Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096933572> ?p ?o ?g. }
- W2096933572 endingPage "322" @default.
- W2096933572 startingPage "316" @default.
- W2096933572 abstract "Background Invasive aspergillosis (IA) is a major cause of morbidity and mortality in immunocompromised children. We investigated the usefulness of an Aspergillus galactomannan (GM) antigen assay as a diagnostic tool for IA in pediatric cancer patients and hematopoietic cell transplantation (HCT) recipients. Procedure The GM antigen assay results were analyzed in 749 blood samples from 99 patients. A GM index (GMI) greater than or equal to 0.5 on at least two separate occasions was considered positive. A review of the clinical data was performed for subjects with proven or probable IA. Results Twenty-one of 23 patients with proven or probable IA had positive GM antigen test results (91.3% sensitivity, 95% CI 71.9–98.9; 81.7% specificity, 95% CI 69.6–90.5; P < 0.0001). The false-positive rate was 18.3%. Being younger than 3 years of age, having a solid tumor, and receiving HCT within 4 weeks of the test were statistically significant factors for causing false-positive results (P < 0.05). Among the 23 patients with IA (six proven, 17 probable), 16 (69.6%) had hematological malignancies, five (22.7%) had solid tumors, and two (8.7%) had primary immunodeficiency. Nineteen patients (82.6%) received HCT. The most common clinical site of IA was the lungs (91.3%), and consolidation was the most frequent finding in chest CT scans (36.8%). The mortality at 12 weeks was 43.5%. Conclusions Having a positive GM assay at least twice is useful in diagnosing IA in pediatric patients with cancer and HCT recipients. Pediatr Blood Cancer 2013;60:316–322. © 2012 Wiley Periodicals, Inc." @default.
- W2096933572 created "2016-06-24" @default.
- W2096933572 creator A5032744537 @default.
- W2096933572 creator A5038682278 @default.
- W2096933572 creator A5065602761 @default.
- W2096933572 creator A5068266757 @default.
- W2096933572 creator A5077133696 @default.
- W2096933572 creator A5082079750 @default.
- W2096933572 creator A5085504469 @default.
- W2096933572 creator A5089505849 @default.
- W2096933572 creator A5089641474 @default.
- W2096933572 date "2012-10-05" @default.
- W2096933572 modified "2023-10-16" @default.
- W2096933572 title "<i>Aspergillus</i>galactomannan antigen assay and invasive aspergillosis in pediatric cancer patients and hematopoietic stem cell transplant recipients" @default.
- W2096933572 cites W160107827 @default.
- W2096933572 cites W1643501947 @default.
- W2096933572 cites W1894066987 @default.
- W2096933572 cites W1964565115 @default.
- W2096933572 cites W1972022476 @default.
- W2096933572 cites W1974497314 @default.
- W2096933572 cites W1982478538 @default.
- W2096933572 cites W1985985205 @default.
- W2096933572 cites W1987061081 @default.
- W2096933572 cites W1996999247 @default.
- W2096933572 cites W2007123701 @default.
- W2096933572 cites W2018670298 @default.
- W2096933572 cites W2021238142 @default.
- W2096933572 cites W2034556188 @default.
- W2096933572 cites W2045464383 @default.
- W2096933572 cites W2046383292 @default.
- W2096933572 cites W2066973259 @default.
- W2096933572 cites W2072794245 @default.
- W2096933572 cites W2073746974 @default.
- W2096933572 cites W2075702007 @default.
- W2096933572 cites W2076552225 @default.
- W2096933572 cites W2076920097 @default.
- W2096933572 cites W2095575381 @default.
- W2096933572 cites W2112391917 @default.
- W2096933572 cites W2118095577 @default.
- W2096933572 cites W2128039798 @default.
- W2096933572 cites W2135329522 @default.
- W2096933572 cites W2139639241 @default.
- W2096933572 cites W2142482664 @default.
- W2096933572 cites W2144686332 @default.
- W2096933572 cites W2147217394 @default.
- W2096933572 cites W2148051102 @default.
- W2096933572 cites W2148580834 @default.
- W2096933572 cites W2151082945 @default.
- W2096933572 cites W2152260754 @default.
- W2096933572 cites W2156708464 @default.
- W2096933572 cites W2156924221 @default.
- W2096933572 cites W2160509772 @default.
- W2096933572 cites W2164049808 @default.
- W2096933572 cites W2166734004 @default.
- W2096933572 doi "https://doi.org/10.1002/pbc.24363" @default.
- W2096933572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23042761" @default.
- W2096933572 hasPublicationYear "2012" @default.
- W2096933572 type Work @default.
- W2096933572 sameAs 2096933572 @default.
- W2096933572 citedByCount "38" @default.
- W2096933572 countsByYear W20969335722014 @default.
- W2096933572 countsByYear W20969335722015 @default.
- W2096933572 countsByYear W20969335722016 @default.
- W2096933572 countsByYear W20969335722017 @default.
- W2096933572 countsByYear W20969335722018 @default.
- W2096933572 countsByYear W20969335722019 @default.
- W2096933572 countsByYear W20969335722021 @default.
- W2096933572 countsByYear W20969335722023 @default.
- W2096933572 crossrefType "journal-article" @default.
- W2096933572 hasAuthorship W2096933572A5032744537 @default.
- W2096933572 hasAuthorship W2096933572A5038682278 @default.
- W2096933572 hasAuthorship W2096933572A5065602761 @default.
- W2096933572 hasAuthorship W2096933572A5068266757 @default.
- W2096933572 hasAuthorship W2096933572A5077133696 @default.
- W2096933572 hasAuthorship W2096933572A5082079750 @default.
- W2096933572 hasAuthorship W2096933572A5085504469 @default.
- W2096933572 hasAuthorship W2096933572A5089505849 @default.
- W2096933572 hasAuthorship W2096933572A5089641474 @default.
- W2096933572 hasConcept C121608353 @default.
- W2096933572 hasConcept C126322002 @default.
- W2096933572 hasConcept C147483822 @default.
- W2096933572 hasConcept C203014093 @default.
- W2096933572 hasConcept C2776391196 @default.
- W2096933572 hasConcept C2777408962 @default.
- W2096933572 hasConcept C2779175654 @default.
- W2096933572 hasConcept C2780782397 @default.
- W2096933572 hasConcept C2911091166 @default.
- W2096933572 hasConcept C2993561819 @default.
- W2096933572 hasConcept C59822182 @default.
- W2096933572 hasConcept C71924100 @default.
- W2096933572 hasConcept C86803240 @default.
- W2096933572 hasConcept C90924648 @default.
- W2096933572 hasConceptScore W2096933572C121608353 @default.
- W2096933572 hasConceptScore W2096933572C126322002 @default.
- W2096933572 hasConceptScore W2096933572C147483822 @default.
- W2096933572 hasConceptScore W2096933572C203014093 @default.
- W2096933572 hasConceptScore W2096933572C2776391196 @default.
- W2096933572 hasConceptScore W2096933572C2777408962 @default.