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• W2096680073 abstract "The expression of type XV collagen was studied in cultured human dermal fibroblasts exposed to transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α) or interleukin-1β (IL-1β), cytokines which have been shown previously to alter the expression of several extracellular matrix genes. TGF-β enhanced the expression of the type XV collagen gene (COL15A1) in a time-dependent manner, up to 4.3-fold after 24 h of incubation, whereas TNF-α and IL-1β reduced the mRNA steady-state levels by 32 and 80%, respectively. When TGF-β and TNF-α were added together to the cultures, the stimulatory effect of TGF-β on type XV collagen gene expression was abrogated, indicating antagonistic modulation by these 2 cytokines. These data suggest that the cytokines tested in this study may contribute to the regulation of type XV collagen synthesis in a variety of tissues which have recently been shown to express this particular collagen gene." @default.
• W2096680073 created "2016-06-24" @default.
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• W2096680073 date "1999-10-01" @default.
• W2096680073 modified "2023-09-27" @default.
• W2096680073 title "Cytokine modulation of type XV collagen gene expression in human dermal fibroblast cultures" @default.
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• W2096680073 doi "https://doi.org/10.1111/j.1600-0625.1999.tb00390.x" @default.
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