Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097030512> ?p ?o ?g. }
- W2097030512 endingPage "139" @default.
- W2097030512 startingPage "133" @default.
- W2097030512 abstract "Imatinib is a Bcr-Abl inhibitor used as first-line therapy of chronic myeloid leukemia (CML). p21(Cip1), initially described as a cell cycle inhibitor, also protects from apoptosis in some models. We describe that imatinib down-regulates p21(Cip1) expression in CML cells. Using K562 cells with inducible p21 expression and transient transfections we found that p21 confers partial resistance to imatinib-induced apoptosis. This protection is not related to the G2-arrest provoked by p21, a decrease in the imatinib activity against Bcr-Abl or a cytoplasmic localization of p21. The results suggest an involvement of p21(Cip1) in the response to imatinib in CML." @default.
- W2097030512 created "2016-06-24" @default.
- W2097030512 creator A5013847185 @default.
- W2097030512 creator A5013860928 @default.
- W2097030512 creator A5021164294 @default.
- W2097030512 creator A5036887524 @default.
- W2097030512 creator A5041769016 @default.
- W2097030512 creator A5069152067 @default.
- W2097030512 creator A5081502221 @default.
- W2097030512 creator A5081573140 @default.
- W2097030512 date "2010-06-01" @default.
- W2097030512 modified "2023-10-14" @default.
- W2097030512 title "p21Cip1 Confers resistance to imatinib in human chronic myeloid leukemia cells" @default.
- W2097030512 cites W1513007231 @default.
- W2097030512 cites W1577832196 @default.
- W2097030512 cites W1967865921 @default.
- W2097030512 cites W1969385456 @default.
- W2097030512 cites W1972305847 @default.
- W2097030512 cites W1977299280 @default.
- W2097030512 cites W1996926240 @default.
- W2097030512 cites W2000284333 @default.
- W2097030512 cites W2005942762 @default.
- W2097030512 cites W2013976267 @default.
- W2097030512 cites W2019600656 @default.
- W2097030512 cites W2031369019 @default.
- W2097030512 cites W2044057392 @default.
- W2097030512 cites W2058187662 @default.
- W2097030512 cites W2066848701 @default.
- W2097030512 cites W2067913005 @default.
- W2097030512 cites W2072088194 @default.
- W2097030512 cites W2088726624 @default.
- W2097030512 cites W2089218510 @default.
- W2097030512 cites W2089964771 @default.
- W2097030512 cites W2091735622 @default.
- W2097030512 cites W2092967525 @default.
- W2097030512 cites W2112953655 @default.
- W2097030512 cites W2118109822 @default.
- W2097030512 cites W2134594365 @default.
- W2097030512 cites W2136306650 @default.
- W2097030512 cites W2147242002 @default.
- W2097030512 cites W2158444028 @default.
- W2097030512 cites W2162262059 @default.
- W2097030512 cites W2162525969 @default.
- W2097030512 cites W2314938037 @default.
- W2097030512 cites W2317948309 @default.
- W2097030512 cites W2321645860 @default.
- W2097030512 cites W2325383363 @default.
- W2097030512 cites W2332129083 @default.
- W2097030512 cites W2399876335 @default.
- W2097030512 doi "https://doi.org/10.1016/j.canlet.2009.11.017" @default.
- W2097030512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20042273" @default.
- W2097030512 hasPublicationYear "2010" @default.
- W2097030512 type Work @default.
- W2097030512 sameAs 2097030512 @default.
- W2097030512 citedByCount "18" @default.
- W2097030512 countsByYear W20970305122012 @default.
- W2097030512 countsByYear W20970305122013 @default.
- W2097030512 countsByYear W20970305122014 @default.
- W2097030512 countsByYear W20970305122015 @default.
- W2097030512 countsByYear W20970305122016 @default.
- W2097030512 countsByYear W20970305122017 @default.
- W2097030512 countsByYear W20970305122018 @default.
- W2097030512 countsByYear W20970305122020 @default.
- W2097030512 countsByYear W20970305122022 @default.
- W2097030512 countsByYear W20970305122023 @default.
- W2097030512 crossrefType "journal-article" @default.
- W2097030512 hasAuthorship W2097030512A5013847185 @default.
- W2097030512 hasAuthorship W2097030512A5013860928 @default.
- W2097030512 hasAuthorship W2097030512A5021164294 @default.
- W2097030512 hasAuthorship W2097030512A5036887524 @default.
- W2097030512 hasAuthorship W2097030512A5041769016 @default.
- W2097030512 hasAuthorship W2097030512A5069152067 @default.
- W2097030512 hasAuthorship W2097030512A5081502221 @default.
- W2097030512 hasAuthorship W2097030512A5081573140 @default.
- W2097030512 hasBestOaLocation W20970305122 @default.
- W2097030512 hasConcept C125418893 @default.
- W2097030512 hasConcept C171122931 @default.
- W2097030512 hasConcept C190283241 @default.
- W2097030512 hasConcept C203014093 @default.
- W2097030512 hasConcept C2777583451 @default.
- W2097030512 hasConcept C2778461978 @default.
- W2097030512 hasConcept C2778729363 @default.
- W2097030512 hasConcept C3019892230 @default.
- W2097030512 hasConcept C42362537 @default.
- W2097030512 hasConcept C502942594 @default.
- W2097030512 hasConcept C54355233 @default.
- W2097030512 hasConcept C62478195 @default.
- W2097030512 hasConcept C71924100 @default.
- W2097030512 hasConcept C81885089 @default.
- W2097030512 hasConcept C86803240 @default.
- W2097030512 hasConcept C95444343 @default.
- W2097030512 hasConceptScore W2097030512C125418893 @default.
- W2097030512 hasConceptScore W2097030512C171122931 @default.
- W2097030512 hasConceptScore W2097030512C190283241 @default.
- W2097030512 hasConceptScore W2097030512C203014093 @default.
- W2097030512 hasConceptScore W2097030512C2777583451 @default.
- W2097030512 hasConceptScore W2097030512C2778461978 @default.
- W2097030512 hasConceptScore W2097030512C2778729363 @default.