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• W2096984734 abstract "The six MCM (minichromosome maintenance) proteins are essential DNA replication factors that each contain a putative ATP binding motif and together form a heterohexameric complex. We show that these motifs are required for viability in vivo and coordinated ATP hydrolysis in vitro. Mutational analysis discriminates between two functionally distinct MCM protein subgroups: Mcm4p, 6p, and 7p contribute canonical ATP binding motifs essential for catalysis, whereas the related motifs in Mcm2p, 3p, and 5p serve a regulatory function. Reconstitution experiments indicate that specific functional interactions between these two subgroups are required for robust ATP hydrolysis. Our observations show parallels between the MCM complex and the F1-ATPase, and we discuss how ATP hydrolysis by the MCM complex might be coupled to DNA strand separation." @default.
• W2096984734 created "2016-06-24" @default.
• W2096984734 creator A5023161002 @default.
• W2096984734 creator A5048445038 @default.
• W2096984734 date "2001-11-01" @default.
• W2096984734 modified "2023-10-14" @default.
• W2096984734 title "Interactions between Two Catalytically Distinct MCM Subgroups Are Essential for Coordinated ATP Hydrolysis and DNA Replication" @default.
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• W2096984734 doi "https://doi.org/10.1016/s1097-2765(01)00389-6" @default.
• W2096984734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11741544" @default.
• W2096984734 hasPublicationYear "2001" @default.
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