FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096751201> ?p ?o ?g. }

• W2096751201 endingPage "2893" @default.
• W2096751201 startingPage "2883" @default.
• W2096751201 abstract "Abstract Human Immune System (HIS) mice represent a novel biotechnology platform to dissect human haematopoiesis and immune responses. However, the limited human T‐cell development that is observed in HIS mice restricts its utility for these applications. Here, we address whether reduced thymopoiesis in HIS mice reflects an autonomous defect in T‐cell precursors and/or a defect in the murine thymic niche. Human thymocyte precursors seed the mouse thymus and their reciprocal interactions with murine thymic epithelial cells (TECs) led to both T‐cell and TEC maturation. The human thymocyte subsets observed in HIS mice demonstrated survival, proliferative and phenotypic characteristics of their normal human counterparts, suggesting that the intrinsic developmental program of human thymocytes unfolds normally in this xenograft setting. We observed that exogenous administration of human IL‐15/IL‐15Rα agonistic complexes induced the survival, proliferation and absolute numbers of immature human thymocyte subsets, without any obvious effect on cell‐surface phenotype or TCR Vβ usage amongst the newly selected mature single‐positive (SP) thymocytes. Finally, when IL‐15 was administered early after stem cell transplantation, we noted accelerated thymopoiesis resulting in the more rapid appearance of peripheral naïve T cells. Our results highlight the functional capacity of murine thymic stroma cells in promoting human thymopoiesis in HIS mice but suggest that the “cross‐talk” between murine thymic stroma and human haematopoietic precursors may be suboptimal. As IL‐15 immunotherapy promotes early thymopoiesis, this novel approach could be used to reduce the period of T‐cell immunodeficiency in the post‐transplant clinical setting." @default.
• W2096751201 created "2016-06-24" @default.
• W2096751201 creator A5013085782 @default.
• W2096751201 creator A5021252237 @default.
• W2096751201 creator A5028469752 @default.
• W2096751201 creator A5032817893 @default.
• W2096751201 creator A5053767878 @default.
• W2096751201 creator A5070460836 @default.
• W2096751201 creator A5082369585 @default.
• W2096751201 creator A5083003001 @default.
• W2096751201 creator A5087932335 @default.
• W2096751201 creator A5089955013 @default.
• W2096751201 date "2011-08-30" @default.
• W2096751201 modified "2023-10-18" @default.
• W2096751201 title "Autonomous and extrinsic regulation of thymopoiesis inhuman immune system (HIS) mice" @default.
• W2096751201 cites W1503131941 @default.
• W2096751201 cites W1536420296 @default.
• W2096751201 cites W1555988808 @default.
• W2096751201 cites W1598239336 @default.
• W2096751201 cites W1913179054 @default.
• W2096751201 cites W1964077677 @default.
• W2096751201 cites W1972044265 @default.
• W2096751201 cites W1980005768 @default.
• W2096751201 cites W1983336399 @default.
• W2096751201 cites W1988181926 @default.
• W2096751201 cites W2000757975 @default.
• W2096751201 cites W2005942970 @default.
• W2096751201 cites W2028091596 @default.
• W2096751201 cites W2028261045 @default.
• W2096751201 cites W2032406291 @default.
• W2096751201 cites W2049195346 @default.
• W2096751201 cites W2057698592 @default.
• W2096751201 cites W2067194336 @default.
• W2096751201 cites W2073489229 @default.
• W2096751201 cites W2074321172 @default.
• W2096751201 cites W2076817531 @default.
• W2096751201 cites W2082631225 @default.
• W2096751201 cites W2086121828 @default.
• W2096751201 cites W2090489211 @default.
• W2096751201 cites W2090644618 @default.
• W2096751201 cites W2096992142 @default.
• W2096751201 cites W2098286616 @default.
• W2096751201 cites W2098404904 @default.
• W2096751201 cites W2108183870 @default.
• W2096751201 cites W2108454894 @default.
• W2096751201 cites W2109388378 @default.
• W2096751201 cites W2114530568 @default.
• W2096751201 cites W2121841446 @default.
• W2096751201 cites W2134705919 @default.
• W2096751201 cites W2136920402 @default.
• W2096751201 cites W2142285575 @default.
• W2096751201 cites W2142937426 @default.
• W2096751201 cites W2143685430 @default.
• W2096751201 cites W2147546467 @default.
• W2096751201 cites W2154670632 @default.
• W2096751201 cites W2156230193 @default.
• W2096751201 cites W2156955142 @default.
• W2096751201 cites W2168920723 @default.
• W2096751201 cites W2186507474 @default.
• W2096751201 cites W28492832 @default.
• W2096751201 cites W4313342355 @default.
• W2096751201 doi "https://doi.org/10.1002/eji.201141586" @default.
• W2096751201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21739431" @default.
• W2096751201 hasPublicationYear "2011" @default.
• W2096751201 type Work @default.
• W2096751201 sameAs 2096751201 @default.
• W2096751201 citedByCount "18" @default.
• W2096751201 countsByYear W20967512012012 @default.
• W2096751201 countsByYear W20967512012013 @default.
• W2096751201 countsByYear W20967512012014 @default.
• W2096751201 countsByYear W20967512012015 @default.
• W2096751201 countsByYear W20967512012016 @default.
• W2096751201 countsByYear W20967512012018 @default.
• W2096751201 countsByYear W20967512012019 @default.
• W2096751201 countsByYear W20967512012020 @default.
• W2096751201 countsByYear W20967512012023 @default.
• W2096751201 crossrefType "journal-article" @default.
• W2096751201 hasAuthorship W2096751201A5013085782 @default.
• W2096751201 hasAuthorship W2096751201A5021252237 @default.
• W2096751201 hasAuthorship W2096751201A5028469752 @default.
• W2096751201 hasAuthorship W2096751201A5032817893 @default.
• W2096751201 hasAuthorship W2096751201A5053767878 @default.
• W2096751201 hasAuthorship W2096751201A5070460836 @default.
• W2096751201 hasAuthorship W2096751201A5082369585 @default.
• W2096751201 hasAuthorship W2096751201A5083003001 @default.
• W2096751201 hasAuthorship W2096751201A5087932335 @default.
• W2096751201 hasAuthorship W2096751201A5089955013 @default.
• W2096751201 hasConcept C104317684 @default.
• W2096751201 hasConcept C109159458 @default.
• W2096751201 hasConcept C126322002 @default.
• W2096751201 hasConcept C127716648 @default.
• W2096751201 hasConcept C203014093 @default.
• W2096751201 hasConcept C2776090121 @default.
• W2096751201 hasConcept C2778954852 @default.
• W2096751201 hasConcept C28328180 @default.
• W2096751201 hasConcept C2911091166 @default.
• W2096751201 hasConcept C502942594 @default.
• W2096751201 hasConcept C54355233 @default.

• next