FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096705340> ?p ?o ?g. }

• W2096705340 endingPage "1055" @default.
• W2096705340 startingPage "1050" @default.
• W2096705340 abstract "Cytochrome P450 enzymes metabolize drugs and contribute to harmful drug-drug interactions. To decipher p450 activities, Veith et al. screen ∼17,000 compounds, including >1,000 FDA-approved drugs, against five important P450 isozymes and identify chemical structures that are enriched in compounds active against specific isozymes. The cytochrome P450 (CYP) gene family catalyzes drug metabolism and bioactivation and is therefore relevant to drug development. We determined potency values for 17,143 compounds against five recombinant CYP isozymes (1A2, 2C9, 2C19, 2D6 and 3A4) using an in vitro bioluminescent assay. The compounds included libraries of US Food and Drug Administration (FDA)-approved drugs and screening libraries. We observed cross-library isozyme inhibition (30–78%) with important differences between libraries. Whereas only 7% of the typical screening library was inactive against all five isozymes, 33% of FDA-approved drugs were inactive, reflecting the optimized pharmacological properties of the latter. Our results suggest that low CYP 2C isozyme activity is a common property of drugs, whereas other isozymes, such as CYP 2D6, show little discrimination between drugs and unoptimized compounds found in screening libraries. We also identified chemical substructures that differentiated between the five isozymes. The pharmacological compendium described here should further the understanding of CYP isozymes." @default.
• W2096705340 created "2016-06-24" @default.
• W2096705340 creator A5005522334 @default.
• W2096705340 creator A5005694515 @default.
• W2096705340 creator A5011366541 @default.
• W2096705340 creator A5036261777 @default.
• W2096705340 creator A5038384842 @default.
• W2096705340 creator A5044892430 @default.
• W2096705340 creator A5051543554 @default.
• W2096705340 creator A5066223674 @default.
• W2096705340 creator A5077773185 @default.
• W2096705340 creator A5081154325 @default.
• W2096705340 creator A5091208881 @default.
• W2096705340 date "2009-10-25" @default.
• W2096705340 modified "2023-10-16" @default.
• W2096705340 title "Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries" @default.
• W2096705340 cites W1508691659 @default.
• W2096705340 cites W1515773155 @default.
• W2096705340 cites W1518095282 @default.
• W2096705340 cites W1650427240 @default.
• W2096705340 cites W1746765074 @default.
• W2096705340 cites W1975147762 @default.
• W2096705340 cites W1977444218 @default.
• W2096705340 cites W1978639416 @default.
• W2096705340 cites W1991001144 @default.
• W2096705340 cites W1992475241 @default.
• W2096705340 cites W2006817285 @default.
• W2096705340 cites W2008470855 @default.
• W2096705340 cites W2009557438 @default.
• W2096705340 cites W2015215157 @default.
• W2096705340 cites W2016359652 @default.
• W2096705340 cites W2024059620 @default.
• W2096705340 cites W2024913341 @default.
• W2096705340 cites W2027376002 @default.
• W2096705340 cites W2038573181 @default.
• W2096705340 cites W2046079134 @default.
• W2096705340 cites W2062462877 @default.
• W2096705340 cites W2066541659 @default.
• W2096705340 cites W2069506489 @default.
• W2096705340 cites W2073417507 @default.
• W2096705340 cites W2078575919 @default.
• W2096705340 cites W2081659180 @default.
• W2096705340 cites W2085006365 @default.
• W2096705340 cites W2097100227 @default.
• W2096705340 cites W2098490713 @default.
• W2096705340 cites W2100117732 @default.
• W2096705340 cites W2101646342 @default.
• W2096705340 cites W2108056944 @default.
• W2096705340 cites W2111771265 @default.
• W2096705340 cites W2115763439 @default.
• W2096705340 cites W2118372925 @default.
• W2096705340 cites W2118405368 @default.
• W2096705340 cites W2127349017 @default.
• W2096705340 cites W2128056712 @default.
• W2096705340 cites W2128879247 @default.
• W2096705340 cites W2141115118 @default.
• W2096705340 cites W2154746639 @default.
• W2096705340 cites W2159266419 @default.
• W2096705340 cites W2170202887 @default.
• W2096705340 cites W2499289325 @default.
• W2096705340 cites W4230645052 @default.
• W2096705340 cites W4248144747 @default.
• W2096705340 doi "https://doi.org/10.1038/nbt.1581" @default.
• W2096705340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2783980" @default.
• W2096705340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19855396" @default.
• W2096705340 hasPublicationYear "2009" @default.
• W2096705340 type Work @default.
• W2096705340 sameAs 2096705340 @default.
• W2096705340 citedByCount "148" @default.
• W2096705340 countsByYear W20967053402012 @default.
• W2096705340 countsByYear W20967053402013 @default.
• W2096705340 countsByYear W20967053402014 @default.
• W2096705340 countsByYear W20967053402015 @default.
• W2096705340 countsByYear W20967053402016 @default.
• W2096705340 countsByYear W20967053402017 @default.
• W2096705340 countsByYear W20967053402018 @default.
• W2096705340 countsByYear W20967053402019 @default.
• W2096705340 countsByYear W20967053402020 @default.
• W2096705340 countsByYear W20967053402021 @default.
• W2096705340 countsByYear W20967053402022 @default.
• W2096705340 countsByYear W20967053402023 @default.
• W2096705340 crossrefType "journal-article" @default.
• W2096705340 hasAuthorship W2096705340A5005522334 @default.
• W2096705340 hasAuthorship W2096705340A5005694515 @default.
• W2096705340 hasAuthorship W2096705340A5011366541 @default.
• W2096705340 hasAuthorship W2096705340A5036261777 @default.
• W2096705340 hasAuthorship W2096705340A5038384842 @default.
• W2096705340 hasAuthorship W2096705340A5044892430 @default.
• W2096705340 hasAuthorship W2096705340A5051543554 @default.
• W2096705340 hasAuthorship W2096705340A5066223674 @default.
• W2096705340 hasAuthorship W2096705340A5077773185 @default.
• W2096705340 hasAuthorship W2096705340A5081154325 @default.
• W2096705340 hasAuthorship W2096705340A5091208881 @default.
• W2096705340 hasBestOaLocation W20967053402 @default.
• W2096705340 hasConcept C119795356 @default.
• W2096705340 hasConcept C181199279 @default.
• W2096705340 hasConcept C185592680 @default.
• W2096705340 hasConcept C2780035454 @default.

• next