FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096718691> ?p ?o ?g. }

• W2096718691 endingPage "1156" @default.
• W2096718691 startingPage "1094" @default.
• W2096718691 abstract "SUMMARY The recent sequencing of the entire genomes of Mycoplasma genitalium and M. pneumoniae has attracted considerable attention to the molecular biology of mycoplasmas, the smallest self-replicating organisms. It appears that we are now much closer to the goal of defining, in molecular terms, the entire machinery of a self-replicating cell. Comparative genomics based on comparison of the genomic makeup of mycoplasmal genomes with those of other bacteria, has opened new ways of looking at the evolutionary history of the mycoplasmas. There is now solid genetic support for the hypothesis that mycoplasmas have evolved as a branch of gram-positive bacteria by a process of reductive evolution. During this process, the mycoplasmas lost considerable portions of their ancestors’ chromosomes but retained the genes essential for life. Thus, the mycoplasmal genomes carry a high percentage of conserved genes, greatly facilitating gene annotation. The significant genome compaction that occurred in mycoplasmas was made possible by adopting a parasitic mode of life. The supply of nutrients from their hosts apparently enabled mycoplasmas to lose, during evolution, the genes for many assimilative processes. During their evolution and adaptation to a parasitic mode of life, the mycoplasmas have developed various genetic systems providing a highly plastic set of variable surface proteins to evade the host immune system. The uniqueness of the mycoplasmal systems is manifested by the presence of highly mutable modules combined with an ability to expand the antigenic repertoire by generating structural alternatives, all compressed into limited genomic sequences. In the absence of a cell wall and a periplasmic space, the majority of surface variable antigens in mycoplasmas are lipoproteins. Apart from providing specific antimycoplasmal defense, the host immune system is also involved in the development of pathogenic lesions and exacerbation of mycoplasma induced diseases. Mycoplasmas are able to stimulate as well as suppress lymphocytes in a nonspecific, polyclonal manner, both in vitro and in vivo. As well as to affecting various subsets of lymphocytes, mycoplasmas and mycoplasma-derived cell components modulate the activities of monocytes/macrophages and NK cells and trigger the production of a wide variety of up-regulating and down-regulating cytokines and chemokines. Mycoplasma-mediated secretion of proinflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1 (IL-1), and IL-6, by macrophages and of up-regulating cytokines by mitogenically stimulated lymphocytes plays a major role in mycoplasma-induced immune system modulation and inflammatory responses." @default.
• W2096718691 created "2016-06-24" @default.
• W2096718691 creator A5024151177 @default.
• W2096718691 creator A5089184848 @default.
• W2096718691 creator A5089383287 @default.
• W2096718691 date "1998-12-01" @default.
• W2096718691 modified "2023-10-14" @default.
• W2096718691 title "Molecular Biology and Pathogenicity of Mycoplasmas" @default.
• W2096718691 cites W1235877488 @default.
• W2096718691 cites W1480565696 @default.
• W2096718691 cites W1484645455 @default.
• W2096718691 cites W1486293585 @default.
• W2096718691 cites W1489041710 @default.
• W2096718691 cites W1492111613 @default.
• W2096718691 cites W1498698257 @default.
• W2096718691 cites W1498829233 @default.
• W2096718691 cites W1500069580 @default.
• W2096718691 cites W1507647044 @default.
• W2096718691 cites W1511816638 @default.
• W2096718691 cites W1522152620 @default.
• W2096718691 cites W1528420424 @default.
• W2096718691 cites W1530426581 @default.
• W2096718691 cites W1533331354 @default.
• W2096718691 cites W1534992089 @default.
• W2096718691 cites W1537491192 @default.
• W2096718691 cites W1542085229 @default.
• W2096718691 cites W1549796636 @default.
• W2096718691 cites W1553338037 @default.
• W2096718691 cites W1553679364 @default.
• W2096718691 cites W1554395574 @default.
• W2096718691 cites W1555610195 @default.
• W2096718691 cites W1560626950 @default.
• W2096718691 cites W1562526277 @default.
• W2096718691 cites W1572330419 @default.
• W2096718691 cites W1572919668 @default.
• W2096718691 cites W1573080626 @default.
• W2096718691 cites W1576076165 @default.
• W2096718691 cites W1584657010 @default.
• W2096718691 cites W1588086311 @default.
• W2096718691 cites W1591079287 @default.
• W2096718691 cites W1591099433 @default.
• W2096718691 cites W1596499576 @default.
• W2096718691 cites W160534580 @default.
• W2096718691 cites W1606690173 @default.
• W2096718691 cites W1607869626 @default.
• W2096718691 cites W1614348091 @default.
• W2096718691 cites W1618885046 @default.
• W2096718691 cites W1620716033 @default.
• W2096718691 cites W1621620692 @default.
• W2096718691 cites W1637732739 @default.
• W2096718691 cites W1641704738 @default.
• W2096718691 cites W1649468963 @default.
• W2096718691 cites W1658410936 @default.
• W2096718691 cites W1662190871 @default.
• W2096718691 cites W1664224393 @default.
• W2096718691 cites W1677959031 @default.
• W2096718691 cites W1678993201 @default.
• W2096718691 cites W1679312428 @default.
• W2096718691 cites W171844193 @default.
• W2096718691 cites W1750447940 @default.
• W2096718691 cites W17527956 @default.
• W2096718691 cites W1765090546 @default.
• W2096718691 cites W176652973 @default.
• W2096718691 cites W1779083078 @default.
• W2096718691 cites W1793996699 @default.
• W2096718691 cites W1796095079 @default.
• W2096718691 cites W1820527381 @default.
• W2096718691 cites W1832831785 @default.
• W2096718691 cites W1837620133 @default.
• W2096718691 cites W1845647391 @default.
• W2096718691 cites W1855178100 @default.
• W2096718691 cites W1855641894 @default.
• W2096718691 cites W1856191772 @default.
• W2096718691 cites W1863090314 @default.
• W2096718691 cites W1867991215 @default.
• W2096718691 cites W1875767652 @default.
• W2096718691 cites W1878010313 @default.
• W2096718691 cites W1879332602 @default.
• W2096718691 cites W1879488282 @default.
• W2096718691 cites W1883603647 @default.
• W2096718691 cites W1888067462 @default.
• W2096718691 cites W1890649267 @default.
• W2096718691 cites W1894476426 @default.
• W2096718691 cites W1896376340 @default.
• W2096718691 cites W1896723554 @default.
• W2096718691 cites W1897935316 @default.
• W2096718691 cites W1901329768 @default.
• W2096718691 cites W1903475830 @default.
• W2096718691 cites W1903752741 @default.
• W2096718691 cites W191512943 @default.
• W2096718691 cites W1917713193 @default.
• W2096718691 cites W1917797231 @default.
• W2096718691 cites W1918267335 @default.
• W2096718691 cites W1921209694 @default.
• W2096718691 cites W1927565889 @default.
• W2096718691 cites W1933382017 @default.
• W2096718691 cites W1935212338 @default.
• W2096718691 cites W1939838429 @default.

• next