FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096863173> ?p ?o ?g. }

• W2096863173 endingPage "746" @default.
• W2096863173 startingPage "742" @default.
• W2096863173 abstract "Eight naturally purified microcystins (MCs), including MC-LR, -FR, -WR, -RR, [d-Asp3]MC-FR, -WR, -RR, and [Dha7]MC-RR were utilized to determine the effects of amino acid substitutions and modifications on MC-induced protein phosphatase inhibition activity and mouse toxicity. Catalytic subunits of protein phosphatase 1 (PP-1) and 2A (PP-2A) were purified and subjected to the inhibition assays, and intraperitoneal injection was used to administer MCs into mice for the toxicity assay. It is found that the replacement of the non-polar amino acid l-leucine at the second position of these heptacyclic peptide toxins by a polar l-arginine reduces their mouse toxicities and inhibitory activities against PP-1 and PP-2A to different extends. Demethylation of methyldehydroalanine (Mdha) at the seventh amino acid of MC-RR exhibits the least mouse toxicity and phosphatase inhibition. The loss of a methyl group on the common methylaspartic acid (MeAsp) at the third position of MC-FR, -WR, and -RR does not alter their toxicity levels, but dominantly reduces their activities in PP-1 inhibition compared to other substitutions or modifications. This suggests that the methyl group on MeAsp is also important for MCs inhibition. However, such a tendency is not observed for PP-2A. By comparing the LD50 values of the mouse toxicity assay and IC50 values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity." @default.
• W2096863173 created "2016-06-24" @default.
• W2096863173 creator A5001599513 @default.
• W2096863173 creator A5003958446 @default.
• W2096863173 creator A5007558049 @default.
• W2096863173 creator A5028928368 @default.
• W2096863173 creator A5066776951 @default.
• W2096863173 creator A5070810100 @default.
• W2096863173 date "2006-06-01" @default.
• W2096863173 modified "2023-10-03" @default.
• W2096863173 title "Comparison of protein phosphatase inhibition activities and mouse toxicities of microcystins" @default.
• W2096863173 cites W1496832150 @default.
• W2096863173 cites W1892570697 @default.
• W2096863173 cites W1966266025 @default.
• W2096863173 cites W1969173610 @default.
• W2096863173 cites W1970207313 @default.
• W2096863173 cites W1972729306 @default.
• W2096863173 cites W1989911861 @default.
• W2096863173 cites W2004775204 @default.
• W2096863173 cites W2014571267 @default.
• W2096863173 cites W2031535323 @default.
• W2096863173 cites W2056256363 @default.
• W2096863173 cites W2066893159 @default.
• W2096863173 cites W2074503341 @default.
• W2096863173 cites W2074525235 @default.
• W2096863173 cites W2080521862 @default.
• W2096863173 cites W2117593422 @default.
• W2096863173 cites W2178456244 @default.
• W2096863173 doi "https://doi.org/10.1016/j.toxicon.2006.01.026" @default.
• W2096863173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16684551" @default.
• W2096863173 hasPublicationYear "2006" @default.
• W2096863173 type Work @default.
• W2096863173 sameAs 2096863173 @default.
• W2096863173 citedByCount "54" @default.
• W2096863173 countsByYear W20968631732012 @default.
• W2096863173 countsByYear W20968631732013 @default.
• W2096863173 countsByYear W20968631732014 @default.
• W2096863173 countsByYear W20968631732015 @default.
• W2096863173 countsByYear W20968631732016 @default.
• W2096863173 countsByYear W20968631732017 @default.
• W2096863173 countsByYear W20968631732018 @default.
• W2096863173 countsByYear W20968631732019 @default.
• W2096863173 countsByYear W20968631732020 @default.
• W2096863173 countsByYear W20968631732021 @default.
• W2096863173 countsByYear W20968631732022 @default.
• W2096863173 countsByYear W20968631732023 @default.
• W2096863173 crossrefType "journal-article" @default.
• W2096863173 hasAuthorship W2096863173A5001599513 @default.
• W2096863173 hasAuthorship W2096863173A5003958446 @default.
• W2096863173 hasAuthorship W2096863173A5007558049 @default.
• W2096863173 hasAuthorship W2096863173A5028928368 @default.
• W2096863173 hasAuthorship W2096863173A5066776951 @default.
• W2096863173 hasAuthorship W2096863173A5070810100 @default.
• W2096863173 hasBestOaLocation W20968631732 @default.
• W2096863173 hasConcept C104317684 @default.
• W2096863173 hasConcept C116263406 @default.
• W2096863173 hasConcept C150194340 @default.
• W2096863173 hasConcept C160160445 @default.
• W2096863173 hasConcept C178666793 @default.
• W2096863173 hasConcept C178790620 @default.
• W2096863173 hasConcept C181199279 @default.
• W2096863173 hasConcept C185592680 @default.
• W2096863173 hasConcept C190727270 @default.
• W2096863173 hasConcept C202199734 @default.
• W2096863173 hasConcept C202751555 @default.
• W2096863173 hasConcept C21547065 @default.
• W2096863173 hasConcept C2776580952 @default.
• W2096863173 hasConcept C2777468819 @default.
• W2096863173 hasConcept C2777752497 @default.
• W2096863173 hasConcept C2779281246 @default.
• W2096863173 hasConcept C2779707156 @default.
• W2096863173 hasConcept C29730261 @default.
• W2096863173 hasConcept C389152 @default.
• W2096863173 hasConcept C515207424 @default.
• W2096863173 hasConcept C55493867 @default.
• W2096863173 hasConceptScore W2096863173C104317684 @default.
• W2096863173 hasConceptScore W2096863173C116263406 @default.
• W2096863173 hasConceptScore W2096863173C150194340 @default.
• W2096863173 hasConceptScore W2096863173C160160445 @default.
• W2096863173 hasConceptScore W2096863173C178666793 @default.
• W2096863173 hasConceptScore W2096863173C178790620 @default.
• W2096863173 hasConceptScore W2096863173C181199279 @default.
• W2096863173 hasConceptScore W2096863173C185592680 @default.
• W2096863173 hasConceptScore W2096863173C190727270 @default.
• W2096863173 hasConceptScore W2096863173C202199734 @default.
• W2096863173 hasConceptScore W2096863173C202751555 @default.
• W2096863173 hasConceptScore W2096863173C21547065 @default.
• W2096863173 hasConceptScore W2096863173C2776580952 @default.
• W2096863173 hasConceptScore W2096863173C2777468819 @default.
• W2096863173 hasConceptScore W2096863173C2777752497 @default.
• W2096863173 hasConceptScore W2096863173C2779281246 @default.
• W2096863173 hasConceptScore W2096863173C2779707156 @default.
• W2096863173 hasConceptScore W2096863173C29730261 @default.
• W2096863173 hasConceptScore W2096863173C389152 @default.
• W2096863173 hasConceptScore W2096863173C515207424 @default.
• W2096863173 hasConceptScore W2096863173C55493867 @default.
• W2096863173 hasIssue "7" @default.
• W2096863173 hasLocation W20968631731 @default.

• next