FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096834319> ?p ?o ?g. }

• W2096834319 endingPage "1433" @default.
• W2096834319 startingPage "1422" @default.
• W2096834319 abstract "Abstract Most of our understanding of the development and phenotype of alternatively activated macrophages (AAMs) has been obtained from studies investigating the response of bone marrow- and peritoneal-derived cells to IL-4 or IL-13 stimulation. Comparatively little is known about the development of AAMs in the lungs, and how the complex signals associated with pulmonary inflammation influence the AAM phenotype. Here, we use Nippostrongylus brasiliensis to initiate AAM development and define the dynamics of surface molecules, gene expression, and cell function of macrophages isolated from lung tissue at different times postinfection (PI). Initially, lung macrophages take on a foamy phenotype, up-regulate MHC and costimulatory molecules, express reduced levels of TNF and IL-12, and undergo proliferation. Cells isolated between days 8 and 15 PI adopt a dense, granular phenotype and exhibit reduced levels of costimulatory molecules and elevated levels of programmed death ligand-1 (PDL-1) and PDL-2 and an increase in IL-10 expression. Functionally, AAMs isolated on days 13–15 PI demonstrate an enhanced capacity to take up and sequester antigen. However, these same cells did not mediate antigen-specific T cell proliferation and dampened the proliferation of CD3/CD28-activated CD4+ T cells. These data indicate that the alternative activation of macrophages in the lungs, although initiated by IL-4/IL-13, is a dynamic process that is likely to be influenced by other immune and nonimmune factors in the pulmonary environment." @default.
• W2096834319 created "2016-06-24" @default.
• W2096834319 creator A5001769876 @default.
• W2096834319 creator A5016656665 @default.
• W2096834319 creator A5023495081 @default.
• W2096834319 creator A5077356473 @default.
• W2096834319 date "2008-08-21" @default.
• W2096834319 modified "2023-10-18" @default.
• W2096834319 title "Dynamics of lung macrophage activation in response to helminth infection" @default.
• W2096834319 cites W1513634422 @default.
• W2096834319 cites W1555650656 @default.
• W2096834319 cites W1583619539 @default.
• W2096834319 cites W1604090940 @default.
• W2096834319 cites W1621676818 @default.
• W2096834319 cites W1774233069 @default.
• W2096834319 cites W1853452392 @default.
• W2096834319 cites W1929879919 @default.
• W2096834319 cites W1961573346 @default.
• W2096834319 cites W1972416794 @default.
• W2096834319 cites W1977267646 @default.
• W2096834319 cites W1982483409 @default.
• W2096834319 cites W1983831001 @default.
• W2096834319 cites W1985096978 @default.
• W2096834319 cites W1998012803 @default.
• W2096834319 cites W2000562317 @default.
• W2096834319 cites W2006982615 @default.
• W2096834319 cites W2008106399 @default.
• W2096834319 cites W2009170266 @default.
• W2096834319 cites W2017703216 @default.
• W2096834319 cites W2025131995 @default.
• W2096834319 cites W2030697288 @default.
• W2096834319 cites W2032474425 @default.
• W2096834319 cites W2033547663 @default.
• W2096834319 cites W2033796232 @default.
• W2096834319 cites W2033868174 @default.
• W2096834319 cites W2035141288 @default.
• W2096834319 cites W2037189049 @default.
• W2096834319 cites W2037323507 @default.
• W2096834319 cites W2038689279 @default.
• W2096834319 cites W2042354033 @default.
• W2096834319 cites W2048851534 @default.
• W2096834319 cites W2055402867 @default.
• W2096834319 cites W2057661387 @default.
• W2096834319 cites W2062767382 @default.
• W2096834319 cites W2066060929 @default.
• W2096834319 cites W2072628757 @default.
• W2096834319 cites W2073541049 @default.
• W2096834319 cites W2080911945 @default.
• W2096834319 cites W2100723554 @default.
• W2096834319 cites W2101436464 @default.
• W2096834319 cites W2102170885 @default.
• W2096834319 cites W2104260741 @default.
• W2096834319 cites W2104662295 @default.
• W2096834319 cites W2107790283 @default.
• W2096834319 cites W2109958057 @default.
• W2096834319 cites W2110279016 @default.
• W2096834319 cites W2112284938 @default.
• W2096834319 cites W2118751252 @default.
• W2096834319 cites W2121135409 @default.
• W2096834319 cites W2122635906 @default.
• W2096834319 cites W2123659126 @default.
• W2096834319 cites W2128444087 @default.
• W2096834319 cites W2134046076 @default.
• W2096834319 cites W2136287630 @default.
• W2096834319 cites W2141009231 @default.
• W2096834319 cites W2143043043 @default.
• W2096834319 cites W2143500103 @default.
• W2096834319 cites W2147754351 @default.
• W2096834319 cites W2152215671 @default.
• W2096834319 cites W2161354474 @default.
• W2096834319 cites W2162196121 @default.
• W2096834319 cites W2162742393 @default.
• W2096834319 cites W2166189303 @default.
• W2096834319 cites W2167485774 @default.
• W2096834319 cites W2167933104 @default.
• W2096834319 cites W2168203604 @default.
• W2096834319 cites W2170851221 @default.
• W2096834319 cites W2170948066 @default.
• W2096834319 doi "https://doi.org/10.1189/jlb.0308199" @default.
• W2096834319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2614596" @default.
• W2096834319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18719016" @default.
• W2096834319 hasPublicationYear "2008" @default.
• W2096834319 type Work @default.
• W2096834319 sameAs 2096834319 @default.
• W2096834319 citedByCount "60" @default.
• W2096834319 countsByYear W20968343192012 @default.
• W2096834319 countsByYear W20968343192013 @default.
• W2096834319 countsByYear W20968343192014 @default.
• W2096834319 countsByYear W20968343192015 @default.
• W2096834319 countsByYear W20968343192016 @default.
• W2096834319 countsByYear W20968343192017 @default.
• W2096834319 countsByYear W20968343192018 @default.
• W2096834319 countsByYear W20968343192021 @default.
• W2096834319 countsByYear W20968343192022 @default.
• W2096834319 crossrefType "journal-article" @default.
• W2096834319 hasAuthorship W2096834319A5001769876 @default.
• W2096834319 hasAuthorship W2096834319A5016656665 @default.
• W2096834319 hasAuthorship W2096834319A5023495081 @default.

• next