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- W2096890891 abstract "Abstract Genes controlling immunopathologic diseases of differing etiopathology may also influence susceptibility to autoimmune disease. B10.D1-H2q/SgJ mice with a 2538 G→A missense mutation in the tyrosine kinase-2 gene (Tyk2) are susceptible to Toxoplasma gondii yet resistant to autoimmune arthritis, unlike the wild-type B10.Q/Ai substrain. To understand whether Tyk2 is also important in a second autoimmune model, experimental allergic encephalomyelitis (EAE) was induced in B10.D1-H2q/SgJ (Tyk2A) and B10.Q/Ai (Tyk2G) mice with the myelin oligodendrocyte glycoprotein peptide 79–96. B10.D1-H2q/SgJ mice were resistant to EAE whereas B10.Q/Ai mice were susceptible, and a single copy of the Tyk2G allele conferred EAE susceptibility in F1 hybrids. Furthermore, EAE resistance in B10.D1-H2q/SgJ mice was overridden when pertussis toxin (PTX) was used to mimic the effects of environmental factors derived from infectious agents. Numerous cytokines and chemokines were increased when PTX was included in the immunization protocol. However, only RANTES, IL-6, and IFN-γ increased significantly with both genetic compensation and PTX treatment. These data indicate that Tyk2 is a shared autoimmune disease susceptibility gene whose genetic contribution to disease susceptibility can be modified by environmental factors. Single nucleotide polymorphisms like the one that distinguishes Tyk2 alleles are of considerable significance given the potential role of gene-by-environment interactions in autoimmune disease susceptibility." @default.
- W2096890891 created "2016-06-24" @default.
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- W2096890891 date "2009-06-15" @default.
- W2096890891 modified "2023-10-16" @default.
- W2096890891 title "A Single Nucleotide Polymorphism in <i>Tyk2</i> Controls Susceptibility to Experimental Allergic Encephalomyelitis" @default.
- W2096890891 cites W1496007453 @default.
- W2096890891 cites W1499527462 @default.
- W2096890891 cites W1596695343 @default.
- W2096890891 cites W1830814020 @default.
- W2096890891 cites W1847326477 @default.
- W2096890891 cites W1867019379 @default.
- W2096890891 cites W1877895673 @default.
- W2096890891 cites W1916954038 @default.
- W2096890891 cites W1921550679 @default.
- W2096890891 cites W1923296204 @default.
- W2096890891 cites W1955200347 @default.
- W2096890891 cites W1963879942 @default.
- W2096890891 cites W1968649229 @default.
- W2096890891 cites W1974706235 @default.
- W2096890891 cites W1981775064 @default.
- W2096890891 cites W1982657393 @default.
- W2096890891 cites W1983180340 @default.
- W2096890891 cites W1984342091 @default.
- W2096890891 cites W1998436005 @default.
- W2096890891 cites W2001981959 @default.
- W2096890891 cites W2006249161 @default.
- W2096890891 cites W2015479125 @default.
- W2096890891 cites W2015593444 @default.
- W2096890891 cites W2025594403 @default.
- W2096890891 cites W2028925585 @default.
- W2096890891 cites W2034607409 @default.
- W2096890891 cites W2036449838 @default.
- W2096890891 cites W2038451848 @default.
- W2096890891 cites W2039709829 @default.
- W2096890891 cites W2042960115 @default.
- W2096890891 cites W2046579578 @default.
- W2096890891 cites W2046784038 @default.
- W2096890891 cites W2046817896 @default.
- W2096890891 cites W2052392685 @default.
- W2096890891 cites W2057172275 @default.
- W2096890891 cites W2061694840 @default.
- W2096890891 cites W2066890136 @default.
- W2096890891 cites W2075283457 @default.
- W2096890891 cites W2075997332 @default.
- W2096890891 cites W2076889715 @default.
- W2096890891 cites W2079865485 @default.
- W2096890891 cites W2082062343 @default.
- W2096890891 cites W2087144342 @default.
- W2096890891 cites W2091390560 @default.
- W2096890891 cites W2093294507 @default.
- W2096890891 cites W2093953283 @default.
- W2096890891 cites W2094111001 @default.
- W2096890891 cites W2099579812 @default.
- W2096890891 cites W2101059261 @default.
- W2096890891 cites W2102140340 @default.
- W2096890891 cites W2106100082 @default.
- W2096890891 cites W2109574134 @default.
- W2096890891 cites W2110459793 @default.
- W2096890891 cites W2111085423 @default.
- W2096890891 cites W2112449510 @default.
- W2096890891 cites W2116641130 @default.
- W2096890891 cites W2120388891 @default.
- W2096890891 cites W2123522612 @default.
- W2096890891 cites W2125797445 @default.
- W2096890891 cites W2126574528 @default.
- W2096890891 cites W2127818820 @default.
- W2096890891 cites W2131666890 @default.
- W2096890891 cites W2132499228 @default.
- W2096890891 cites W2133026403 @default.
- W2096890891 cites W2133489776 @default.
- W2096890891 cites W2135424108 @default.
- W2096890891 cites W2136371196 @default.
- W2096890891 cites W2147787161 @default.
- W2096890891 cites W2155048481 @default.
- W2096890891 cites W2155855461 @default.
- W2096890891 cites W2157815997 @default.
- W2096890891 cites W2161550125 @default.
- W2096890891 cites W2166787544 @default.
- W2096890891 cites W2552733521 @default.
- W2096890891 cites W3212392330 @default.
- W2096890891 doi "https://doi.org/10.4049/jimmunol.0900142" @default.
- W2096890891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3008628" @default.
- W2096890891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19494301" @default.
- W2096890891 hasPublicationYear "2009" @default.
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