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• W2096971694 abstract "Background: Recently, arsenic trioxide has increasingly been used for relapsed acute promyelocytic leukemia. However, it is known to have several adverse effects, including acute cardiac toxicities. Objective: To determine cardiac toxicities resulting from arsenic trioxide therapy in patients with relapsed or refractory acute promyelocytic leukemia. Design: Phase II clinical prospective cohort study. Setting: A university hospital in Hamamatsu, Japan. Patients: 8 patients with relapsed acute promyelocytic leukemia. Intervention: Arsenic trioxide, 0.15 mg/kg of body weight, administered daily by 2-hour infusion for a maximum of 60 days. Measurements: Continuous monitoring with ambulatory electrocardiography. Results: Five patients (63%) achieved complete remission. During induction therapy with arsenic trioxide, prolonged QT intervals were observed in all patients. Ventricular premature contractions were noticed during 8 of 12 courses of therapy. Four patients developed nonsustained ventricular tachycardia and required treatment with antiarrhythmic agents. Conclusions: Cardiac toxicity occurs during arsenic trioxide therapy in patients with acute promyelocytic leukemia. Such patients should be monitored for prolonged QT intervals and ventricular arrhythmia." @default.
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• W2096971694 date "2000-12-05" @default.
• W2096971694 modified "2023-10-15" @default.
• W2096971694 title "Prolongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic Leukemia" @default.
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• W2096971694 doi "https://doi.org/10.7326/0003-4819-133-11-200012050-00012" @default.
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