FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096733783> ?p ?o ?g. }

• W2096733783 endingPage "e99350" @default.
• W2096733783 startingPage "e99350" @default.
• W2096733783 abstract "Despite circumstantial evidence postulating a protective role for NK cells in many fibrotic conditions, their contribution to the development of pulmonary fibrosis has yet to be tested. Lung-migrating NK cells are thought to attenuate the development of bleomycin induced pulmonary fibrosis (BIPF) by providing anti-fibrotic mediators and cytokines, such as IFN-γ. If true, we reasoned that depletion of NK cells during experimentally-induced fibrotic disease would lead to exacerbated fibrosis. To test this, we treated mice with NK cell-depleting antisera (anti-asialo GM1) and evaluated lung inflammation and fibrosis in the BIPF model. While NK cell infiltration into the airways was maximal at day 10 after bleomycin injection, NK cells represented a minor portion (1–3%) of the total leukocytes in BAL fluid. Anti-asialo GM1 significantly abrogated NK cell numbers over the course of the disease. Depletion of NK cells with anti-asialo GM1 before and throughout the BIPF model, or during just the fibrotic phase did not alter fibrosis development or affect the levels of any of the pro-inflammatory/pro-fibrotic cytokines measured (IL-1β, IL-17, IFN-γ, TGF-β and TNF-α). In addition, adoptively transferred NK cells, which were detectable systemically and in the airways throughout BIPF, failed to impact lung fibrosis. These findings indicate that NK cells likely do not play an essential protective role in controlling pulmonary fibrosis development." @default.
• W2096733783 created "2016-06-24" @default.
• W2096733783 creator A5022371505 @default.
• W2096733783 creator A5036103628 @default.
• W2096733783 date "2014-06-12" @default.
• W2096733783 modified "2023-10-09" @default.
• W2096733783 title "Anti-Asialo GM1 NK Cell Depleting Antibody Does Not Alter the Development of Bleomycin Induced Pulmonary Fibrosis" @default.
• W2096733783 cites W1964296299 @default.
• W2096733783 cites W1967108732 @default.
• W2096733783 cites W1968460020 @default.
• W2096733783 cites W1970419044 @default.
• W2096733783 cites W1994378435 @default.
• W2096733783 cites W2001280594 @default.
• W2096733783 cites W2017354770 @default.
• W2096733783 cites W2018809578 @default.
• W2096733783 cites W2031598839 @default.
• W2096733783 cites W2049236281 @default.
• W2096733783 cites W2053754111 @default.
• W2096733783 cites W2055348484 @default.
• W2096733783 cites W2056566791 @default.
• W2096733783 cites W2068055816 @default.
• W2096733783 cites W2075400164 @default.
• W2096733783 cites W2075578688 @default.
• W2096733783 cites W2085662246 @default.
• W2096733783 cites W2090897026 @default.
• W2096733783 cites W2091572768 @default.
• W2096733783 cites W2095715691 @default.
• W2096733783 cites W2098765934 @default.
• W2096733783 cites W2101749956 @default.
• W2096733783 cites W2103225233 @default.
• W2096733783 cites W2118637098 @default.
• W2096733783 cites W2119788880 @default.
• W2096733783 cites W2120446140 @default.
• W2096733783 cites W2122758441 @default.
• W2096733783 cites W2131029325 @default.
• W2096733783 cites W2132084960 @default.
• W2096733783 cites W2139694053 @default.
• W2096733783 cites W2150678429 @default.
• W2096733783 cites W2159679191 @default.
• W2096733783 cites W2162809912 @default.
• W2096733783 cites W2164359892 @default.
• W2096733783 cites W2167211373 @default.
• W2096733783 cites W2169692356 @default.
• W2096733783 cites W2184117640 @default.
• W2096733783 cites W2187465260 @default.
• W2096733783 cites W2338532680 @default.
• W2096733783 cites W2626588662 @default.
• W2096733783 doi "https://doi.org/10.1371/journal.pone.0099350" @default.
• W2096733783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4055641" @default.
• W2096733783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24922516" @default.
• W2096733783 hasPublicationYear "2014" @default.
• W2096733783 type Work @default.
• W2096733783 sameAs 2096733783 @default.
• W2096733783 citedByCount "18" @default.
• W2096733783 countsByYear W20967337832015 @default.
• W2096733783 countsByYear W20967337832016 @default.
• W2096733783 countsByYear W20967337832017 @default.
• W2096733783 countsByYear W20967337832018 @default.
• W2096733783 countsByYear W20967337832019 @default.
• W2096733783 countsByYear W20967337832020 @default.
• W2096733783 countsByYear W20967337832021 @default.
• W2096733783 countsByYear W20967337832023 @default.
• W2096733783 crossrefType "journal-article" @default.
• W2096733783 hasAuthorship W2096733783A5022371505 @default.
• W2096733783 hasAuthorship W2096733783A5036103628 @default.
• W2096733783 hasBestOaLocation W20967337831 @default.
• W2096733783 hasConcept C126322002 @default.
• W2096733783 hasConcept C142724271 @default.
• W2096733783 hasConcept C203014093 @default.
• W2096733783 hasConcept C2776232574 @default.
• W2096733783 hasConcept C2776694085 @default.
• W2096733783 hasConcept C2776914184 @default.
• W2096733783 hasConcept C2777714996 @default.
• W2096733783 hasConcept C2780559512 @default.
• W2096733783 hasConcept C2781244666 @default.
• W2096733783 hasConcept C71924100 @default.
• W2096733783 hasConceptScore W2096733783C126322002 @default.
• W2096733783 hasConceptScore W2096733783C142724271 @default.
• W2096733783 hasConceptScore W2096733783C203014093 @default.
• W2096733783 hasConceptScore W2096733783C2776232574 @default.
• W2096733783 hasConceptScore W2096733783C2776694085 @default.
• W2096733783 hasConceptScore W2096733783C2776914184 @default.
• W2096733783 hasConceptScore W2096733783C2777714996 @default.
• W2096733783 hasConceptScore W2096733783C2780559512 @default.
• W2096733783 hasConceptScore W2096733783C2781244666 @default.
• W2096733783 hasConceptScore W2096733783C71924100 @default.
• W2096733783 hasIssue "6" @default.
• W2096733783 hasLocation W20967337831 @default.
• W2096733783 hasLocation W20967337832 @default.
• W2096733783 hasLocation W20967337833 @default.
• W2096733783 hasLocation W20967337834 @default.
• W2096733783 hasLocation W20967337835 @default.
• W2096733783 hasOpenAccess W2096733783 @default.
• W2096733783 hasPrimaryLocation W20967337831 @default.
• W2096733783 hasRelatedWork W2102239057 @default.
• W2096733783 hasRelatedWork W2121729413 @default.
• W2096733783 hasRelatedWork W2359640985 @default.
• W2096733783 hasRelatedWork W2364204753 @default.

• next