FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096871000> ?p ?o ?g. }

• W2096871000 endingPage "1570" @default.
• W2096871000 startingPage "1565" @default.
• W2096871000 abstract "<h3>Background:</h3> Although fluoroquinolones are sometimes associated with mild, transient elevations in aminotransferase levels, serious acute liver injury is uncommon. Regulatory warnings have identified moxifloxacin as presenting a particular risk of hepatotoxicity. Thus, we examined the risk of idiosyncratic acute liver injury associated with the use of moxifloxacin relative to other selected antibiotic agents. <h3>Methods:</h3> We conducted a population-based, nested, case–control study using health care data from Ontario for the period April 2002 to March 2011. We identified cases as outpatients aged 66 years or older with no history of liver disease, and who were admitted to hospital for acute liver injury within 30 days of receiving a prescription for 1 of 5 broad-spectrum antibiotic agents: moxifloxacin, levofloxacin, ciprofloxacin, cefuroxime axetil or clarithromycin. For each case, we selected up to 10 age- and sex-matched controls from among patients who had received a study antibiotic, but who were not admitted to hospital for acute liver injury. We calculated odds ratios (ORs) to determine the association between admission to hospital and previous exposure to an antibiotic agent, using clarithromycin as the reference. <h3>Results:</h3> A total of 144 patients were admitted to hospital for acute liver injury within 30 days of receiving a prescription for one of the identified drugs. Of these patients, 88 (61.1%) died while in hospital. After multivariable adjustment, use of either moxifloxacin (adjusted OR 2.20, 95% confidence interval [CI] 1.21–3.98) or levofloxacin (adjusted OR 1.85, 95% CI 1.01–3.39) was associated with an increase in risk of acute liver injury relative to the use of clarithromycin. We saw no such risk associated with the use of either ciprofloxacin or cefuroxime axetil. <h3>Interpretation:</h3> Among older outpatients with no evidence of liver disease, moxifloxacin and levofloxacin were associated with an increased risk of acute liver injury relative to clarithromycin." @default.
• W2096871000 created "2016-06-24" @default.
• W2096871000 creator A5031763103 @default.
• W2096871000 creator A5049307189 @default.
• W2096871000 creator A5065468510 @default.
• W2096871000 creator A5070399179 @default.
• W2096871000 date "2012-08-13" @default.
• W2096871000 modified "2023-10-17" @default.
• W2096871000 title "Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study" @default.
• W2096871000 cites W100013426 @default.
• W2096871000 cites W1483743166 @default.
• W2096871000 cites W1772740936 @default.
• W2096871000 cites W1968451120 @default.
• W2096871000 cites W1974886846 @default.
• W2096871000 cites W1975440270 @default.
• W2096871000 cites W1978351154 @default.
• W2096871000 cites W2028005470 @default.
• W2096871000 cites W2031364396 @default.
• W2096871000 cites W2048839381 @default.
• W2096871000 cites W2062783616 @default.
• W2096871000 cites W2068074724 @default.
• W2096871000 cites W2076490579 @default.
• W2096871000 cites W2099753110 @default.
• W2096871000 cites W2110102664 @default.
• W2096871000 cites W2111945961 @default.
• W2096871000 cites W2133329506 @default.
• W2096871000 cites W2141474943 @default.
• W2096871000 cites W2148122888 @default.
• W2096871000 cites W2155308279 @default.
• W2096871000 doi "https://doi.org/10.1503/cmaj.111823" @default.
• W2096871000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3470619" @default.
• W2096871000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22891208" @default.
• W2096871000 hasPublicationYear "2012" @default.
• W2096871000 type Work @default.
• W2096871000 sameAs 2096871000 @default.
• W2096871000 citedByCount "47" @default.
• W2096871000 countsByYear W20968710002012 @default.
• W2096871000 countsByYear W20968710002013 @default.
• W2096871000 countsByYear W20968710002014 @default.
• W2096871000 countsByYear W20968710002015 @default.
• W2096871000 countsByYear W20968710002016 @default.
• W2096871000 countsByYear W20968710002017 @default.
• W2096871000 countsByYear W20968710002018 @default.
• W2096871000 countsByYear W20968710002019 @default.
• W2096871000 countsByYear W20968710002020 @default.
• W2096871000 countsByYear W20968710002021 @default.
• W2096871000 countsByYear W20968710002022 @default.
• W2096871000 countsByYear W20968710002023 @default.
• W2096871000 crossrefType "journal-article" @default.
• W2096871000 hasAuthorship W2096871000A5031763103 @default.
• W2096871000 hasAuthorship W2096871000A5049307189 @default.
• W2096871000 hasAuthorship W2096871000A5065468510 @default.
• W2096871000 hasAuthorship W2096871000A5070399179 @default.
• W2096871000 hasBestOaLocation W20968710001 @default.
• W2096871000 hasConcept C126322002 @default.
• W2096871000 hasConcept C156957248 @default.
• W2096871000 hasConcept C2426938 @default.
• W2096871000 hasConcept C2776409635 @default.
• W2096871000 hasConcept C2776637226 @default.
• W2096871000 hasConcept C2776962512 @default.
• W2096871000 hasConcept C2777514703 @default.
• W2096871000 hasConcept C2778836808 @default.
• W2096871000 hasConcept C2781276175 @default.
• W2096871000 hasConcept C2908647359 @default.
• W2096871000 hasConcept C44249647 @default.
• W2096871000 hasConcept C501593827 @default.
• W2096871000 hasConcept C71924100 @default.
• W2096871000 hasConcept C86803240 @default.
• W2096871000 hasConcept C89423630 @default.
• W2096871000 hasConcept C98274493 @default.
• W2096871000 hasConcept C99454951 @default.
• W2096871000 hasConceptScore W2096871000C126322002 @default.
• W2096871000 hasConceptScore W2096871000C156957248 @default.
• W2096871000 hasConceptScore W2096871000C2426938 @default.
• W2096871000 hasConceptScore W2096871000C2776409635 @default.
• W2096871000 hasConceptScore W2096871000C2776637226 @default.
• W2096871000 hasConceptScore W2096871000C2776962512 @default.
• W2096871000 hasConceptScore W2096871000C2777514703 @default.
• W2096871000 hasConceptScore W2096871000C2778836808 @default.
• W2096871000 hasConceptScore W2096871000C2781276175 @default.
• W2096871000 hasConceptScore W2096871000C2908647359 @default.
• W2096871000 hasConceptScore W2096871000C44249647 @default.
• W2096871000 hasConceptScore W2096871000C501593827 @default.
• W2096871000 hasConceptScore W2096871000C71924100 @default.
• W2096871000 hasConceptScore W2096871000C86803240 @default.
• W2096871000 hasConceptScore W2096871000C89423630 @default.
• W2096871000 hasConceptScore W2096871000C98274493 @default.
• W2096871000 hasConceptScore W2096871000C99454951 @default.
• W2096871000 hasIssue "14" @default.
• W2096871000 hasLocation W20968710001 @default.
• W2096871000 hasLocation W20968710002 @default.
• W2096871000 hasLocation W20968710003 @default.
• W2096871000 hasLocation W20968710004 @default.
• W2096871000 hasOpenAccess W2096871000 @default.
• W2096871000 hasPrimaryLocation W20968710001 @default.
• W2096871000 hasRelatedWork W1973586260 @default.
• W2096871000 hasRelatedWork W2001870329 @default.
• W2096871000 hasRelatedWork W2105465792 @default.

• next