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• W2096661621 abstract "▪ Abstract X-linked severe combined immunodeficiency (XSCID) is an inherited disease characterized by profoundly diminished cell-mediated and humoral immunity. XSCID was found to result from mutations in the interleukin-2 (IL-2) receptor γchain. Knowledge of the genetic defect has important implications for prenatal and postnatal diagnosis, carrier female identification, and the possibility of gene therapy. The fact that the phenotype and clinical manifestations in XSCID are more severe than the abnormalities found in humans or mice deficient in IL-2 led to the speculation and subsequent confirmation that the IL-2 receptor is not the only receptor to contain the γ chain. Instead, the γ chain is also a component of the receptors for IL-4, IL-7, IL- 9, and IL-15 and is now denoted as the common cytokine receptor γ chain, γ c . The role of γ c in signaling and lymphoid development and the implications of a shared receptor component are discussed." @default.
• W2096661621 created "2016-06-24" @default.
• W2096661621 creator A5005337631 @default.
• W2096661621 date "1996-02-01" @default.
• W2096661621 modified "2023-09-27" @default.
• W2096661621 title "THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling" @default.
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• W2096661621 doi "https://doi.org/10.1146/annurev.med.47.1.229" @default.
• W2096661621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8712778" @default.
• W2096661621 hasPublicationYear "1996" @default.
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