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- W2096688730 abstract "Neuropsychiatric symptoms are common amongst Alzheimer's disease (AD) patients. Apart from cognitive decline, AD patients often present with depression and psychosis; however, the neurobiological processes underlying these associating conditions remain unclear. Chemical synaptic transmission is crucial in the communication between neurons, and ultimately brain function. We propose synaptic dysfunction as a possible underlying mechanism for AD and depression. Furthermore, since synaptic degeneration is likely to be a relatively early pathological event, we investigated the potential neuroprotective role of antidepressants. Primary hippocampal neurons treated with either oligomeric ß-amyloid (Aß) or corticoster one were used as an in vitro model for AD and depression, respectively. Immunocytochemical analyses of synaptic vesicle proteins were employed to investigate the pathological changes. Sub-lethal dosage of Aß (0.5μM) treatment for 24 hours resulted in reduction of pre-synaptic vesicle proteins synaptotagmin and synaptophysin. Pre-treatment for hour with antidepressants — either imipramine or escitalopram (10μM and 20μM for both) — were able to alleviate these pathological changes. Sub-lethal dosage of corticoster one (0.5μM) treatment for 24 hours resulted in aggregation of pre-synaptic vesicle proteins synaptotagmin and synaptophysin. Pre-treatments for hour with imipramine (10μM and 20μM) were able to alleviate these pathological changes. Pre-treatments for hour with escitalopram (10μM and 20μM) were only able to alleviate the aggregation of synaptotagmin, but not synaptophysin. These results show synaptic protein loss or aggregation in in vitro models of AD and depression. Antidepressants were able to alleviate some of the observed pathological changes. Further experiments will be conducted to explore the functional implications of these pathologies and the differential responses towards antidepressant treatments." @default.
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- W2096688730 date "2011-07-01" @default.
- W2096688730 modified "2023-10-02" @default.
- W2096688730 title "P3-222: Synaptic vesicle protein pathology in Alzheimer's disease and depression" @default.
- W2096688730 doi "https://doi.org/10.1016/j.jalz.2011.05.1664" @default.
- W2096688730 hasPublicationYear "2011" @default.
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