FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096669722> ?p ?o ?g. }

• W2096669722 endingPage "e1002746" @default.
• W2096669722 startingPage "e1002746" @default.
• W2096669722 abstract "Androgenetic alopecia (AGA) is a highly heritable condition and the most common form of hair loss in humans. Susceptibility loci have been described on the X chromosome and chromosome 20, but these loci explain a minority of its heritable variance. We conducted a large-scale meta-analysis of seven genome-wide association studies for early-onset AGA in 12,806 individuals of European ancestry. While replicating the two AGA loci on the X chromosome and chromosome 20, six novel susceptibility loci reached genome-wide significance (p = 2.62×10−9–1.01×10−12). Unexpectedly, we identified a risk allele at 17q21.31 that was recently associated with Parkinson's disease (PD) at a genome-wide significant level. We then tested the association between early-onset AGA and the risk of PD in a cross-sectional analysis of 568 PD cases and 7,664 controls. Early-onset AGA cases had significantly increased odds of subsequent PD (OR = 1.28, 95% confidence interval: 1.06–1.55, p = 8.9×10−3). Further, the AGA susceptibility alleles at the 17q21.31 locus are on the H1 haplotype, which is under negative selection in Europeans and has been linked to decreased fertility. Combining the risk alleles of six novel and two established susceptibility loci, we created a genotype risk score and tested its association with AGA in an additional sample. Individuals in the highest risk quartile of a genotype score had an approximately six-fold increased risk of early-onset AGA [odds ratio (OR) = 5.78, p = 1.4×10−88]. Our results highlight unexpected associations between early-onset AGA, Parkinson's disease, and decreased fertility, providing important insights into the pathophysiology of these conditions." @default.
• W2096669722 created "2016-06-24" @default.
• W2096669722 creator A5002110691 @default.
• W2096669722 creator A5002163035 @default.
• W2096669722 creator A5005555807 @default.
• W2096669722 creator A5007071328 @default.
• W2096669722 creator A5008405084 @default.
• W2096669722 creator A5009208804 @default.
• W2096669722 creator A5011269649 @default.
• W2096669722 creator A5011519020 @default.
• W2096669722 creator A5014617321 @default.
• W2096669722 creator A5015598407 @default.
• W2096669722 creator A5017466982 @default.
• W2096669722 creator A5018690824 @default.
• W2096669722 creator A5018835914 @default.
• W2096669722 creator A5022374956 @default.
• W2096669722 creator A5022547974 @default.
• W2096669722 creator A5022974046 @default.
• W2096669722 creator A5025062558 @default.
• W2096669722 creator A5027124617 @default.
• W2096669722 creator A5028661056 @default.
• W2096669722 creator A5028741548 @default.
• W2096669722 creator A5035461704 @default.
• W2096669722 creator A5039993328 @default.
• W2096669722 creator A5040364390 @default.
• W2096669722 creator A5042130650 @default.
• W2096669722 creator A5042348095 @default.
• W2096669722 creator A5042709773 @default.
• W2096669722 creator A5042877889 @default.
• W2096669722 creator A5045763456 @default.
• W2096669722 creator A5046821444 @default.
• W2096669722 creator A5056201449 @default.
• W2096669722 creator A5064749062 @default.
• W2096669722 creator A5065151039 @default.
• W2096669722 creator A5066194292 @default.
• W2096669722 creator A5067189241 @default.
• W2096669722 creator A5071616414 @default.
• W2096669722 creator A5079426765 @default.
• W2096669722 creator A5081675173 @default.
• W2096669722 creator A5082712082 @default.
• W2096669722 creator A5089298275 @default.
• W2096669722 date "2012-05-31" @default.
• W2096669722 modified "2023-10-16" @default.
• W2096669722 title "Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases" @default.
• W2096669722 cites W1963677817 @default.
• W2096669722 cites W1970560511 @default.
• W2096669722 cites W1971565607 @default.
• W2096669722 cites W1972039304 @default.
• W2096669722 cites W1973262157 @default.
• W2096669722 cites W1980610450 @default.
• W2096669722 cites W1983609593 @default.
• W2096669722 cites W1993438165 @default.
• W2096669722 cites W1994743649 @default.
• W2096669722 cites W2002212507 @default.
• W2096669722 cites W2007311033 @default.
• W2096669722 cites W2018907079 @default.
• W2096669722 cites W2020403018 @default.
• W2096669722 cites W2025253353 @default.
• W2096669722 cites W2030465046 @default.
• W2096669722 cites W2041922475 @default.
• W2096669722 cites W2045706913 @default.
• W2096669722 cites W2048883388 @default.
• W2096669722 cites W2049777896 @default.
• W2096669722 cites W2056731162 @default.
• W2096669722 cites W2058680827 @default.
• W2096669722 cites W2064293531 @default.
• W2096669722 cites W2065399757 @default.
• W2096669722 cites W2067745743 @default.
• W2096669722 cites W2076416177 @default.
• W2096669722 cites W2086792459 @default.
• W2096669722 cites W2089817267 @default.
• W2096669722 cites W2095304493 @default.
• W2096669722 cites W2095351291 @default.
• W2096669722 cites W2095821741 @default.
• W2096669722 cites W2097846180 @default.
• W2096669722 cites W2098187463 @default.
• W2096669722 cites W2100076759 @default.
• W2096669722 cites W2100941248 @default.
• W2096669722 cites W2106177570 @default.
• W2096669722 cites W2110863672 @default.
• W2096669722 cites W2112446953 @default.
• W2096669722 cites W2112765817 @default.
• W2096669722 cites W2113784410 @default.
• W2096669722 cites W2116626531 @default.
• W2096669722 cites W2119279196 @default.
• W2096669722 cites W2120644065 @default.
• W2096669722 cites W2132024988 @default.
• W2096669722 cites W2134170971 @default.
• W2096669722 cites W2134886133 @default.
• W2096669722 cites W2138069158 @default.
• W2096669722 cites W2140388664 @default.
• W2096669722 cites W2143591283 @default.
• W2096669722 cites W2144037754 @default.
• W2096669722 cites W2148641246 @default.
• W2096669722 cites W2148985730 @default.
• W2096669722 cites W2149791927 @default.
• W2096669722 cites W2151513507 @default.
• W2096669722 cites W2155214761 @default.

• next