FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097053676> ?p ?o ?g. }

• W2097053676 endingPage "2093" @default.
• W2097053676 startingPage "2083" @default.
• W2097053676 abstract "ABSTRACT Rhodococcus equi is an important cause of pneumonia in young horses; however, adult horses are immune due to their ability to mount protective recall responses. In this study, the hypothesis that R. equi -specific cytotoxic T lymphocytes (CTL) are present in the lung of immune horses was tested. Bronchoalveolar lavage (BAL)-derived pulmonary T lymphocytes stimulated with R. equi lysed infected alveolar macrophages and peripheral blood adherent cells (PBAC). As with CTL obtained from the blood, killing of R. equi -infected targets by pulmonary effectors was not restricted by equine lymphocyte alloantigen-A (ELA-A; classical major histocompatibility complex class I), suggesting a novel or nonclassical method of antigen presentation. To determine whether or not CTL activity coincided with the age-associated susceptibility to rhodococcal pneumonia, CTL were evaluated in foals. R. equi- stimulated peripheral blood mononuclear cells (PBMC) from 3-week-old foals were unable to lyse either autologous perinatal or mismatched adult PBAC targets. The defect was not with the perinatal targets, as adult CTL effectors efficiently killed infected targets from 3-week-old foals. In contrast, significant CTL activity was present in three of five foals at 6 weeks of age, and significant specific lysis was induced by PBMC from all foals at 8 weeks of age. As with adults, lysis was ELA-A unrestricted. Two previously described monoclonal antibodies, BCD1b3 and CD1F2/1B12.1, were used to examine the expression of CD1, a nonclassical antigen-presenting molecule, on CTL targets. These antibodies cross-reacted with both foal and adult PBAC. However, neither antibody bound alveolar macrophages, suggesting that the R. equi -specific, major histocompatibility complex-unrestricted lysis is not restricted by a surface molecule identified by these antibodies." @default.
• W2097053676 created "2016-06-24" @default.
• W2097053676 creator A5021757427 @default.
• W2097053676 creator A5025392807 @default.
• W2097053676 creator A5037864506 @default.
• W2097053676 creator A5046054911 @default.
• W2097053676 creator A5064022095 @default.
• W2097053676 date "2005-04-01" @default.
• W2097053676 modified "2023-10-18" @default.
• W2097053676 title "<i>Rhodococcus equi</i> -Specific Cytotoxic T Lymphocytes in Immune Horses and Development in Asymptomatic Foals" @default.
• W2097053676 cites W1480426628 @default.
• W2097053676 cites W1508427423 @default.
• W2097053676 cites W1521353535 @default.
• W2097053676 cites W1597820912 @default.
• W2097053676 cites W1643563852 @default.
• W2097053676 cites W1767032442 @default.
• W2097053676 cites W1820901106 @default.
• W2097053676 cites W1831318282 @default.
• W2097053676 cites W1895837719 @default.
• W2097053676 cites W1913627479 @default.
• W2097053676 cites W1962880116 @default.
• W2097053676 cites W1965628324 @default.
• W2097053676 cites W1983868415 @default.
• W2097053676 cites W1984997549 @default.
• W2097053676 cites W1989709416 @default.
• W2097053676 cites W2003032572 @default.
• W2097053676 cites W2010353184 @default.
• W2097053676 cites W2011351377 @default.
• W2097053676 cites W2011574541 @default.
• W2097053676 cites W2027679419 @default.
• W2097053676 cites W2028101838 @default.
• W2097053676 cites W2035275046 @default.
• W2097053676 cites W2039021319 @default.
• W2097053676 cites W2052584125 @default.
• W2097053676 cites W2064038768 @default.
• W2097053676 cites W2074507269 @default.
• W2097053676 cites W2084073463 @default.
• W2097053676 cites W2086662036 @default.
• W2097053676 cites W2088622941 @default.
• W2097053676 cites W2091215862 @default.
• W2097053676 cites W2104032269 @default.
• W2097053676 cites W2104964096 @default.
• W2097053676 cites W2108422430 @default.
• W2097053676 cites W2112884456 @default.
• W2097053676 cites W2120813027 @default.
• W2097053676 cites W2122952191 @default.
• W2097053676 cites W2140200525 @default.
• W2097053676 cites W2143511029 @default.
• W2097053676 cites W2148115090 @default.
• W2097053676 cites W2151895701 @default.
• W2097053676 cites W2160617431 @default.
• W2097053676 cites W2164291463 @default.
• W2097053676 cites W2402025848 @default.
• W2097053676 cites W2472280601 @default.
• W2097053676 cites W4246559977 @default.
• W2097053676 doi "https://doi.org/10.1128/iai.73.4.2083-2093.2005" @default.
• W2097053676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1087435" @default.
• W2097053676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15784549" @default.
• W2097053676 hasPublicationYear "2005" @default.
• W2097053676 type Work @default.
• W2097053676 sameAs 2097053676 @default.
• W2097053676 citedByCount "42" @default.
• W2097053676 countsByYear W20970536762012 @default.
• W2097053676 countsByYear W20970536762013 @default.
• W2097053676 countsByYear W20970536762014 @default.
• W2097053676 countsByYear W20970536762015 @default.
• W2097053676 countsByYear W20970536762016 @default.
• W2097053676 countsByYear W20970536762018 @default.
• W2097053676 countsByYear W20970536762020 @default.
• W2097053676 countsByYear W20970536762022 @default.
• W2097053676 crossrefType "journal-article" @default.
• W2097053676 hasAuthorship W2097053676A5021757427 @default.
• W2097053676 hasAuthorship W2097053676A5025392807 @default.
• W2097053676 hasAuthorship W2097053676A5037864506 @default.
• W2097053676 hasAuthorship W2097053676A5046054911 @default.
• W2097053676 hasAuthorship W2097053676A5064022095 @default.
• W2097053676 hasBestOaLocation W20970536761 @default.
• W2097053676 hasConcept C104317684 @default.
• W2097053676 hasConcept C126322002 @default.
• W2097053676 hasConcept C137061746 @default.
• W2097053676 hasConcept C147483822 @default.
• W2097053676 hasConcept C147969180 @default.
• W2097053676 hasConcept C154317977 @default.
• W2097053676 hasConcept C167672396 @default.
• W2097053676 hasConcept C202751555 @default.
• W2097053676 hasConcept C203014093 @default.
• W2097053676 hasConcept C2777581609 @default.
• W2097053676 hasConcept C2777714996 @default.
• W2097053676 hasConcept C2777961210 @default.
• W2097053676 hasConcept C55493867 @default.
• W2097053676 hasConcept C60987743 @default.
• W2097053676 hasConcept C71924100 @default.
• W2097053676 hasConcept C86803240 @default.
• W2097053676 hasConcept C8891405 @default.
• W2097053676 hasConceptScore W2097053676C104317684 @default.
• W2097053676 hasConceptScore W2097053676C126322002 @default.
• W2097053676 hasConceptScore W2097053676C137061746 @default.
• W2097053676 hasConceptScore W2097053676C147483822 @default.

• next