Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097053175> ?p ?o ?g. }
- W2097053175 endingPage "1084" @default.
- W2097053175 startingPage "1069" @default.
- W2097053175 abstract "Biogenic amine transporters for serotonin and norepinephrine (5-HT and NE respectively), are major targets for currently available antidepressant drugs, particularly those inhibiting the reuptake of 5-HT and/or NE. Compelling evidence suggest that dopamine (DA) is also involved in the pathophysiology and treatment of depression, leading to the development of a new class of antidepressants: the triple reuptake inhibitors that simultaneously inhibit 5-HT, NE and DA reuptake thereby prolonging their duration of action at postsynaptic levels. Although preclinical studies strongly suggest that triple reuptake inhibitors display antidepressant-like activity in various behavioural paradigms, including the forced swimming and the tail suspension tests, it has yet to be demonstrated that the addition of the dopaminergic component produces more robust effects than single- or dual-acting compounds. Several arguments favour this hypothesis and particularly the observation that DA may promote neurotrophic processes in the adult hippocampus, as 5-HT and NE do. It is thus possible that the stimulation of multiple signalling pathways resulting from the elevation of all three monoamines may account, in part, for an accelerated and/or greater antidepressant response. To predict the efficacy of triple reuptake inhibitors, it is important to take into consideration the existence of dense connections between monoaminergic neurons. Indeed, it is well established that the increase in central dopaminergic transmission regulates the neuronal activity of 5-HT and NE in the dorsal raphe (DR) and locus coeruleus (LC), respectively, while in turn, the ventral tegmental area (VTA), is sensitive to changes in 5-HT and NE release. This review synthetizes the pertinent litterature, focusing on the contribution of DA, to illustrate the rationale for designing improved antidepressants." @default.
- W2097053175 created "2016-06-24" @default.
- W2097053175 creator A5002538047 @default.
- W2097053175 creator A5014960520 @default.
- W2097053175 creator A5056801799 @default.
- W2097053175 date "2009-11-01" @default.
- W2097053175 modified "2023-09-23" @default.
- W2097053175 title "Prospect of a Dopamine Contribution in the Next Generation of Antidepressant Drugs: The Triple Reuptake Inhibitors" @default.
- W2097053175 cites W108869947 @default.
- W2097053175 cites W1245441972 @default.
- W2097053175 cites W1493305388 @default.
- W2097053175 cites W1509868652 @default.
- W2097053175 cites W1514724839 @default.
- W2097053175 cites W1554279409 @default.
- W2097053175 cites W1558271214 @default.
- W2097053175 cites W1582206225 @default.
- W2097053175 cites W17887401 @default.
- W2097053175 cites W1796828557 @default.
- W2097053175 cites W1830466312 @default.
- W2097053175 cites W1850225444 @default.
- W2097053175 cites W18716524 @default.
- W2097053175 cites W1910313789 @default.
- W2097053175 cites W1928463227 @default.
- W2097053175 cites W1964770587 @default.
- W2097053175 cites W1964783728 @default.
- W2097053175 cites W1965716206 @default.
- W2097053175 cites W1969107429 @default.
- W2097053175 cites W1970498796 @default.
- W2097053175 cites W1973862432 @default.
- W2097053175 cites W1974737100 @default.
- W2097053175 cites W1975798497 @default.
- W2097053175 cites W1976295504 @default.
- W2097053175 cites W1978926207 @default.
- W2097053175 cites W1979231092 @default.
- W2097053175 cites W1979420282 @default.
- W2097053175 cites W1980078544 @default.
- W2097053175 cites W1980719669 @default.
- W2097053175 cites W1982954842 @default.
- W2097053175 cites W1983415715 @default.
- W2097053175 cites W1984113489 @default.
- W2097053175 cites W1988574111 @default.
- W2097053175 cites W1990128139 @default.
- W2097053175 cites W1990299071 @default.
- W2097053175 cites W1990454576 @default.
- W2097053175 cites W1990858302 @default.
- W2097053175 cites W1991246155 @default.
- W2097053175 cites W1992478337 @default.
- W2097053175 cites W1992569134 @default.
- W2097053175 cites W1993635001 @default.
- W2097053175 cites W1993889760 @default.
- W2097053175 cites W1995556701 @default.
- W2097053175 cites W1997065612 @default.
- W2097053175 cites W1997200668 @default.
- W2097053175 cites W1998148889 @default.
- W2097053175 cites W1998613952 @default.
- W2097053175 cites W1998767099 @default.
- W2097053175 cites W1999721747 @default.
- W2097053175 cites W2001023145 @default.
- W2097053175 cites W2001919680 @default.
- W2097053175 cites W2002297608 @default.
- W2097053175 cites W2002632542 @default.
- W2097053175 cites W2002834809 @default.
- W2097053175 cites W2003973769 @default.
- W2097053175 cites W2004080775 @default.
- W2097053175 cites W2004532068 @default.
- W2097053175 cites W2005159512 @default.
- W2097053175 cites W2005594217 @default.
- W2097053175 cites W2006972278 @default.
- W2097053175 cites W2007245256 @default.
- W2097053175 cites W2007746109 @default.
- W2097053175 cites W2008681321 @default.
- W2097053175 cites W2009642229 @default.
- W2097053175 cites W2010269783 @default.
- W2097053175 cites W2011918414 @default.
- W2097053175 cites W2012760196 @default.
- W2097053175 cites W2013507314 @default.
- W2097053175 cites W2014203063 @default.
- W2097053175 cites W2014580636 @default.
- W2097053175 cites W2018008180 @default.
- W2097053175 cites W2018818798 @default.
- W2097053175 cites W2019376105 @default.
- W2097053175 cites W2020482953 @default.
- W2097053175 cites W2026301477 @default.
- W2097053175 cites W2026784040 @default.
- W2097053175 cites W2027304084 @default.
- W2097053175 cites W2027495209 @default.
- W2097053175 cites W2028701653 @default.
- W2097053175 cites W2031845550 @default.
- W2097053175 cites W2032134562 @default.
- W2097053175 cites W2035421865 @default.
- W2097053175 cites W2036346162 @default.
- W2097053175 cites W2036700635 @default.
- W2097053175 cites W2037788330 @default.
- W2097053175 cites W2038449957 @default.
- W2097053175 cites W2038664574 @default.
- W2097053175 cites W2040295810 @default.
- W2097053175 cites W2041780263 @default.
- W2097053175 cites W2043097301 @default.