Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096949620> ?p ?o ?g. }
- W2096949620 endingPage "1192" @default.
- W2096949620 startingPage "1183" @default.
- W2096949620 abstract "Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor. Unifying mechanisms have been implicated in the pathogenesis of polyQ-dependent neurodegenerative diseases including SBMA, Huntington disease and spinocerebellar ataxias. It has been suggested that mutant protein containing polyQ inhibits histone acetyltransferase activity, resulting in transcriptional dysfunction and subsequent neuronal dysfunction. Histone deacetylase (HDAC) inhibitors alleviate neurological phenotypes in fly and mouse models of polyQ disease, although the therapeutic effect is limited by the toxicity of these compounds. We studied the therapeutic effects of sodium butyrate (SB), an HDAC inhibitor, in a transgenic mouse model of SBMA. Oral administration of SB ameliorated neurological phenotypes as well as increased acetylation of nuclear histone in neural tissues. These therapeutic effects, however, were seen only within a narrow range of SB dosage. Our results indicate that SB is a possible therapeutic agent for SBMA and other polyQ diseases, although an appropriate dose should be determined for clinical application." @default.
- W2096949620 created "2016-06-24" @default.
- W2096949620 creator A5031930678 @default.
- W2096949620 creator A5035544844 @default.
- W2096949620 creator A5036681718 @default.
- W2096949620 creator A5039543515 @default.
- W2096949620 creator A5045535997 @default.
- W2096949620 creator A5048034742 @default.
- W2096949620 creator A5050964668 @default.
- W2096949620 creator A5063473594 @default.
- W2096949620 creator A5082980895 @default.
- W2096949620 creator A5089575538 @default.
- W2096949620 date "2004-04-21" @default.
- W2096949620 modified "2023-10-16" @default.
- W2096949620 title "Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy" @default.
- W2096949620 cites W1578515047 @default.
- W2096949620 cites W1643390591 @default.
- W2096949620 cites W1780809832 @default.
- W2096949620 cites W1812576394 @default.
- W2096949620 cites W1964372470 @default.
- W2096949620 cites W1966489527 @default.
- W2096949620 cites W1972771185 @default.
- W2096949620 cites W1973716706 @default.
- W2096949620 cites W1974477415 @default.
- W2096949620 cites W1976967609 @default.
- W2096949620 cites W1977383752 @default.
- W2096949620 cites W1977733590 @default.
- W2096949620 cites W1980799794 @default.
- W2096949620 cites W1985902870 @default.
- W2096949620 cites W1986422550 @default.
- W2096949620 cites W1986461863 @default.
- W2096949620 cites W1988081634 @default.
- W2096949620 cites W1989129533 @default.
- W2096949620 cites W1998982625 @default.
- W2096949620 cites W2002431899 @default.
- W2096949620 cites W2006101507 @default.
- W2096949620 cites W2013452556 @default.
- W2096949620 cites W2017228656 @default.
- W2096949620 cites W2034997979 @default.
- W2096949620 cites W2043888873 @default.
- W2096949620 cites W2048162805 @default.
- W2096949620 cites W2060148506 @default.
- W2096949620 cites W2060750433 @default.
- W2096949620 cites W2078784691 @default.
- W2096949620 cites W2091681614 @default.
- W2096949620 cites W2099685145 @default.
- W2096949620 cites W2101481997 @default.
- W2096949620 cites W2105180380 @default.
- W2096949620 cites W2111714299 @default.
- W2096949620 cites W2113333419 @default.
- W2096949620 cites W2113998330 @default.
- W2096949620 cites W2117862287 @default.
- W2096949620 cites W2121506107 @default.
- W2096949620 cites W2122440289 @default.
- W2096949620 cites W2122631256 @default.
- W2096949620 cites W2131472300 @default.
- W2096949620 cites W2136364567 @default.
- W2096949620 cites W2139548932 @default.
- W2096949620 cites W2140795771 @default.
- W2096949620 cites W2148688106 @default.
- W2096949620 cites W2154445158 @default.
- W2096949620 cites W2154528582 @default.
- W2096949620 cites W2159317313 @default.
- W2096949620 cites W2170125790 @default.
- W2096949620 cites W2249338989 @default.
- W2096949620 cites W2362145165 @default.
- W2096949620 cites W89892064 @default.
- W2096949620 doi "https://doi.org/10.1093/hmg/ddh131" @default.
- W2096949620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15102712" @default.
- W2096949620 hasPublicationYear "2004" @default.
- W2096949620 type Work @default.
- W2096949620 sameAs 2096949620 @default.
- W2096949620 citedByCount "242" @default.
- W2096949620 countsByYear W20969496202012 @default.
- W2096949620 countsByYear W20969496202013 @default.
- W2096949620 countsByYear W20969496202014 @default.
- W2096949620 countsByYear W20969496202015 @default.
- W2096949620 countsByYear W20969496202016 @default.
- W2096949620 countsByYear W20969496202017 @default.
- W2096949620 countsByYear W20969496202018 @default.
- W2096949620 countsByYear W20969496202019 @default.
- W2096949620 countsByYear W20969496202020 @default.
- W2096949620 countsByYear W20969496202021 @default.
- W2096949620 countsByYear W20969496202022 @default.
- W2096949620 countsByYear W20969496202023 @default.
- W2096949620 crossrefType "journal-article" @default.
- W2096949620 hasAuthorship W2096949620A5031930678 @default.
- W2096949620 hasAuthorship W2096949620A5035544844 @default.
- W2096949620 hasAuthorship W2096949620A5036681718 @default.
- W2096949620 hasAuthorship W2096949620A5039543515 @default.
- W2096949620 hasAuthorship W2096949620A5045535997 @default.
- W2096949620 hasAuthorship W2096949620A5048034742 @default.
- W2096949620 hasAuthorship W2096949620A5050964668 @default.
- W2096949620 hasAuthorship W2096949620A5063473594 @default.
- W2096949620 hasAuthorship W2096949620A5082980895 @default.
- W2096949620 hasAuthorship W2096949620A5089575538 @default.
- W2096949620 hasBestOaLocation W20969496201 @default.
- W2096949620 hasConcept C102230213 @default.