" @default.
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