FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097033810> ?p ?o ?g. }

• W2097033810 endingPage "6" @default.
• W2097033810 startingPage "450" @default.
• W2097033810 abstract "The predictive utility of several biochemical parameters of 5-fluorouracil (5-FUra) action was evaluated in four murine colonic adenocarcinomas: 5-FUra-sensitive Tumor 38 and 5-FUra-resistant Tumors 07/A, 51 and 06/A. Thymidylate synthetase (TS) was determined by a tritiated 5-fluoro-2'-deoxyuridylate (FdUMP)-binding assay. Bolus 5-FUra (80 mg/kg, i.p.) administrated caused in all tumors a rapid decrease in free TS levels. Only Tumor 38, however, showed inhibition of TS to undetectable (less than 0.05 pmol/g) levels, which lasted up to 6 hr after treatment; correction for dissociation of endogenous TS: FdUMP:folate ternary complex during the TS assay was required. Total TS (free enzyme plus ternary complex) was determined with experimental conditions that achieved quantitative recovery of free TS from ternary complex. By 48 hr after 5-FUra, Tumor 38 showed a decrease in total TS proportional to the estimated log kill/dose of 5-FUra; in contrast, the resistant tumors showed no such decrease from pretreatment levels. Assay of FdUMP showed that the free nucleotide was formed rapidly in all tumors in excess over available TS-binding sites. However, tumor sensitivity did not correlate with peak or residual FdUMP levels or with deoxyuridylate levels, which were low and remained so in all tumors. Tumor sensitivity to 5-FUra also could not be explained by the small differences among the tumors in total perchloric acid-soluble metabolites of 5-FUra or drug incorporation into RNA. We conclude from these data that levels of free TS in the tumor after 5-FUra treatment are predictive of chemotherapeutic response in these murine models of human colonic adenocarcinoma." @default.
• W2097033810 created "2016-06-24" @default.
• W2097033810 creator A5012266215 @default.
• W2097033810 creator A5032651935 @default.
• W2097033810 creator A5036493105 @default.
• W2097033810 creator A5077065335 @default.
• W2097033810 creator A5077120756 @default.
• W2097033810 date "1982-02-01" @default.
• W2097033810 modified "2023-09-23" @default.
• W2097033810 title "In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas." @default.
• W2097033810 cites W1479960751 @default.
• W2097033810 cites W1484304115 @default.
• W2097033810 cites W1485678634 @default.
• W2097033810 cites W1487046624 @default.
• W2097033810 cites W1490806706 @default.
• W2097033810 cites W1518352470 @default.
• W2097033810 cites W1522357622 @default.
• W2097033810 cites W1522838898 @default.
• W2097033810 cites W1524929003 @default.
• W2097033810 cites W1525939557 @default.
• W2097033810 cites W1544230518 @default.
• W2097033810 cites W1556164072 @default.
• W2097033810 cites W1575223772 @default.
• W2097033810 cites W1585780501 @default.
• W2097033810 cites W1603376393 @default.
• W2097033810 cites W1622813343 @default.
• W2097033810 cites W1679421997 @default.
• W2097033810 cites W1967995815 @default.
• W2097033810 cites W1970310258 @default.
• W2097033810 cites W1980418377 @default.
• W2097033810 cites W1980735579 @default.
• W2097033810 cites W1989700877 @default.
• W2097033810 cites W1998559191 @default.
• W2097033810 cites W2003984058 @default.
• W2097033810 cites W2017800701 @default.
• W2097033810 cites W2018641677 @default.
• W2097033810 cites W2040850705 @default.
• W2097033810 cites W2042230671 @default.
• W2097033810 cites W2044717712 @default.
• W2097033810 cites W2045714210 @default.
• W2097033810 cites W2051760741 @default.
• W2097033810 cites W2081984586 @default.
• W2097033810 cites W2082973931 @default.
• W2097033810 cites W2087491576 @default.
• W2097033810 cites W2087589957 @default.
• W2097033810 cites W2093657716 @default.
• W2097033810 cites W2094812775 @default.
• W2097033810 cites W2101316061 @default.
• W2097033810 cites W2167847781 @default.
• W2097033810 cites W2330278542 @default.
• W2097033810 cites W2399461665 @default.
• W2097033810 cites W2409522603 @default.
• W2097033810 cites W2410387248 @default.
• W2097033810 cites W2467811085 @default.
• W2097033810 cites W2528707387 @default.
• W2097033810 cites W2983850269 @default.
• W2097033810 cites W616358053 @default.
• W2097033810 cites W1540192039 @default.
• W2097033810 cites W2750817056 @default.
• W2097033810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6173112" @default.
• W2097033810 hasPublicationYear "1982" @default.
• W2097033810 type Work @default.
• W2097033810 sameAs 2097033810 @default.
• W2097033810 citedByCount "117" @default.
• W2097033810 countsByYear W20970338102014 @default.
• W2097033810 countsByYear W20970338102015 @default.
• W2097033810 countsByYear W20970338102017 @default.
• W2097033810 countsByYear W20970338102020 @default.
• W2097033810 countsByYear W20970338102022 @default.
• W2097033810 crossrefType "journal-article" @default.
• W2097033810 hasAuthorship W2097033810A5012266215 @default.
• W2097033810 hasAuthorship W2097033810A5032651935 @default.
• W2097033810 hasAuthorship W2097033810A5036493105 @default.
• W2097033810 hasAuthorship W2097033810A5077065335 @default.
• W2097033810 hasAuthorship W2097033810A5077120756 @default.
• W2097033810 hasConcept C104317684 @default.
• W2097033810 hasConcept C123321153 @default.
• W2097033810 hasConcept C126322002 @default.
• W2097033810 hasConcept C150903083 @default.
• W2097033810 hasConcept C153911025 @default.
• W2097033810 hasConcept C170493617 @default.
• W2097033810 hasConcept C181199279 @default.
• W2097033810 hasConcept C185592680 @default.
• W2097033810 hasConcept C207001950 @default.
• W2097033810 hasConcept C2776694085 @default.
• W2097033810 hasConcept C2780456651 @default.
• W2097033810 hasConcept C512185932 @default.
• W2097033810 hasConcept C55493867 @default.
• W2097033810 hasConcept C71924100 @default.
• W2097033810 hasConcept C74998103 @default.
• W2097033810 hasConcept C86756495 @default.
• W2097033810 hasConcept C86803240 @default.
• W2097033810 hasConceptScore W2097033810C104317684 @default.
• W2097033810 hasConceptScore W2097033810C123321153 @default.
• W2097033810 hasConceptScore W2097033810C126322002 @default.
• W2097033810 hasConceptScore W2097033810C150903083 @default.
• W2097033810 hasConceptScore W2097033810C153911025 @default.
• W2097033810 hasConceptScore W2097033810C170493617 @default.

• next