FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096726229> ?p ?o ?g. }

• W2096726229 endingPage "1555" @default.
• W2096726229 startingPage "1546" @default.
• W2096726229 abstract "CRH, the principal regulator of the hypothalamic-pituitary-adrenal axis and modulator of autonomic nervous system activity, also participates in the regulation of appetite and energy expenditure. Antalarmin, a pyrrolopyrimidine compound, antagonizes CRH type 1 receptor-mediated effects of CRH, including pituitary ACTH release, stress behaviors, and acute inflammation. We administered antalarmin chronically to evaluate its effects on hypothalamic-pituitary-adrenal axis function and metabolic status. Adult male rats were treated twice daily with 20 mg/kg of ip antalarmin or placebo over 11 days. The animals were weighed; plasma ACTH, corticosterone, leptin, and blood glucose levels were determined; and morphometric analyses were performed to determine adrenal size and structure, including sizing, histochemistry, immunohistochemistry, and electron microscopy. Leptin messenger RNA expression in peripheral fat was analyzed by Northern blot. Antalarmin decreased plasma ACTH (mean ± sd, 2.62 ± 0.063 pg/ml) and corticosterone concentrations (10.21 ± 1.80 μg/dl) compared with those in vehicle-treated rats [respectively, 5.3 ± 2.0 (P < 0.05) and 57.02 ± 8.86 (P < 0.01)]. Antalarmin had no significant effect on body weight, plasma leptin, or blood glucose concentrations or fat cell leptin messenger RNA levels. The width of the adrenal cortex of animals treated with antalarmin was reduced by 31% compared with that in controls without atrophy of the gland. On the ultrastructural level, adrenocortical cells were in a hypofunctional state characterized by reduced vascularization, increased content of lipid droplets, and tubulovesicular mitochondria with fewer inner membranes. The apoptotic rate was increased in the outer zona fasciculata of animals treated with the antagonist (26.6 ± 3.58%) compared with that in placebo-treated controls (6.8 ± 0.91%). We conclude that chronic administration of antalarmin does not affect body weight, carbohydrate metabolism, or leptin expression, whereas it reduces adrenocortical function mildly, without anatomical, clinical, or biochemical evidence of causing adrenal atrophy. These results are promising for future uses of such an antagonist in the clinic." @default.
• W2096726229 created "2016-06-24" @default.
• W2096726229 creator A5001688219 @default.
• W2096726229 creator A5002810674 @default.
• W2096726229 creator A5005518628 @default.
• W2096726229 creator A5006906048 @default.
• W2096726229 creator A5024911159 @default.
• W2096726229 creator A5031397502 @default.
• W2096726229 creator A5046164327 @default.
• W2096726229 creator A5054430945 @default.
• W2096726229 creator A5070892766 @default.
• W2096726229 creator A5072565784 @default.
• W2096726229 creator A5088106835 @default.
• W2096726229 date "1998-04-01" @default.
• W2096726229 modified "2023-09-26" @default.
• W2096726229 title "Chronic Effects of a Nonpeptide Corticotropin-Releasing Hormone Type I Receptor Antagonist on Pituitary-Adrenal Function, Body Weight, and Metabolic Regulation¹" @default.
• W2096726229 cites W1524880303 @default.
• W2096726229 cites W1883066942 @default.
• W2096726229 cites W1964889875 @default.
• W2096726229 cites W1971922927 @default.
• W2096726229 cites W1974924659 @default.
• W2096726229 cites W1984277590 @default.
• W2096726229 cites W1992866860 @default.
• W2096726229 cites W1993073314 @default.
• W2096726229 cites W1994854277 @default.
• W2096726229 cites W1996713062 @default.
• W2096726229 cites W2001547694 @default.
• W2096726229 cites W2007482590 @default.
• W2096726229 cites W2007636157 @default.
• W2096726229 cites W2008074001 @default.
• W2096726229 cites W2009968514 @default.
• W2096726229 cites W2012418304 @default.
• W2096726229 cites W2015630835 @default.
• W2096726229 cites W2026425480 @default.
• W2096726229 cites W2028632688 @default.
• W2096726229 cites W2038500073 @default.
• W2096726229 cites W2042857419 @default.
• W2096726229 cites W2043273622 @default.
• W2096726229 cites W2045274470 @default.
• W2096726229 cites W2046934118 @default.
• W2096726229 cites W2047620892 @default.
• W2096726229 cites W2049661605 @default.
• W2096726229 cites W2051217992 @default.
• W2096726229 cites W2051818439 @default.
• W2096726229 cites W2052582710 @default.
• W2096726229 cites W2052853635 @default.
• W2096726229 cites W2053785195 @default.
• W2096726229 cites W2056432051 @default.
• W2096726229 cites W2065389660 @default.
• W2096726229 cites W2065864773 @default.
• W2096726229 cites W2066990412 @default.
• W2096726229 cites W2071896431 @default.
• W2096726229 cites W2077549016 @default.
• W2096726229 cites W2079718339 @default.
• W2096726229 cites W2082146795 @default.
• W2096726229 cites W2091087465 @default.
• W2096726229 cites W2093010348 @default.
• W2096726229 cites W2093371722 @default.
• W2096726229 cites W2094989225 @default.
• W2096726229 cites W2098627686 @default.
• W2096726229 cites W2099485290 @default.
• W2096726229 cites W2102618758 @default.
• W2096726229 cites W2111232488 @default.
• W2096726229 cites W2160635355 @default.
• W2096726229 cites W2161187682 @default.
• W2096726229 cites W2165976043 @default.
• W2096726229 cites W2171846995 @default.
• W2096726229 cites W2267586012 @default.
• W2096726229 cites W2300209542 @default.
• W2096726229 cites W2313664830 @default.
• W2096726229 cites W2341830035 @default.
• W2096726229 cites W3012472868 @default.
• W2096726229 cites W61520244 @default.
• W2096726229 cites W2081264545 @default.
• W2096726229 doi "https://doi.org/10.1210/endo.139.4.5938" @default.
• W2096726229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9528933" @default.
• W2096726229 hasPublicationYear "1998" @default.
• W2096726229 type Work @default.
• W2096726229 sameAs 2096726229 @default.
• W2096726229 citedByCount "75" @default.
• W2096726229 countsByYear W20967262292013 @default.
• W2096726229 countsByYear W20967262292015 @default.
• W2096726229 countsByYear W20967262292016 @default.
• W2096726229 countsByYear W20967262292018 @default.
• W2096726229 countsByYear W20967262292019 @default.
• W2096726229 countsByYear W20967262292020 @default.
• W2096726229 countsByYear W20967262292022 @default.
• W2096726229 countsByYear W20967262292023 @default.
• W2096726229 crossrefType "journal-article" @default.
• W2096726229 hasAuthorship W2096726229A5001688219 @default.
• W2096726229 hasAuthorship W2096726229A5002810674 @default.
• W2096726229 hasAuthorship W2096726229A5005518628 @default.
• W2096726229 hasAuthorship W2096726229A5006906048 @default.
• W2096726229 hasAuthorship W2096726229A5024911159 @default.
• W2096726229 hasAuthorship W2096726229A5031397502 @default.
• W2096726229 hasAuthorship W2096726229A5046164327 @default.
• W2096726229 hasAuthorship W2096726229A5054430945 @default.
• W2096726229 hasAuthorship W2096726229A5070892766 @default.

• next