FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096756834> ?p ?o ?g. }

• W2096756834 endingPage "260" @default.
• W2096756834 startingPage "251" @default.
• W2096756834 abstract "RPTP mu is a transmembrane protein tyrosine phosphatase with an adhesion molecule-like ectodomain. It has recently been shown that RPTP mu mediates homophilic interactions when expressed in insect cells. In this study, we have examined how RPTP mu may function as a cell contact receptor in mink lung epithelial cells, which express RPTPmu endogenously, as well as in transfected 3T3 cells. We find that RPTP mu has a relatively short half-life (3-4 hours) and undergoes posttranslational cleavage into two noncovalently associated subunits, with both cleaved and uncleaved molecules being present on the cell surface (roughly at a 1:1 ratio); shedding of the ectodomain subunit is observed in exponentially growing cells. Immunofluorescence analysis reveals that surface expression of RPTPmu is restricted to regions of tight cell-cell contact. RPTPmu surface expression increases significantly with increasing cell density. This density-induced upregulation of RPTP mu is independent of its catalytic activity and is also observed when transcription is driven by a constitutive promoter, indicating that modulation of RPTPmu surface expression occurs posttranscriptionally. Based on our results, we propose the following model of RPTP mu function: In the absence of cell-cell contact, newly synthesized RPTP mu molecules are rapidly cleared from the cell surface. Cell-cell contact causes RPTPmu to be trapped at the surface through homophilic binding, resulting in accumulation of RPTP mu at intercellular contact regions. This contact-induced clustering of RPTPmu may then lead to tyrosine dephosphorylation of intracellular substrates at cell-cell contacts." @default.
• W2096756834 created "2016-06-24" @default.
• W2096756834 creator A5007446364 @default.
• W2096756834 creator A5037381969 @default.
• W2096756834 creator A5045676857 @default.
• W2096756834 creator A5061490638 @default.
• W2096756834 creator A5071741692 @default.
• W2096756834 creator A5091856094 @default.
• W2096756834 date "1995-10-01" @default.
• W2096756834 modified "2023-09-30" @default.
• W2096756834 title "Cell surface expression of receptor protein tyrosine phosphatase RPTP mu is regulated by cell-cell contact." @default.
• W2096756834 cites W1504159440 @default.
• W2096756834 cites W1578737646 @default.
• W2096756834 cites W1674557579 @default.
• W2096756834 cites W1853885983 @default.
• W2096756834 cites W1968610357 @default.
• W2096756834 cites W1976058749 @default.
• W2096756834 cites W1976634502 @default.
• W2096756834 cites W1997304990 @default.
• W2096756834 cites W2016571619 @default.
• W2096756834 cites W2059452371 @default.
• W2096756834 cites W2068446924 @default.
• W2096756834 cites W2085634797 @default.
• W2096756834 cites W2136755380 @default.
• W2096756834 cites W2160421139 @default.
• W2096756834 cites W2161454032 @default.
• W2096756834 cites W2183795009 @default.
• W2096756834 cites W2414903038 @default.
• W2096756834 cites W246090348 @default.
• W2096756834 cites W2506293158 @default.
• W2096756834 doi "https://doi.org/10.1083/jcb.131.1.251" @default.
• W2096756834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2120594" @default.
• W2096756834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7559782" @default.
• W2096756834 hasPublicationYear "1995" @default.
• W2096756834 type Work @default.
• W2096756834 sameAs 2096756834 @default.
• W2096756834 citedByCount "115" @default.
• W2096756834 countsByYear W20967568342012 @default.
• W2096756834 countsByYear W20967568342013 @default.
• W2096756834 countsByYear W20967568342014 @default.
• W2096756834 countsByYear W20967568342015 @default.
• W2096756834 countsByYear W20967568342017 @default.
• W2096756834 countsByYear W20967568342019 @default.
• W2096756834 countsByYear W20967568342020 @default.
• W2096756834 countsByYear W20967568342022 @default.
• W2096756834 countsByYear W20967568342023 @default.
• W2096756834 crossrefType "journal-article" @default.
• W2096756834 hasAuthorship W2096756834A5007446364 @default.
• W2096756834 hasAuthorship W2096756834A5037381969 @default.
• W2096756834 hasAuthorship W2096756834A5045676857 @default.
• W2096756834 hasAuthorship W2096756834A5061490638 @default.
• W2096756834 hasAuthorship W2096756834A5071741692 @default.
• W2096756834 hasAuthorship W2096756834A5091856094 @default.
• W2096756834 hasBestOaLocation W20967568341 @default.
• W2096756834 hasConcept C1009742 @default.
• W2096756834 hasConcept C1491633281 @default.
• W2096756834 hasConcept C150555746 @default.
• W2096756834 hasConcept C153911025 @default.
• W2096756834 hasConcept C16224149 @default.
• W2096756834 hasConcept C170493617 @default.
• W2096756834 hasConcept C55493867 @default.
• W2096756834 hasConcept C62112901 @default.
• W2096756834 hasConcept C62478195 @default.
• W2096756834 hasConcept C64979461 @default.
• W2096756834 hasConcept C79879829 @default.
• W2096756834 hasConcept C85528070 @default.
• W2096756834 hasConcept C85789140 @default.
• W2096756834 hasConcept C86803240 @default.
• W2096756834 hasConcept C95444343 @default.
• W2096756834 hasConceptScore W2096756834C1009742 @default.
• W2096756834 hasConceptScore W2096756834C1491633281 @default.
• W2096756834 hasConceptScore W2096756834C150555746 @default.
• W2096756834 hasConceptScore W2096756834C153911025 @default.
• W2096756834 hasConceptScore W2096756834C16224149 @default.
• W2096756834 hasConceptScore W2096756834C170493617 @default.
• W2096756834 hasConceptScore W2096756834C55493867 @default.
• W2096756834 hasConceptScore W2096756834C62112901 @default.
• W2096756834 hasConceptScore W2096756834C62478195 @default.
• W2096756834 hasConceptScore W2096756834C64979461 @default.
• W2096756834 hasConceptScore W2096756834C79879829 @default.
• W2096756834 hasConceptScore W2096756834C85528070 @default.
• W2096756834 hasConceptScore W2096756834C85789140 @default.
• W2096756834 hasConceptScore W2096756834C86803240 @default.
• W2096756834 hasConceptScore W2096756834C95444343 @default.
• W2096756834 hasIssue "1" @default.
• W2096756834 hasLocation W20967568341 @default.
• W2096756834 hasLocation W20967568342 @default.
• W2096756834 hasLocation W20967568343 @default.
• W2096756834 hasLocation W20967568344 @default.
• W2096756834 hasOpenAccess W2096756834 @default.
• W2096756834 hasPrimaryLocation W20967568341 @default.
• W2096756834 hasRelatedWork W1517312396 @default.
• W2096756834 hasRelatedWork W1790932677 @default.
• W2096756834 hasRelatedWork W2004997414 @default.
• W2096756834 hasRelatedWork W2014119293 @default.
• W2096756834 hasRelatedWork W2048760358 @default.
• W2096756834 hasRelatedWork W2070206351 @default.
• W2096756834 hasRelatedWork W2083693850 @default.

• next