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W2096810018 abstract "Treatment-resistant hypertension is a recognized clinical challenge and renal sympathetic denervation (RSD) represents a new frontier of this treatment [ 1 Stefanadis C. Synetos A. Toutouzas K. et al. Barodenervation of the sympathetic nervous system of the renal artery. A new concept. Int J Cardiol. Oct 9 2013; 168: 4443-4444 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar , 2 Doumas M. Faselis C. Papademetriou V. Renal sympathetic denervation and systemic hypertension. Am J Cardiol. Feb 15 2010; 105: 570-576 Abstract Full Text Full Text PDF PubMed Scopus (64) Google Scholar , 3 Froeschl M. Hadziomerovic A. Ruzicka M. Renal sympathetic denervation for resistant hypertension. Can J Cardiol. May 2013; 29 ([Review]): 636-638 Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar , 4 Simonyi G. Bedros J.R. Medvegy M. Instrumental therapy of drug-resistant hypertension. Orv Hetil. Feb 10 2013; 154 (Review.): 203-208 Crossref PubMed Google Scholar , 5 Prochnau D. Heymel S. Göbel B. Figulla H.R. Surber R. Resistant hypertension: multivariate predictors of blood pressure response to renal denervation. Int J Cardiol. Oct 3 2013; 168: 3130-3132 Abstract Full Text Full Text PDF PubMed Scopus (14) Google Scholar , 6 Schlaich M.P. Bart B. Hering D. et al. Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with endstage renal disease. Int J Cardiol. Oct 3 2013; 168: 2214-2220 Abstract Full Text Full Text PDF PubMed Scopus (109) Google Scholar , 7 Davies J.E. Manisty C.H. Petraco R. et al. First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study. Int J Cardiol. Jan 20 2013; 162: 189-192 Abstract Full Text Full Text PDF PubMed Scopus (225) Google Scholar , 8 Tam G.M. Yan B.P. Shetty S.V. Lam Y.Y. Transcatheter renal artery sympathetic denervation for resistant hypertension: an old paradigm revisited. Int J Cardiol. Apr 15 2013; 164: 277-281 Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar , 9 Zhao Q. Yu S. Huang H. et al. Effects of renal sympathetic denervation on the development of atrial fibrillation substrates in dogs with pacing-induced heart failure. Int J Cardiol. Sep 30 2013; 168: 1672-1673 Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar , 10 Saitta A. Saitta M.N. Messina A. et al. Effects of adrenergic stimulation on transmembrane transport of Na+ in patients with essential hypertension. Minerva Med. Jul–Aug 1997; 88 ([Italian]): 275-282 PubMed Google Scholar , 11 Patanè S. Marte F. Sturiale M. Dattilo G. Luzza F. Atrial flutter, ventricular tachycardia and changing axis deviation associated with scleroderma. Int J Cardiol. Dec 1 2011; 153: e25-e28 Abstract Full Text Full Text PDF PubMed Scopus (23) Google Scholar , 12 Patanè S. 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Jan 20 2013; 162: e58-e59 Abstract Full Text Full Text PDF PubMed Scopus (19) Google Scholar ]. Patients with treatment-resistant hypertension are at high risk of cardiac complications, valvular complications, vascular complications, cerebrovascular and renal complications [ 20 Saitta A. Sardo A. Bonaiuto M. et al. Effects of picotamide on release of endothelin-1, thromboxane and prostacycline after treadmill stress in patients with peripheral artery disease. Angiology. Nov 1998; 49: 879-884 Crossref PubMed Scopus (5) Google Scholar , 21 Patanè S. Marte F. Sturiale M. Dattilo G. ST-segment elevation and diminution of prostate-specific antigen in a patient with coronary spasm and without significant coronary stenoses. Int J Cardiol. Apr 14 2011; 148: e31-e33 Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar , 22 Dattilo G. Tulino V. Tulino D. Lamari A. Marte F. Patanè S. 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Int J Cardiol. 2013 Oct 12; 168: 4969-4970 Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar ]. A 52-year-old woman with a history of severe hypertension was taking seven antihypertensive drugs [ 27 Mandraffino G. Sardo M.A. Riggio S. et al. Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness. Hypertens Res. Jul 2011; 34: 876-883 Crossref PubMed Scopus (34) Google Scholar , 28 Sardo M.A. Mandraffino G. Campo S. et al. Clin Chim Acta. Aug 2009; 406: 89-93 Crossref PubMed Scopus (27) Google Scholar , 29 Sardo M.A. Mandraffino G. Riggio S. et al. Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients. Clin Exp Pharmacol Physiol. Sep 2010; 37: 933-938 Crossref PubMed Scopus (25) Google Scholar , 30 Mandraffino G. Sardo M.A. Riggio S. et al. Smoke exposure and circulating progenitor cells: evidence for modulation of antioxidant enzymes and cell count. Clin Biochem. Dec 2010; 43: 1436-1442 Crossref PubMed Scopus (40) Google Scholar ]. We excluded causes of secondary hypertension and have recommended RSD (state-of-the-art: percutaneous technique, catheter-based radiofrequency ablation). Selective angiography of renal artery was performed. The results showed the main and accessory right artery (Fig. 1A and B ), and the main left renal artery (Fig. 1C). We then proceeded to the RSD. The Symplicity catheter [ [31] Symplicity HTN-2 Investigators Esler M.D. Krum H. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomized controlled trial. Lancet. 2010; 376: 1903-1989 Abstract Full Text Full Text PDF PubMed Scopus (1839) Google Scholar ] was advanced into the renal artery. Six ablations with spiral technique every 2 min were applied along the length of the renal arteries, for a total eighteen points in a single session. After ablation, BP dropped to 150/80 mm Hg. On day 3 after admission without any complication, the patient was discharged from the hospital with medical therapy reduced by half. After ambulatory blood pressure monitoring for 3 months, was suggested drug therapy with single drug. This case demonstrates a successful RSD (advantageous technique, minimally invasive and devoid of the adverse effects), but we await the follow-up of the medium-long term [ 32 Baumbach A. Burchell A.E. Hart E.C. Nightingale A.K. Paton J.F. Normal range sympathetic tone in resistant hypertension associatedwith blood pressure increase following renal denervation in a pre-menopausal woman. Int J Cardiol. Sep 10 2013; 167: e190-e191 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar , 33 Prochnau D. Figulla H.R. Surber R. Cryoenergy is effective in the treatment of resistant hypertension in non-responders to radiofrequency renal denervation. Int J Cardiol. Jul 31 2013; 167: 588-590 Abstract Full Text Full Text PDF PubMed Scopus (16) Google Scholar , 34 Ukena C. Mahfoud F. Spies A. et al. Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension. Int J Cardiol. 2013 Sep 10; 167: 2846-2851 Abstract Full Text Full Text PDF PubMed Scopus (100) Google Scholar , 35 Prochnau D. Figulla H.R. Surber R. Efficacy of renal denervation with a standard EP catheter in the 24-h ambulatory blood pressure monitoring-long-term follow-up. Int J Cardiol. Jun 14 2012; 157: 447-448 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar ]." @default.
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W2096810018 title "Renal denervation and hypertension resistant drug treatment in patient with renal artery accessory" @default.
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