Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097053141> ?p ?o ?g. }
- W2097053141 endingPage "382" @default.
- W2097053141 startingPage "372" @default.
- W2097053141 abstract "Abstract Traditionally, PGD2 has been considered to be a pro-inflammatory mediator, acting via classical PG receptors, such as the PGD2 receptor (DP). PGD2 is degraded rapidly in vitro and in vivo to a variety of metabolites, the majority of which were thought, until recently, to be physiologically inactive. Several “inactive” metabolites, particularly 15d-PGJ2, have been shown to have wide-ranging effects on leukocytes and other cell types, however, and a potentially important anti-inflammatory role for PGD2 has now been recognized, and the complexity of PGD2 signaling is beginning to be elucidated. PGD2 and its metabolites are biologically active over a broad concentration range, and, intriquingly, it appears that there are marked concentration-dependent variations in the consequences of signaling by these eicosanoids, which have the potential to exert pro- and anti-inflammatory effects. For example, the actions of PGD2 can influence multiple stages in the life of the mature eosinophil, from causing its release from the bone marrow to inducing its recruitment and activation and, ultimately, regulating its apoptosis. This review is concerned with the diverse responses induced in leukocytes by PGD2 and its metabolites and the signaling mechanisms which are thought to be responsible for them." @default.
- W2097053141 created "2016-06-24" @default.
- W2097053141 creator A5015425059 @default.
- W2097053141 creator A5032808351 @default.
- W2097053141 creator A5064238838 @default.
- W2097053141 date "2006-10-16" @default.
- W2097053141 modified "2023-10-17" @default.
- W2097053141 title "Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function" @default.
- W2097053141 cites W1493450972 @default.
- W2097053141 cites W1494611500 @default.
- W2097053141 cites W1494617804 @default.
- W2097053141 cites W1500830863 @default.
- W2097053141 cites W1510733531 @default.
- W2097053141 cites W1511195742 @default.
- W2097053141 cites W1539392991 @default.
- W2097053141 cites W1544326688 @default.
- W2097053141 cites W1565847282 @default.
- W2097053141 cites W1633340712 @default.
- W2097053141 cites W1639924204 @default.
- W2097053141 cites W1680932833 @default.
- W2097053141 cites W1779958125 @default.
- W2097053141 cites W1812573520 @default.
- W2097053141 cites W1822329757 @default.
- W2097053141 cites W1852647106 @default.
- W2097053141 cites W1964073342 @default.
- W2097053141 cites W1967312698 @default.
- W2097053141 cites W1969428124 @default.
- W2097053141 cites W1969724362 @default.
- W2097053141 cites W1971595233 @default.
- W2097053141 cites W1973374536 @default.
- W2097053141 cites W1980109320 @default.
- W2097053141 cites W1982158616 @default.
- W2097053141 cites W1989121880 @default.
- W2097053141 cites W1994346978 @default.
- W2097053141 cites W1995012288 @default.
- W2097053141 cites W1996267589 @default.
- W2097053141 cites W1996614035 @default.
- W2097053141 cites W2003503281 @default.
- W2097053141 cites W2005674716 @default.
- W2097053141 cites W2010027879 @default.
- W2097053141 cites W2019460200 @default.
- W2097053141 cites W2027042060 @default.
- W2097053141 cites W2027223183 @default.
- W2097053141 cites W2028098820 @default.
- W2097053141 cites W2030634089 @default.
- W2097053141 cites W2036963336 @default.
- W2097053141 cites W2043757160 @default.
- W2097053141 cites W2050717908 @default.
- W2097053141 cites W2053513948 @default.
- W2097053141 cites W2054492884 @default.
- W2097053141 cites W2056605709 @default.
- W2097053141 cites W2057450814 @default.
- W2097053141 cites W2057530935 @default.
- W2097053141 cites W2063665402 @default.
- W2097053141 cites W2063924884 @default.
- W2097053141 cites W2064208521 @default.
- W2097053141 cites W2065289082 @default.
- W2097053141 cites W2066882388 @default.
- W2097053141 cites W2071264144 @default.
- W2097053141 cites W2073651858 @default.
- W2097053141 cites W2074808191 @default.
- W2097053141 cites W2074834459 @default.
- W2097053141 cites W2079644509 @default.
- W2097053141 cites W2083616068 @default.
- W2097053141 cites W2086622665 @default.
- W2097053141 cites W2088146922 @default.
- W2097053141 cites W2089043582 @default.
- W2097053141 cites W2091181345 @default.
- W2097053141 cites W2096461459 @default.
- W2097053141 cites W2096704046 @default.
- W2097053141 cites W2097096084 @default.
- W2097053141 cites W2097289392 @default.
- W2097053141 cites W2100705331 @default.
- W2097053141 cites W2103017931 @default.
- W2097053141 cites W2103069823 @default.
- W2097053141 cites W2110877905 @default.
- W2097053141 cites W2118949363 @default.
- W2097053141 cites W2122477020 @default.
- W2097053141 cites W2128663076 @default.
- W2097053141 cites W2130066981 @default.
- W2097053141 cites W2130414223 @default.
- W2097053141 cites W2144465917 @default.
- W2097053141 cites W2146825863 @default.
- W2097053141 cites W2149301267 @default.
- W2097053141 cites W2154365840 @default.
- W2097053141 cites W2156783332 @default.
- W2097053141 cites W2156797817 @default.
- W2097053141 cites W2160496147 @default.
- W2097053141 cites W2160634538 @default.
- W2097053141 cites W2163870925 @default.
- W2097053141 cites W2166735590 @default.
- W2097053141 cites W2166893697 @default.
- W2097053141 cites W2166955032 @default.
- W2097053141 cites W2167691893 @default.
- W2097053141 cites W2170261518 @default.
- W2097053141 cites W2171428713 @default.
- W2097053141 cites W2184417866 @default.
- W2097053141 cites W2227444936 @default.