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• W2096876996 abstract "To evaluate the efficacy and the safety of repeated botulinum toxin type A (BT-A) injections in patients with severe acquired brain injury (ABI) and to gain a better knowledge of possible clinical or demographic characteristics associated with a better rehabilitation outcome.Prospective study with a 1-year follow-up period.Twenty-one patients with spasticity due to severe ABI and no further improving with rehabilitation treatment and oral anti-spastic drugs.Repeated BT-A injections associated to a rehabilitation programme.Barthel Index (BI), Modified Ashworth Score (MAS) and VAS score for pain subjective perception were recorded.At the end of the follow-up study, MAS, BI and VAS significantly improved. Despite the number of BT-A injections, a shorter interval between severe ABI onset and first BT-A treatment correlated to a better BI improvement. None of the patients experienced adverse events attributable to BT-A.BT-A was effective and safe in the treatment of spasticity in severe ABI patients, with a better functional outcome in those subjects treated earlier after spasticity onset. The lack of correlation between clinical outcome and number of injections suggests, in addition to a direct inhibition at the neuromuscular junction, a more distant BT-A long-term effect." @default.
• W2096876996 created "2016-06-24" @default.
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• W2096876996 date "2012-05-09" @default.
• W2096876996 modified "2023-10-17" @default.
• W2096876996 title "Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: A 1-year follow-up prospective study" @default.
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• W2096876996 doi "https://doi.org/10.3109/02699052.2012.660512" @default.
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