FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096724428> ?p ?o ?g. }

• W2096724428 endingPage "5930" @default.
• W2096724428 startingPage "5924" @default.
• W2096724428 abstract "We recently investigated the pharmacokinetics-pharmacodynamics (PK-PD) of tazobactam in combination with ceftolozane against an isogenic CTX-M-15-producing Escherichia coli triplet set, genetically engineered to transcribe different levels of blaCTX-M-15. The percentage of the dosing interval that tazobactam concentrations remained above a threshold (%Time>threshold) was identified as the PK-PD exposure measure that was most closely associated with efficacy. Moreover, the tazobactam concentration was dependent upon the enzyme transcription level. Given that the aforementioned strains were genetically engineered to transcribe a single β-lactamase enzyme and that clinical isolates typically produce multiple β-lactamase enzymes with various transcription levels, it is likely that the tazobactam threshold concentration is isolate/enzyme dependent. Our first objective was to characterize the relationship between the tazobactam %Time>threshold in combination with ceftolozane and efficacy using clinical isolates in an in vitro PK-PD infection model. Our second objective was to identify a translational relationship that would allow for the comodeling across clinical isolates. The initial challenge panel included four well-characterized β-lactamase-producing E. coli strains with variable enzyme expression and other resistance determinants. As evidenced by r(2) values of ranging from 0.90 to 0.99 for each clinical isolate, the observed data were well described by fitted functions describing the relationship between the tazobactam %Time>threshold and change in log10 CFU from baseline; however, the data from the four isolates did not comodel well. The threshold concentration identified for each isolate ranged from 0.5 to 4 mg/liter. We identified an enabling translational relationship for the tazobactam threshold that allowed comodeling of all four clinical isolates, which was the product of the individual isolate's ceftolozane-tazobactam MIC value and 0.5. As evidenced by an r(2) value of 0.90, the transformed data were well described by a fitted function describing the relationship between tazobactam %Time>threshold and change in log10 CFU from baseline. Due to these findings, the challenge panel was expanded to include three well-characterized β-lactamase-producing Klebsiella pneumoniae strains with variable enzyme expression and other resistance determinants. The translational relationship for the tazobactam threshold that allowed for the comodeling of the four E. coli isolates performed well for the expanded data set (seven isolates in total; four E. coli and three K. pneumoniae), as evidenced by an r(2) value of 0.84. This simple translational relationship is especially useful as it is directly linked to in vitro susceptibility test results, which are used to guide the clinician's choice of drug and dosing regimen." @default.
• W2096724428 created "2016-06-24" @default.
• W2096724428 creator A5019354236 @default.
• W2096724428 creator A5020171248 @default.
• W2096724428 creator A5026620873 @default.
• W2096724428 creator A5027004349 @default.
• W2096724428 creator A5040884440 @default.
• W2096724428 creator A5041157580 @default.
• W2096724428 creator A5052885935 @default.
• W2096724428 creator A5058850371 @default.
• W2096724428 creator A5073520723 @default.
• W2096724428 creator A5083112115 @default.
• W2096724428 creator A5084049528 @default.
• W2096724428 date "2013-12-01" @default.
• W2096724428 modified "2023-09-25" @default.
• W2096724428 title "Pharmacological Basis of β-Lactamase Inhibitor Therapeutics: Tazobactam in Combination with Ceftolozane" @default.
• W2096724428 cites W1978783455 @default.
• W2096724428 cites W1986441675 @default.
• W2096724428 cites W1997811421 @default.
• W2096724428 cites W2111292279 @default.
• W2096724428 cites W2134921838 @default.
• W2096724428 cites W2146291304 @default.
• W2096724428 cites W2171396020 @default.
• W2096724428 doi "https://doi.org/10.1128/aac.00656-13" @default.
• W2096724428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3837916" @default.
• W2096724428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24041895" @default.
• W2096724428 hasPublicationYear "2013" @default.
• W2096724428 type Work @default.
• W2096724428 sameAs 2096724428 @default.
• W2096724428 citedByCount "59" @default.
• W2096724428 countsByYear W20967244282014 @default.
• W2096724428 countsByYear W20967244282015 @default.
• W2096724428 countsByYear W20967244282016 @default.
• W2096724428 countsByYear W20967244282017 @default.
• W2096724428 countsByYear W20967244282018 @default.
• W2096724428 countsByYear W20967244282019 @default.
• W2096724428 countsByYear W20967244282020 @default.
• W2096724428 countsByYear W20967244282021 @default.
• W2096724428 countsByYear W20967244282022 @default.
• W2096724428 countsByYear W20967244282023 @default.
• W2096724428 crossrefType "journal-article" @default.
• W2096724428 hasAuthorship W2096724428A5019354236 @default.
• W2096724428 hasAuthorship W2096724428A5020171248 @default.
• W2096724428 hasAuthorship W2096724428A5026620873 @default.
• W2096724428 hasAuthorship W2096724428A5027004349 @default.
• W2096724428 hasAuthorship W2096724428A5040884440 @default.
• W2096724428 hasAuthorship W2096724428A5041157580 @default.
• W2096724428 hasAuthorship W2096724428A5052885935 @default.
• W2096724428 hasAuthorship W2096724428A5058850371 @default.
• W2096724428 hasAuthorship W2096724428A5073520723 @default.
• W2096724428 hasAuthorship W2096724428A5083112115 @default.
• W2096724428 hasAuthorship W2096724428A5084049528 @default.
• W2096724428 hasBestOaLocation W20967244281 @default.
• W2096724428 hasConcept C104317684 @default.
• W2096724428 hasConcept C111113717 @default.
• W2096724428 hasConcept C112705442 @default.
• W2096724428 hasConcept C181199279 @default.
• W2096724428 hasConcept C2778266534 @default.
• W2096724428 hasConcept C2779631663 @default.
• W2096724428 hasConcept C501593827 @default.
• W2096724428 hasConcept C547475151 @default.
• W2096724428 hasConcept C55493867 @default.
• W2096724428 hasConcept C86803240 @default.
• W2096724428 hasConcept C89423630 @default.
• W2096724428 hasConcept C94665300 @default.
• W2096724428 hasConcept C98274493 @default.
• W2096724428 hasConceptScore W2096724428C104317684 @default.
• W2096724428 hasConceptScore W2096724428C111113717 @default.
• W2096724428 hasConceptScore W2096724428C112705442 @default.
• W2096724428 hasConceptScore W2096724428C181199279 @default.
• W2096724428 hasConceptScore W2096724428C2778266534 @default.
• W2096724428 hasConceptScore W2096724428C2779631663 @default.
• W2096724428 hasConceptScore W2096724428C501593827 @default.
• W2096724428 hasConceptScore W2096724428C547475151 @default.
• W2096724428 hasConceptScore W2096724428C55493867 @default.
• W2096724428 hasConceptScore W2096724428C86803240 @default.
• W2096724428 hasConceptScore W2096724428C89423630 @default.
• W2096724428 hasConceptScore W2096724428C94665300 @default.
• W2096724428 hasConceptScore W2096724428C98274493 @default.
• W2096724428 hasIssue "12" @default.
• W2096724428 hasLocation W20967244281 @default.
• W2096724428 hasLocation W20967244282 @default.
• W2096724428 hasLocation W20967244283 @default.
• W2096724428 hasLocation W20967244284 @default.
• W2096724428 hasOpenAccess W2096724428 @default.
• W2096724428 hasPrimaryLocation W20967244281 @default.
• W2096724428 hasRelatedWork W1758514097 @default.
• W2096724428 hasRelatedWork W1997101420 @default.
• W2096724428 hasRelatedWork W2002058825 @default.
• W2096724428 hasRelatedWork W2010116591 @default.
• W2096724428 hasRelatedWork W2090099591 @default.
• W2096724428 hasRelatedWork W2108417615 @default.
• W2096724428 hasRelatedWork W2227061539 @default.
• W2096724428 hasRelatedWork W2410816841 @default.
• W2096724428 hasRelatedWork W2594910449 @default.
• W2096724428 hasRelatedWork W2992709639 @default.
• W2096724428 hasVolume "57" @default.
• W2096724428 isParatext "false" @default.

• next