Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096965934> ?p ?o ?g. }
- W2096965934 endingPage "329" @default.
- W2096965934 startingPage "322" @default.
- W2096965934 abstract "Soft tissue sarcomas (STS) are rare tumors with mesenchymal origin, accounting for 1% of all human cancer. Local control of STS can be obtained through the use of surgery and radiotherapy. In about 40% of these patients, disease will recur at distant sites, and of these more than 90% will die because of this aggressive malignancy. In advanced and/or metastatic STS patients treated with anthracycline-based regimen the median overall survival is about 12 months, and it has remained unchanged during the last 20 years. Clearly, this strongly suggests the need for discover more active compounds in STS, such as imatinib in GIST or dermatofibrosarcoma patients. In this paper we describe the crucial role of angiogenesis mechanisms in sarcomas development and progression. Consequentially, we focus on pazopanib, a novel multitargeted tyrosine kinase inhibitor with anti-angiogenic activity, mainly due to VEGFR2 pathway interference. We also analyze principal completed trials leading pazopanib approval in sarcomas pretreated patients." @default.
- W2096965934 created "2016-06-24" @default.
- W2096965934 creator A5007548728 @default.
- W2096965934 creator A5014894893 @default.
- W2096965934 creator A5043414478 @default.
- W2096965934 creator A5049665672 @default.
- W2096965934 creator A5049966462 @default.
- W2096965934 creator A5052612647 @default.
- W2096965934 creator A5062612530 @default.
- W2096965934 creator A5068449166 @default.
- W2096965934 creator A5078959397 @default.
- W2096965934 creator A5080322861 @default.
- W2096965934 date "2014-02-01" @default.
- W2096965934 modified "2023-09-23" @default.
- W2096965934 title "Pazopanib a tyrosine kinase inhibitor with strong anti-angiogenetic activity: A new treatment for metastatic soft tissue sarcoma" @default.
- W2096965934 cites W150885687 @default.
- W2096965934 cites W1603286011 @default.
- W2096965934 cites W1973840148 @default.
- W2096965934 cites W1974228208 @default.
- W2096965934 cites W1976990367 @default.
- W2096965934 cites W1987454669 @default.
- W2096965934 cites W2001837200 @default.
- W2096965934 cites W2006055086 @default.
- W2096965934 cites W2039559785 @default.
- W2096965934 cites W2043269756 @default.
- W2096965934 cites W2054956339 @default.
- W2096965934 cites W2054979979 @default.
- W2096965934 cites W2057195209 @default.
- W2096965934 cites W2063605511 @default.
- W2096965934 cites W2064254592 @default.
- W2096965934 cites W2068923084 @default.
- W2096965934 cites W2071138269 @default.
- W2096965934 cites W2072928113 @default.
- W2096965934 cites W2082209487 @default.
- W2096965934 cites W2089403275 @default.
- W2096965934 cites W2091076857 @default.
- W2096965934 cites W2095771928 @default.
- W2096965934 cites W2096902150 @default.
- W2096965934 cites W2099022883 @default.
- W2096965934 cites W2101776780 @default.
- W2096965934 cites W2107230638 @default.
- W2096965934 cites W2109606826 @default.
- W2096965934 cites W2112756547 @default.
- W2096965934 cites W2127447993 @default.
- W2096965934 cites W2131798870 @default.
- W2096965934 cites W2160888189 @default.
- W2096965934 cites W2162424705 @default.
- W2096965934 cites W2167039827 @default.
- W2096965934 cites W2414707555 @default.
- W2096965934 cites W2551773592 @default.
- W2096965934 cites W31979510 @default.
- W2096965934 cites W4211207176 @default.
- W2096965934 cites W4245635197 @default.
- W2096965934 cites W4247618793 @default.
- W2096965934 cites W4384816539 @default.
- W2096965934 doi "https://doi.org/10.1016/j.critrevonc.2013.08.012" @default.
- W2096965934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24041629" @default.
- W2096965934 hasPublicationYear "2014" @default.
- W2096965934 type Work @default.
- W2096965934 sameAs 2096965934 @default.
- W2096965934 citedByCount "55" @default.
- W2096965934 countsByYear W20969659342014 @default.
- W2096965934 countsByYear W20969659342015 @default.
- W2096965934 countsByYear W20969659342016 @default.
- W2096965934 countsByYear W20969659342017 @default.
- W2096965934 countsByYear W20969659342018 @default.
- W2096965934 countsByYear W20969659342019 @default.
- W2096965934 countsByYear W20969659342020 @default.
- W2096965934 countsByYear W20969659342021 @default.
- W2096965934 countsByYear W20969659342022 @default.
- W2096965934 countsByYear W20969659342023 @default.
- W2096965934 crossrefType "journal-article" @default.
- W2096965934 hasAuthorship W2096965934A5007548728 @default.
- W2096965934 hasAuthorship W2096965934A5014894893 @default.
- W2096965934 hasAuthorship W2096965934A5043414478 @default.
- W2096965934 hasAuthorship W2096965934A5049665672 @default.
- W2096965934 hasAuthorship W2096965934A5049966462 @default.
- W2096965934 hasAuthorship W2096965934A5052612647 @default.
- W2096965934 hasAuthorship W2096965934A5062612530 @default.
- W2096965934 hasAuthorship W2096965934A5068449166 @default.
- W2096965934 hasAuthorship W2096965934A5078959397 @default.
- W2096965934 hasAuthorship W2096965934A5080322861 @default.
- W2096965934 hasConcept C121608353 @default.
- W2096965934 hasConcept C126322002 @default.
- W2096965934 hasConcept C136948725 @default.
- W2096965934 hasConcept C142724271 @default.
- W2096965934 hasConcept C143998085 @default.
- W2096965934 hasConcept C16930146 @default.
- W2096965934 hasConcept C170493617 @default.
- W2096965934 hasConcept C2775922572 @default.
- W2096965934 hasConcept C2776056115 @default.
- W2096965934 hasConcept C2777583451 @default.
- W2096965934 hasConcept C2778256501 @default.
- W2096965934 hasConcept C2778439243 @default.
- W2096965934 hasConcept C2778464197 @default.
- W2096965934 hasConcept C2778629024 @default.
- W2096965934 hasConcept C2778729363 @default.
- W2096965934 hasConcept C2778820342 @default.