Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096669314> ?p ?o ?g. }
- W2096669314 endingPage "101" @default.
- W2096669314 startingPage "81" @default.
- W2096669314 abstract "Introduction: Combination antiretroviral therapy has markedly improved the survival rate and quality of life in patients infected with HIV due to the powerful suppressor effect that current antiretroviral drugs have on the viral load. Consequently, the immune system undergoes a substantial qualitative and quantitative improvement; and this leads to an increase in the absolute CD4+ T-lymphocyte count and the restoration of lost T-cell responses against certain opportunistic pathogens. Unfortunately, not all patients who successfully suppress plasma viremia experience sufficient CD4+ T-cell gain and these patients, in turn, are associated with worse outcomes. Pharmacogenetic studies have been used to investigate how a patient's genetic predisposition may affect their response to antiretroviral drugs. Areas covered: This article reviews the investigations that have been published on the association between host genetic determinants of CD4+ T-cell gain in treated HIV-infected patients. Studies were identified through a PubMed database search. Longitudinal studies into pharmacogenetic association were specifically selected. Expert opinion: While the possibility of genetic predisposition to HIV therapeutics has potential, most studies provide inconsistent data. Inconsistency is often due to partial genetic evaluation, different categorization of poor immune recovery or due to small numbers of patients evaluated. Currently, studies still belong to the research laboratory stage and more studies are required to improve our understanding." @default.
- W2096669314 created "2016-06-24" @default.
- W2096669314 creator A5011194656 @default.
- W2096669314 creator A5024385877 @default.
- W2096669314 creator A5025415635 @default.
- W2096669314 creator A5035868784 @default.
- W2096669314 creator A5042875505 @default.
- W2096669314 creator A5050995269 @default.
- W2096669314 creator A5060181762 @default.
- W2096669314 creator A5072944678 @default.
- W2096669314 creator A5080750776 @default.
- W2096669314 creator A5088612128 @default.
- W2096669314 date "2013-11-21" @default.
- W2096669314 modified "2023-10-18" @default.
- W2096669314 title "Evaluation of the pharmacogenetics of immune recovery in treated HIV-infected patients" @default.
- W2096669314 cites W102025906 @default.
- W2096669314 cites W123422070 @default.
- W2096669314 cites W1508696496 @default.
- W2096669314 cites W1524350227 @default.
- W2096669314 cites W161836838 @default.
- W2096669314 cites W1739445979 @default.
- W2096669314 cites W1903734838 @default.
- W2096669314 cites W1963759891 @default.
- W2096669314 cites W1963963422 @default.
- W2096669314 cites W1968938233 @default.
- W2096669314 cites W1970278536 @default.
- W2096669314 cites W1972248422 @default.
- W2096669314 cites W1977586561 @default.
- W2096669314 cites W1981032737 @default.
- W2096669314 cites W1981067729 @default.
- W2096669314 cites W1981440980 @default.
- W2096669314 cites W1983720602 @default.
- W2096669314 cites W1987133643 @default.
- W2096669314 cites W1987625364 @default.
- W2096669314 cites W1991449638 @default.
- W2096669314 cites W1992539727 @default.
- W2096669314 cites W1993051112 @default.
- W2096669314 cites W1994078672 @default.
- W2096669314 cites W1995594396 @default.
- W2096669314 cites W1997351962 @default.
- W2096669314 cites W2003071165 @default.
- W2096669314 cites W2004258189 @default.
- W2096669314 cites W2005263803 @default.
- W2096669314 cites W2007021820 @default.
- W2096669314 cites W2008580763 @default.
- W2096669314 cites W2011030259 @default.
- W2096669314 cites W2012509863 @default.
- W2096669314 cites W2014536078 @default.
- W2096669314 cites W2014689400 @default.
- W2096669314 cites W2016558849 @default.
- W2096669314 cites W2017868468 @default.
- W2096669314 cites W2018555196 @default.
- W2096669314 cites W2018758739 @default.
- W2096669314 cites W2020213534 @default.
- W2096669314 cites W2022166810 @default.
- W2096669314 cites W2023061156 @default.
- W2096669314 cites W2026444780 @default.
- W2096669314 cites W2026616659 @default.
- W2096669314 cites W2026707655 @default.
- W2096669314 cites W2030393616 @default.
- W2096669314 cites W2032244821 @default.
- W2096669314 cites W2033848756 @default.
- W2096669314 cites W2033890031 @default.
- W2096669314 cites W2036898502 @default.
- W2096669314 cites W2042900104 @default.
- W2096669314 cites W2043643548 @default.
- W2096669314 cites W2046851673 @default.
- W2096669314 cites W2047925489 @default.
- W2096669314 cites W2050645428 @default.
- W2096669314 cites W2052615997 @default.
- W2096669314 cites W2055140814 @default.
- W2096669314 cites W2055807403 @default.
- W2096669314 cites W2060382789 @default.
- W2096669314 cites W2061631515 @default.
- W2096669314 cites W2062148688 @default.
- W2096669314 cites W2064597790 @default.
- W2096669314 cites W2071086973 @default.
- W2096669314 cites W2072047792 @default.
- W2096669314 cites W2074604380 @default.
- W2096669314 cites W2075906228 @default.
- W2096669314 cites W2077712940 @default.
- W2096669314 cites W2083430591 @default.
- W2096669314 cites W2090844420 @default.
- W2096669314 cites W2096715056 @default.
- W2096669314 cites W2098938825 @default.
- W2096669314 cites W2101135575 @default.
- W2096669314 cites W2105415723 @default.
- W2096669314 cites W2105517114 @default.
- W2096669314 cites W2106631668 @default.
- W2096669314 cites W2106781223 @default.
- W2096669314 cites W2110938611 @default.
- W2096669314 cites W2116067059 @default.
- W2096669314 cites W2116226103 @default.
- W2096669314 cites W2121098529 @default.
- W2096669314 cites W2121564154 @default.
- W2096669314 cites W2123078340 @default.
- W2096669314 cites W2124058652 @default.
- W2096669314 cites W2126427623 @default.