Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096856323> ?p ?o ?g. }
- W2096856323 endingPage "1055" @default.
- W2096856323 startingPage "1055" @default.
- W2096856323 abstract "Proliferative vitreoretinopathy (PVR) develops as a complication of rhegmatogenous retinal detachment (RRD). The unclear pathological pathways of PVR and RRD have been the biggest obstacle for successful retinal reattachment. In this study, a metabolomics approach using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was developed to obtain a systematic view of the pathological processes of RRD and PVR. Through a partial least squares discriminant analysis (PLS-DA) method, 31 biomarkers were identified in the vitreous samples of RRD and PVR patients. Sixteen pathways participated in the development of RRD and PVR. Through analyzing the biological effects of those identified biomarkers, inflammation, proliferation and energy consumption were the three major disturbed biological processes involved in the RRD and PVR development. Inflammation happened in the pathological processes of RRD, and proliferation mainly happened during PVR formation. The established network of biomarkers indicated that the histidine metabolism and citrate cycle were seriously disturbed during the RRD and PVR development. The metabolomics study supplied a systematic view of the development and progression of RRD and PVR on a metabolite level." @default.
- W2096856323 created "2016-06-24" @default.
- W2096856323 creator A5011156551 @default.
- W2096856323 creator A5012297820 @default.
- W2096856323 creator A5032484844 @default.
- W2096856323 creator A5056769686 @default.
- W2096856323 creator A5074131698 @default.
- W2096856323 creator A5090097840 @default.
- W2096856323 date "2014-01-01" @default.
- W2096856323 modified "2023-09-30" @default.
- W2096856323 title "Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis" @default.
- W2096856323 cites W1509926796 @default.
- W2096856323 cites W1533219941 @default.
- W2096856323 cites W1555033960 @default.
- W2096856323 cites W1967074745 @default.
- W2096856323 cites W1968813633 @default.
- W2096856323 cites W1969889522 @default.
- W2096856323 cites W1970531479 @default.
- W2096856323 cites W1974873484 @default.
- W2096856323 cites W1975579196 @default.
- W2096856323 cites W1994914347 @default.
- W2096856323 cites W2003414488 @default.
- W2096856323 cites W2004585784 @default.
- W2096856323 cites W2007738633 @default.
- W2096856323 cites W2011375826 @default.
- W2096856323 cites W2019106819 @default.
- W2096856323 cites W2022631085 @default.
- W2096856323 cites W2022926874 @default.
- W2096856323 cites W2028478762 @default.
- W2096856323 cites W2042130969 @default.
- W2096856323 cites W2049490102 @default.
- W2096856323 cites W2052310251 @default.
- W2096856323 cites W2071588610 @default.
- W2096856323 cites W2084775283 @default.
- W2096856323 cites W2087969278 @default.
- W2096856323 cites W2095505248 @default.
- W2096856323 cites W2107361820 @default.
- W2096856323 cites W2114232337 @default.
- W2096856323 cites W2128163974 @default.
- W2096856323 cites W2155019246 @default.
- W2096856323 cites W2317611716 @default.
- W2096856323 doi "https://doi.org/10.1039/c3mb70386j" @default.
- W2096856323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24556753" @default.
- W2096856323 hasPublicationYear "2014" @default.
- W2096856323 type Work @default.
- W2096856323 sameAs 2096856323 @default.
- W2096856323 citedByCount "32" @default.
- W2096856323 countsByYear W20968563232014 @default.
- W2096856323 countsByYear W20968563232015 @default.
- W2096856323 countsByYear W20968563232016 @default.
- W2096856323 countsByYear W20968563232017 @default.
- W2096856323 countsByYear W20968563232018 @default.
- W2096856323 countsByYear W20968563232019 @default.
- W2096856323 countsByYear W20968563232020 @default.
- W2096856323 countsByYear W20968563232021 @default.
- W2096856323 countsByYear W20968563232022 @default.
- W2096856323 countsByYear W20968563232023 @default.
- W2096856323 crossrefType "journal-article" @default.
- W2096856323 hasAuthorship W2096856323A5011156551 @default.
- W2096856323 hasAuthorship W2096856323A5012297820 @default.
- W2096856323 hasAuthorship W2096856323A5032484844 @default.
- W2096856323 hasAuthorship W2096856323A5056769686 @default.
- W2096856323 hasAuthorship W2096856323A5074131698 @default.
- W2096856323 hasAuthorship W2096856323A5090097840 @default.
- W2096856323 hasConcept C118487528 @default.
- W2096856323 hasConcept C126322002 @default.
- W2096856323 hasConcept C185592680 @default.
- W2096856323 hasConcept C21565614 @default.
- W2096856323 hasConcept C2776914184 @default.
- W2096856323 hasConcept C2779059073 @default.
- W2096856323 hasConcept C2780428090 @default.
- W2096856323 hasConcept C2780827179 @default.
- W2096856323 hasConcept C43617362 @default.
- W2096856323 hasConcept C71924100 @default.
- W2096856323 hasConceptScore W2096856323C118487528 @default.
- W2096856323 hasConceptScore W2096856323C126322002 @default.
- W2096856323 hasConceptScore W2096856323C185592680 @default.
- W2096856323 hasConceptScore W2096856323C21565614 @default.
- W2096856323 hasConceptScore W2096856323C2776914184 @default.
- W2096856323 hasConceptScore W2096856323C2779059073 @default.
- W2096856323 hasConceptScore W2096856323C2780428090 @default.
- W2096856323 hasConceptScore W2096856323C2780827179 @default.
- W2096856323 hasConceptScore W2096856323C43617362 @default.
- W2096856323 hasConceptScore W2096856323C71924100 @default.
- W2096856323 hasIssue "5" @default.
- W2096856323 hasLocation W20968563231 @default.
- W2096856323 hasLocation W20968563232 @default.
- W2096856323 hasOpenAccess W2096856323 @default.
- W2096856323 hasPrimaryLocation W20968563231 @default.
- W2096856323 hasRelatedWork W1981835586 @default.
- W2096856323 hasRelatedWork W1996807476 @default.
- W2096856323 hasRelatedWork W2005639104 @default.
- W2096856323 hasRelatedWork W2064353298 @default.
- W2096856323 hasRelatedWork W2392856685 @default.
- W2096856323 hasRelatedWork W2416026931 @default.
- W2096856323 hasRelatedWork W2602800374 @default.
- W2096856323 hasRelatedWork W2794073754 @default.
- W2096856323 hasRelatedWork W2899011017 @default.