FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096973149> ?p ?o ?g. }

• W2096973149 endingPage "60" @default.
• W2096973149 startingPage "53" @default.
• W2096973149 abstract "Although the past 30 years have seen remarkable progress in the treatment of childhood malignancies, not all types of cancer have enjoyed this improvement in prognosis. Because of this, clinical trials are ongoing in which novel treatment approaches are being evaluated, including immunotherapy, radionuclide therapy, and the use of agents that induce tumor apoptosis or differentiation. Additional treatment strategies are needed, however. One such strategy involves the use of angiogenesis inhibitors. Angiogenesis is the biologic process of new blood vessel formation. In addition to occurring as part of several normal, physiologic processes, angiogenesis is an essential component of a number of pathologic conditions, including cancer. Compelling data suggest that inhibition of angiogenesis can not only prevent tumor-associated neovascularization but also affect tumor growth and spread. An anticancer approach in which the tumor-induced new blood vessels are targeted is particularly appealing for several reasons. First, despite the extreme molecular and phenotypic heterogeneity of human cancer, it is likely that most, if not all, tumor types require neovascularization to achieve their full malignant phenotype. Therefore, antiangiogenic therapy may have broad applicability for the treatment of human cancer, as well as the many other pathologic processes that depend on angiogenesis. Second, the endothelial cells, although rapidly proliferating, are inherently normal with a very low rate of mutation. They are, therefore, unlikely to evolve an angiogenesis inhibitor-insensitive phenotype. This is in distinction to the rapidly proliferating tumor cells that do undergo a high rate of spontaneous mutation and therefore can readily generate drug-resistant clones. This review discusses progress in the development of antiangiogenic therapy for the treatment of pediatric solid tumors." @default.
• W2096973149 created "2016-06-24" @default.
• W2096973149 creator A5063456712 @default.
• W2096973149 creator A5078860285 @default.
• W2096973149 date "2004-02-01" @default.
• W2096973149 modified "2023-09-23" @default.
• W2096973149 title "Antiangiogenic therapy for the treatment of pediatric solid malignancies" @default.
• W2096973149 cites W1265988497 @default.
• W2096973149 cites W1561059299 @default.
• W2096973149 cites W1573363574 @default.
• W2096973149 cites W1794577973 @default.
• W2096973149 cites W1874909451 @default.
• W2096973149 cites W1941829554 @default.
• W2096973149 cites W1969328947 @default.
• W2096973149 cites W1970246132 @default.
• W2096973149 cites W1979356442 @default.
• W2096973149 cites W1981486175 @default.
• W2096973149 cites W1993845012 @default.
• W2096973149 cites W1994695048 @default.
• W2096973149 cites W1996590176 @default.
• W2096973149 cites W2009240587 @default.
• W2096973149 cites W2012255417 @default.
• W2096973149 cites W2012852444 @default.
• W2096973149 cites W2026151657 @default.
• W2096973149 cites W2029883816 @default.
• W2096973149 cites W2033791403 @default.
• W2096973149 cites W2042419096 @default.
• W2096973149 cites W2048079618 @default.
• W2096973149 cites W2051379819 @default.
• W2096973149 cites W2051763059 @default.
• W2096973149 cites W2055153063 @default.
• W2096973149 cites W2056057979 @default.
• W2096973149 cites W2056591005 @default.
• W2096973149 cites W2060285807 @default.
• W2096973149 cites W2065447462 @default.
• W2096973149 cites W2068910710 @default.
• W2096973149 cites W2072928113 @default.
• W2096973149 cites W2085048249 @default.
• W2096973149 cites W2087220149 @default.
• W2096973149 cites W2088257209 @default.
• W2096973149 cites W2088726343 @default.
• W2096973149 cites W2090401954 @default.
• W2096973149 cites W2092104690 @default.
• W2096973149 cites W2094618776 @default.
• W2096973149 cites W2094794021 @default.
• W2096973149 cites W2113813607 @default.
• W2096973149 cites W2131798870 @default.
• W2096973149 cites W2135984915 @default.
• W2096973149 cites W2141836567 @default.
• W2096973149 cites W2142786915 @default.
• W2096973149 cites W2145639716 @default.
• W2096973149 cites W2152215024 @default.
• W2096973149 cites W2154061285 @default.
• W2096973149 cites W2156367667 @default.
• W2096973149 cites W232361230 @default.
• W2096973149 cites W2340893063 @default.
• W2096973149 cites W4248515563 @default.
• W2096973149 doi "https://doi.org/10.1053/j.sempedsurg.2003.09.008" @default.
• W2096973149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14765371" @default.
• W2096973149 hasPublicationYear "2004" @default.
• W2096973149 type Work @default.
• W2096973149 sameAs 2096973149 @default.
• W2096973149 citedByCount "11" @default.
• W2096973149 countsByYear W20969731492012 @default.
• W2096973149 countsByYear W20969731492013 @default.
• W2096973149 countsByYear W20969731492016 @default.
• W2096973149 countsByYear W20969731492023 @default.
• W2096973149 crossrefType "journal-article" @default.
• W2096973149 hasAuthorship W2096973149A5063456712 @default.
• W2096973149 hasAuthorship W2096973149A5078860285 @default.
• W2096973149 hasConcept C121608353 @default.
• W2096973149 hasConcept C126322002 @default.
• W2096973149 hasConcept C203014093 @default.
• W2096973149 hasConcept C2777701055 @default.
• W2096973149 hasConcept C2778271429 @default.
• W2096973149 hasConcept C2780394083 @default.
• W2096973149 hasConcept C2781230642 @default.
• W2096973149 hasConcept C502942594 @default.
• W2096973149 hasConcept C71924100 @default.
• W2096973149 hasConceptScore W2096973149C121608353 @default.
• W2096973149 hasConceptScore W2096973149C126322002 @default.
• W2096973149 hasConceptScore W2096973149C203014093 @default.
• W2096973149 hasConceptScore W2096973149C2777701055 @default.
• W2096973149 hasConceptScore W2096973149C2778271429 @default.
• W2096973149 hasConceptScore W2096973149C2780394083 @default.
• W2096973149 hasConceptScore W2096973149C2781230642 @default.
• W2096973149 hasConceptScore W2096973149C502942594 @default.
• W2096973149 hasConceptScore W2096973149C71924100 @default.
• W2096973149 hasIssue "1" @default.
• W2096973149 hasLocation W20969731491 @default.
• W2096973149 hasLocation W20969731492 @default.
• W2096973149 hasOpenAccess W2096973149 @default.
• W2096973149 hasPrimaryLocation W20969731491 @default.
• W2096973149 hasRelatedWork W1498380447 @default.
• W2096973149 hasRelatedWork W1600879783 @default.
• W2096973149 hasRelatedWork W1980070021 @default.
• W2096973149 hasRelatedWork W2073359472 @default.
• W2096973149 hasRelatedWork W2102140960 @default.

• next