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- W2096861863 abstract "ABSTRACT We have determined the sequence of the gene cluster encoding the O antigen in Francisella novicida and compared it to the previously reported O-antigen cluster in Francisella tularensis subsp. tularensis . Immunization with purified lipopolysaccharide (LPS) from F. tularensis subsp. tularensis or F. novicida protected against challenge with Francisella tularensis subsp. holarctica and F. novicida , respectively. The LPS from F. tularensis subsp. tularensis did not confer protection against challenge with F. novicida , and the LPS from F. novicida did not confer protection against challenge with F. tularensis subsp. holarctica . Allelic replacement mutants of F. tularensis subsp. tularensis or F. novicida which failed to produce O antigen were attenuated, but exposure to these mutants did not induce a protective immune response. The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival." @default.
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- W2096861863 date "2007-01-01" @default.
- W2096861863 modified "2023-10-14" @default.
- W2096861863 title "The Immunologically Distinct O Antigens from<i>Francisella tularensis</i>Subspecies<i>tularensis</i>and<i>Francisella novicida</i>Are both Virulence Determinants and Protective Antigens" @default.
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- W2096861863 doi "https://doi.org/10.1128/iai.01241-06" @default.
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