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• W2096711580 abstract "Context: FSH is known to augment the production of essential germ cell (Gc) survival factors, lactate and estradiol, by Sertoli cells (Sc) of 18-d-old pubertal rats. However, the failure of gonadotropin and androgen treatment to initiate spermatogenesis in testis of some infertile men bearing Sc and Gc is intriguing. The role of FSH in regulation of lactate and estradiol production by primate Sc is currently unknown. Objective: The objective of the study was to determine the role of FSH in regulating lactate and estradiol production by primate Sc. Methods: Gc differentiation was initiated in male juvenile rhesus monkeys by pulsatile administration of GnRH for 4–5 wk. Sc from these pseudopubertal monkeys and pubertal rats were cultured. Production of lactate and estradiol in response to FSH and 8-bromoadenosine-cAMP was evaluated. Inhibin-βB expression, cAMP production, and cell proliferation were also assayed. Results: Unlike Sc from pubertal rats, Sc from pseudopubertal monkeys constitutively aromatized testosterone to estradiol and produced large amounts of lactate without FSH stimulation. Increasing doses of recombinant monkey FSH or 8-bromoadenosine-cAMP failed to augment lactate production, although they significantly augmented proliferation of Sc. Production of cAMP and expression of inhibin-βB mRNA were also remarkably augmented by recombinant monkey FSH. Conclusions: These results suggest that lactate and estradiol production by monkey Sc is not governed by FSH, as previously thought based on studies of rat Sc. Thus, in a clinical situation, assessment of such gonadotropin-independent functions of Sc may be obligatory for the diagnosis and management of certain forms of idiopathic male infertility." @default.
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• W2096711580 date "2006-03-01" @default.
• W2096711580 modified "2023-10-17" @default.
• W2096711580 title "Follicle-Stimulating Hormone-Independent Functions of Primate Sertoli Cells: Potential Implications in the Diagnosis and Management of Male Infertility" @default.
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• W2096711580 doi "https://doi.org/10.1210/jc.2005-2072" @default.
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