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- W2096833139 abstract "The effect of surface-potential modulators on palmitate/Ca 2+ -induced formation of lipid pores was studied in liposomal and inner mitochondrial membranes. Pore formation was monitored by sulforhodamine B release from liposomes and swelling of mitochondria. ζ-potential in liposomes was determined from electrophoretic mobility. Replacement of sucrose as the osmotic agent with KCl decreased negative ζ-potential in liposomes and increased resistance of both mitochondria and liposomes to the pore inducers, palmitic acid, and Ca 2+ . Micromolar Mg 2+ also inhibited palmitate/Ca 2+ -induced permeabilization of liposomes. The rate of palmitate/Ca 2+ -induced, cyclosporin A-insensitive swelling of mitochondria increased 22% upon increasing pH from 7.0 to 7.8. At below the critical micelle concentration, the cationic detergent cetyltrimethylammonium bromide (10 μM) and the anionic surfactant sodium dodecylsulfate (10–50 μM) made the ζ-potential less and more negative, respectively, and inhibited and stimulated opening of mitochondrial palmitate/Ca 2 + -induced lipid pores. Taken together, the findings indicate that surface potential regulates palmitate/Ca 2+ -induced lipid pore opening. • High ionic strength and Mg 2 + inhibit formation of pores in mitochondria and liposomes • Raising pH of the medium stimulates opening of the pore in mitochondria • CTAB inhibits and SDS stimulates formation of pores in liposomes and mitochondria • Negative ξ-potential facilitates opening of the pore in membranes" @default.
- W2096833139 created "2016-06-24" @default.
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- W2096833139 date "2015-10-01" @default.
- W2096833139 modified "2023-10-17" @default.
- W2096833139 title "Effect of surface-potential modulators on the opening of lipid pores in liposomal and mitochondrial inner membranes induced by palmitate and calcium ions" @default.
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- W2096833139 doi "https://doi.org/10.1016/j.bbamem.2015.05.013" @default.
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