Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096630975> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2096630975 endingPage "75" @default.
- W2096630975 startingPage "69" @default.
- W2096630975 abstract "Febuxostat is a novel non-purine selective inhibitor of xanthine oxidase being developed for the management of hyperuricaemia in patients with gout. To critically review the clinical trial data, safety profile, pharmacology, and role of febuxostat for the treatment of hyperuricemia and gout. A review of the literatures on febuxostat was performed. All available human studies describing the pharmacology of febuxostat were included; including pharmacodynamics, efficacy, and safety of febuxostat. Available studies, patents and abstracts were identified through PubMed (1990-December 2006), Delphion, Cochrane Databases, and the American College of Rheumatology and European League Against Rheumatism Web sites. Key search terms were febuxostat, TMX- 67, and TEI-6720. Febuxostat has been used at a dose of 80 to 120 mg for the management of hyperuricemia in gout. The drug is mainly metabolized by the liver and therefore mild-moderate renal impairment does not appear to impede its effect. However, given the limited long-term liver function safety data, failure of a large percentage of patients taking febuxostat to achieve the primary end point of serum urate levels less than 6.0 mg/dL, and higher drop out rate in the Febuxostat group in the clinical trials, the exact role of febuxostat as a urate-lowering therapy remains uncertain. Febuxostat is a promising alternative to allopurinol for the treatment of gout and hyperuricemia. The optimal length of colchicines prophylactic therapy for chronic gout, clinical significance of abnormal liver function tests results during therapy, and safety in patients with moderate or severe hepatic and renal insufficiency warrant further investigation. A post-market surveillance is also needed to address the safety issue of long-term febuxostat treatment. Keywords: Febuxostat, gout, hyperuricemia, uric acid, allopurinol, treatment" @default.
- W2096630975 created "2016-06-24" @default.
- W2096630975 creator A5055536763 @default.
- W2096630975 date "2007-02-01" @default.
- W2096630975 modified "2023-09-25" @default.
- W2096630975 title "Febuxostat: A Novel Non-Purine Selective Inhibitor of Xanthine Oxidase for the Treatment of Hyperuricemia in Gout" @default.
- W2096630975 cites W1564333578 @default.
- W2096630975 cites W1988110621 @default.
- W2096630975 cites W1990212288 @default.
- W2096630975 cites W2003407110 @default.
- W2096630975 cites W2011487877 @default.
- W2096630975 cites W2020033798 @default.
- W2096630975 cites W2020247068 @default.
- W2096630975 cites W2071386060 @default.
- W2096630975 cites W2073496185 @default.
- W2096630975 cites W2086544233 @default.
- W2096630975 cites W2098144815 @default.
- W2096630975 cites W2110393515 @default.
- W2096630975 cites W2119515450 @default.
- W2096630975 cites W2121150699 @default.
- W2096630975 cites W2154564423 @default.
- W2096630975 cites W2156131531 @default.
- W2096630975 cites W81458220 @default.
- W2096630975 doi "https://doi.org/10.2174/187221307779815020" @default.
- W2096630975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19075968" @default.
- W2096630975 hasPublicationYear "2007" @default.
- W2096630975 type Work @default.
- W2096630975 sameAs 2096630975 @default.
- W2096630975 citedByCount "45" @default.
- W2096630975 countsByYear W20966309752012 @default.
- W2096630975 countsByYear W20966309752013 @default.
- W2096630975 countsByYear W20966309752014 @default.
- W2096630975 countsByYear W20966309752015 @default.
- W2096630975 countsByYear W20966309752017 @default.
- W2096630975 countsByYear W20966309752018 @default.
- W2096630975 countsByYear W20966309752019 @default.
- W2096630975 countsByYear W20966309752020 @default.
- W2096630975 countsByYear W20966309752021 @default.
- W2096630975 countsByYear W20966309752022 @default.
- W2096630975 countsByYear W20966309752023 @default.
- W2096630975 crossrefType "journal-article" @default.
- W2096630975 hasAuthorship W2096630975A5055536763 @default.
- W2096630975 hasConcept C126322002 @default.
- W2096630975 hasConcept C181199279 @default.
- W2096630975 hasConcept C185592680 @default.
- W2096630975 hasConcept C2777820942 @default.
- W2096630975 hasConcept C2778102346 @default.
- W2096630975 hasConcept C2779721657 @default.
- W2096630975 hasConcept C2779881121 @default.
- W2096630975 hasConcept C2780261098 @default.
- W2096630975 hasConcept C2780402116 @default.
- W2096630975 hasConcept C2780932893 @default.
- W2096630975 hasConcept C55493867 @default.
- W2096630975 hasConcept C71924100 @default.
- W2096630975 hasConcept C98274493 @default.
- W2096630975 hasConceptScore W2096630975C126322002 @default.
- W2096630975 hasConceptScore W2096630975C181199279 @default.
- W2096630975 hasConceptScore W2096630975C185592680 @default.
- W2096630975 hasConceptScore W2096630975C2777820942 @default.
- W2096630975 hasConceptScore W2096630975C2778102346 @default.
- W2096630975 hasConceptScore W2096630975C2779721657 @default.
- W2096630975 hasConceptScore W2096630975C2779881121 @default.
- W2096630975 hasConceptScore W2096630975C2780261098 @default.
- W2096630975 hasConceptScore W2096630975C2780402116 @default.
- W2096630975 hasConceptScore W2096630975C2780932893 @default.
- W2096630975 hasConceptScore W2096630975C55493867 @default.
- W2096630975 hasConceptScore W2096630975C71924100 @default.
- W2096630975 hasConceptScore W2096630975C98274493 @default.
- W2096630975 hasIssue "1" @default.
- W2096630975 hasLocation W20966309751 @default.
- W2096630975 hasLocation W20966309752 @default.
- W2096630975 hasOpenAccess W2096630975 @default.
- W2096630975 hasPrimaryLocation W20966309751 @default.
- W2096630975 hasRelatedWork W1966731608 @default.
- W2096630975 hasRelatedWork W1980128156 @default.
- W2096630975 hasRelatedWork W2016825263 @default.
- W2096630975 hasRelatedWork W2163725434 @default.
- W2096630975 hasRelatedWork W2394470303 @default.
- W2096630975 hasRelatedWork W2423434425 @default.
- W2096630975 hasRelatedWork W2538925267 @default.
- W2096630975 hasRelatedWork W2765766885 @default.
- W2096630975 hasRelatedWork W3125591798 @default.
- W2096630975 hasRelatedWork W4292196777 @default.
- W2096630975 hasVolume "1" @default.
- W2096630975 isParatext "false" @default.
- W2096630975 isRetracted "false" @default.
- W2096630975 magId "2096630975" @default.
- W2096630975 workType "article" @default.