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• W2096926873 abstract "Inflammation is increasingly recognised in pulmonary arterial hypertension (PAH). Given that dexamethasone (dex) reverses PAH and pulmonary vascular remodelling in established rat monocrotaline (MCT)-induced PAH, we tested contributing mechanisms in pulmonary arterial smooth muscle cells (PASMC). Nuclear localisation of the p65 subunit of NF-κB was used as a marker of inflammation in MCT-exposed rats. Methods: PASMC from control and MCT 6-week old male Wistar rats were treated with increasing dex concentrations. Proliferation (3H-thymidine) and apoptosis (Hoechst nuclear staining; DNA fragmentation ELISA) assays were performed (n=5 per group). Immunohistochemistry for caspase 3 and p65 was performed on paraffin-embedded lungs from day 28 MCT-alone, MCT+dex-treated and control rats. Results: Dex reduced proliferation of PASMC at all concentrations with a maximal effect seen at 10-7M (3H-thymidine counts/minute 84997±6802 to 1993±3135, p Conclusion: Dexamethasone reduces proliferation and augments apoptosis in rat PASMC in vitro, and reduces activation of NF-κB within vascular cells. These actions, at least in part, may explain the reversal of PAH by dex seen in the rat MCT-PAH model." @default.
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• W2096926873 date "2012-09-01" @default.
• W2096926873 modified "2023-09-27" @default.
• W2096926873 title "Dexamethasone induces anti-remodelling effects in rat pulmonary arterial smooth muscle cells" @default.
• W2096926873 hasPublicationYear "2012" @default.
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