FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096772012> ?p ?o ?g. }

• W2096772012 endingPage "473" @default.
• W2096772012 startingPage "466" @default.
• W2096772012 abstract "Altered cardiac metabolism and function (diabetic cardiomyopathy) has been observed in diabetes. We hypothesize that cardiac efficiency, the ratio of cardiac work (pressure-volume area [PVA]) and myocardial oxygen consumption (MVo2), is reduced in diabetic hearts. Experiments used ex vivo working hearts from control db/+, db/db (type 2 diabetes), and db/+ mice given streptozotocin (STZ; type 1 diabetes). PVA and ventricular function were assessed with a 1.4-F pressure-volume catheter at low (0.3 mmol/l) and high (1.4 mmol/l) fatty acid concentrations with simultaneous measurements of MVo2. Substrate oxidation and mitochondrial respiration were measured in separate experiments. Diabetic hearts showed decreased cardiac efficiency, revealed as an 86 and 57% increase in unloaded MVo2 in db/db and STZ-administered hearts, respectively. The slope of the PVA-MVo2 regression line was increased for db/db hearts after elevation of fatty acids, suggesting that contractile inefficiency could also contribute to the overall reduction in cardiac efficiency. The end-diastolic and end-systolic pressure-volume relationships in db/db hearts were shifted to the left with elevated end-diastolic pressure, suggesting left ventricular remodeling and/or myocardial stiffness. Thus, by means of pressure-volume technology, we have for the first time documented decreased cardiac efficiency in diabetic hearts caused by oxygen waste for noncontractile purposes." @default.
• W2096772012 created "2016-06-24" @default.
• W2096772012 creator A5003141541 @default.
• W2096772012 creator A5010203164 @default.
• W2096772012 creator A5014232110 @default.
• W2096772012 creator A5040595417 @default.
• W2096772012 creator A5059105070 @default.
• W2096772012 creator A5091348899 @default.
• W2096772012 date "2006-02-01" @default.
• W2096772012 modified "2023-10-11" @default.
• W2096772012 title "Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice" @default.
• W2096772012 cites W1570914098 @default.
• W2096772012 cites W1775749144 @default.
• W2096772012 cites W177640679 @default.
• W2096772012 cites W1994889733 @default.
• W2096772012 cites W2001913231 @default.
• W2096772012 cites W2003068122 @default.
• W2096772012 cites W2005197044 @default.
• W2096772012 cites W2007857289 @default.
• W2096772012 cites W2018510874 @default.
• W2096772012 cites W2019454427 @default.
• W2096772012 cites W2058536977 @default.
• W2096772012 cites W2059736719 @default.
• W2096772012 cites W2069689528 @default.
• W2096772012 cites W2097364562 @default.
• W2096772012 cites W2098612318 @default.
• W2096772012 cites W2114215010 @default.
• W2096772012 cites W2128140020 @default.
• W2096772012 cites W2144766505 @default.
• W2096772012 cites W2149657149 @default.
• W2096772012 cites W2150336836 @default.
• W2096772012 cites W2155351425 @default.
• W2096772012 cites W2161390320 @default.
• W2096772012 cites W2165425998 @default.
• W2096772012 cites W2182206101 @default.
• W2096772012 cites W2215667781 @default.
• W2096772012 cites W2256077311 @default.
• W2096772012 doi "https://doi.org/10.2337/diabetes.55.02.06.db05-1164" @default.
• W2096772012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16443782" @default.
• W2096772012 hasPublicationYear "2006" @default.
• W2096772012 type Work @default.
• W2096772012 sameAs 2096772012 @default.
• W2096772012 citedByCount "226" @default.
• W2096772012 countsByYear W20967720122012 @default.
• W2096772012 countsByYear W20967720122013 @default.
• W2096772012 countsByYear W20967720122014 @default.
• W2096772012 countsByYear W20967720122015 @default.
• W2096772012 countsByYear W20967720122016 @default.
• W2096772012 countsByYear W20967720122017 @default.
• W2096772012 countsByYear W20967720122018 @default.
• W2096772012 countsByYear W20967720122019 @default.
• W2096772012 countsByYear W20967720122020 @default.
• W2096772012 countsByYear W20967720122021 @default.
• W2096772012 countsByYear W20967720122022 @default.
• W2096772012 countsByYear W20967720122023 @default.
• W2096772012 crossrefType "journal-article" @default.
• W2096772012 hasAuthorship W2096772012A5003141541 @default.
• W2096772012 hasAuthorship W2096772012A5010203164 @default.
• W2096772012 hasAuthorship W2096772012A5014232110 @default.
• W2096772012 hasAuthorship W2096772012A5040595417 @default.
• W2096772012 hasAuthorship W2096772012A5059105070 @default.
• W2096772012 hasAuthorship W2096772012A5091348899 @default.
• W2096772012 hasBestOaLocation W20967720121 @default.
• W2096772012 hasConcept C111566952 @default.
• W2096772012 hasConcept C126322002 @default.
• W2096772012 hasConcept C134018914 @default.
• W2096772012 hasConcept C164705383 @default.
• W2096772012 hasConcept C178853913 @default.
• W2096772012 hasConcept C2776553924 @default.
• W2096772012 hasConcept C2778198053 @default.
• W2096772012 hasConcept C2778797674 @default.
• W2096772012 hasConcept C2779280383 @default.
• W2096772012 hasConcept C48277249 @default.
• W2096772012 hasConcept C555293320 @default.
• W2096772012 hasConcept C57900726 @default.
• W2096772012 hasConcept C71924100 @default.
• W2096772012 hasConcept C84393581 @default.
• W2096772012 hasConceptScore W2096772012C111566952 @default.
• W2096772012 hasConceptScore W2096772012C126322002 @default.
• W2096772012 hasConceptScore W2096772012C134018914 @default.
• W2096772012 hasConceptScore W2096772012C164705383 @default.
• W2096772012 hasConceptScore W2096772012C178853913 @default.
• W2096772012 hasConceptScore W2096772012C2776553924 @default.
• W2096772012 hasConceptScore W2096772012C2778198053 @default.
• W2096772012 hasConceptScore W2096772012C2778797674 @default.
• W2096772012 hasConceptScore W2096772012C2779280383 @default.
• W2096772012 hasConceptScore W2096772012C48277249 @default.
• W2096772012 hasConceptScore W2096772012C555293320 @default.
• W2096772012 hasConceptScore W2096772012C57900726 @default.
• W2096772012 hasConceptScore W2096772012C71924100 @default.
• W2096772012 hasConceptScore W2096772012C84393581 @default.
• W2096772012 hasIssue "2" @default.
• W2096772012 hasLocation W20967720121 @default.
• W2096772012 hasLocation W20967720122 @default.
• W2096772012 hasOpenAccess W2096772012 @default.
• W2096772012 hasPrimaryLocation W20967720121 @default.
• W2096772012 hasRelatedWork W169677309 @default.
• W2096772012 hasRelatedWork W2009856482 @default.

• next