FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096753485> ?p ?o ?g. }

• W2096753485 endingPage "289" @default.
• W2096753485 startingPage "283" @default.
• W2096753485 abstract "Pregnancy-associated malaria caused by Plasmodium falciparum adherence to chondroitin sulfate A in the placental intervillous space is a major cause of low birthweight and maternal anaemia in areas of endemic P falciparum transmission. Adhesion-blocking antibodies that specifically recognise parasite-encoded variant surface antigens (VSA) are associated with resistance to pregnancy-associated malaria. We looked for a possible relation between VSA-specific antibody concentrations, placental infection, and protection from low birthweight and maternal anaemia.We used flow cytometry to measure VSA-specific IgG concentrations in plasma samples taken during child birth from 477 Kenyan women selected from a cohort of 910 women on the basis of HIV-1 status, gravidity, and placental histology. We measured VSA expressed by one placental P falciparum isolate and two isolates selected or not selected for chondroitin sulfate A adhesiveness in-vitro.Concentrations of plasma IgG specific for VSA, expressed by chondroitin sulfate A-adhering parasites (VSA in pregnancy-associated malaria or vsa-pam), increased with gravidity and were associated with placental histological findings. Women with chronic pregnancy-associated malaria and low or absent VSA-PAM-specific IgG had lower haemoglobin values (reduced by 17 g/L; 95% CI 8.1-25.2) and delivered smaller babies (birthweight reduced by 0.26 kg; 0.10-0.55) than did corresponding women with high VSA-PAM-specific IgG. No such relation was shown for concentrations of IgG with specificity for non-pregnancy-associated malaria VSA.VSA-PAM-specific IgG protects against low birthweight and maternal anaemia. Our data indicate an important mechanism of clinical protection against malaria and raise hope for the clinical effectiveness of a potential VSA-based vaccine against pregnancy-associated malaria." @default.
• W2096753485 created "2016-06-24" @default.
• W2096753485 creator A5009937760 @default.
• W2096753485 creator A5032268497 @default.
• W2096753485 creator A5036212647 @default.
• W2096753485 creator A5053481612 @default.
• W2096753485 creator A5058998346 @default.
• W2096753485 creator A5072332085 @default.
• W2096753485 date "2004-01-01" @default.
• W2096753485 modified "2023-10-11" @default.
• W2096753485 title "Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria" @default.
• W2096753485 cites W1546555723 @default.
• W2096753485 cites W1829384068 @default.
• W2096753485 cites W1935807092 @default.
• W2096753485 cites W1975060205 @default.
• W2096753485 cites W1983320016 @default.
• W2096753485 cites W2010795697 @default.
• W2096753485 cites W2011606993 @default.
• W2096753485 cites W2019851585 @default.
• W2096753485 cites W2028719460 @default.
• W2096753485 cites W2039900986 @default.
• W2096753485 cites W2041667769 @default.
• W2096753485 cites W2045959919 @default.
• W2096753485 cites W2076000327 @default.
• W2096753485 cites W2093451052 @default.
• W2096753485 cites W2099226620 @default.
• W2096753485 cites W2106776894 @default.
• W2096753485 cites W2107182419 @default.
• W2096753485 cites W2107646820 @default.
• W2096753485 cites W2108482246 @default.
• W2096753485 cites W2112373545 @default.
• W2096753485 cites W2112884272 @default.
• W2096753485 cites W2129781353 @default.
• W2096753485 cites W2132618017 @default.
• W2096753485 cites W2134191208 @default.
• W2096753485 cites W2146484864 @default.
• W2096753485 cites W2156236618 @default.
• W2096753485 cites W2409643785 @default.
• W2096753485 doi "https://doi.org/10.1016/s0140-6736(03)15386-x" @default.
• W2096753485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14751701" @default.
• W2096753485 hasPublicationYear "2004" @default.
• W2096753485 type Work @default.
• W2096753485 sameAs 2096753485 @default.
• W2096753485 citedByCount "265" @default.
• W2096753485 countsByYear W20967534852012 @default.
• W2096753485 countsByYear W20967534852013 @default.
• W2096753485 countsByYear W20967534852014 @default.
• W2096753485 countsByYear W20967534852015 @default.
• W2096753485 countsByYear W20967534852016 @default.
• W2096753485 countsByYear W20967534852017 @default.
• W2096753485 countsByYear W20967534852018 @default.
• W2096753485 countsByYear W20967534852019 @default.
• W2096753485 countsByYear W20967534852020 @default.
• W2096753485 countsByYear W20967534852021 @default.
• W2096753485 countsByYear W20967534852022 @default.
• W2096753485 countsByYear W20967534852023 @default.
• W2096753485 crossrefType "journal-article" @default.
• W2096753485 hasAuthorship W2096753485A5009937760 @default.
• W2096753485 hasAuthorship W2096753485A5032268497 @default.
• W2096753485 hasAuthorship W2096753485A5036212647 @default.
• W2096753485 hasAuthorship W2096753485A5053481612 @default.
• W2096753485 hasAuthorship W2096753485A5058998346 @default.
• W2096753485 hasAuthorship W2096753485A5072332085 @default.
• W2096753485 hasConcept C147483822 @default.
• W2096753485 hasConcept C159654299 @default.
• W2096753485 hasConcept C16685009 @default.
• W2096753485 hasConcept C172680121 @default.
• W2096753485 hasConcept C203014093 @default.
• W2096753485 hasConcept C2776953305 @default.
• W2096753485 hasConcept C2778048844 @default.
• W2096753485 hasConcept C2778371730 @default.
• W2096753485 hasConcept C2779234561 @default.
• W2096753485 hasConcept C42407357 @default.
• W2096753485 hasConcept C54355233 @default.
• W2096753485 hasConcept C71924100 @default.
• W2096753485 hasConcept C79919700 @default.
• W2096753485 hasConcept C86803240 @default.
• W2096753485 hasConceptScore W2096753485C147483822 @default.
• W2096753485 hasConceptScore W2096753485C159654299 @default.
• W2096753485 hasConceptScore W2096753485C16685009 @default.
• W2096753485 hasConceptScore W2096753485C172680121 @default.
• W2096753485 hasConceptScore W2096753485C203014093 @default.
• W2096753485 hasConceptScore W2096753485C2776953305 @default.
• W2096753485 hasConceptScore W2096753485C2778048844 @default.
• W2096753485 hasConceptScore W2096753485C2778371730 @default.
• W2096753485 hasConceptScore W2096753485C2779234561 @default.
• W2096753485 hasConceptScore W2096753485C42407357 @default.
• W2096753485 hasConceptScore W2096753485C54355233 @default.
• W2096753485 hasConceptScore W2096753485C71924100 @default.
• W2096753485 hasConceptScore W2096753485C79919700 @default.
• W2096753485 hasConceptScore W2096753485C86803240 @default.
• W2096753485 hasIssue "9405" @default.
• W2096753485 hasLocation W20967534851 @default.
• W2096753485 hasLocation W20967534852 @default.
• W2096753485 hasOpenAccess W2096753485 @default.
• W2096753485 hasPrimaryLocation W20967534851 @default.
• W2096753485 hasRelatedWork W2014192789 @default.
• W2096753485 hasRelatedWork W2021845296 @default.

• next