FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097058523> ?p ?o ?g. }

• W2097058523 abstract "Platelet gel is used to facilitate wound healing in virtue of the growth factors released from activated platelets at the site of lesion, but little is known about the specific mechanisms underlying cellular repair.To evaluate, in vitro, cellular effects of different concentrations of platelet gel -released supernatant on endothelial cells.Platelet concentrate was produced at the Service of Immunohaematology and Transfusion of San Salvatore Hospital of L'Aquila, using multiple bags. Platelet gel was obtained by adding thrombin and calcium gluconate to the concentrates and then centrifuging to recover the supernatant. Human umbilical vein endothelial cells were isolated from umbilical cord veins and grown in appropriate conditions. To study their viability, cells were treated with different concentrations of supernatant and XTT assays were performed on the 3 days following treatment. Endothelial cell motility and invasiveness were assayed using modified Boyden chambers with filters coated with 0.1% gelatin (for the motility test) or with a thick layer of the reconstituted basement membrane Matrigel (for the invasion test). The supernatant, added at various concentrations to the lower compartment of the chamber, was used as an attractant. Umbilical cells were added to the upper compartment of the chamber. After 4 hours (for the motility test) or 6 hours (for the invasion test), filters were stained and the migrated cells in five high-power fields were counted.When used at specific concentrations, platelet gel-released supernatant is able to induce proliferation and to stimulate motility and invasiveness of endothelial human cells. Higher concentrations induce a reversion of the stimulatory processes.There is a large body of evidence indicating that platelets and their derivatives have the potential for a substantial therapeutic role in tissue regeneration. The results of this in vitro study highlight the need for an in-depth analysis of technical protocols for the most appropriate and effective use of platelet gel for in vivo applications." @default.
• W2097058523 created "2016-06-24" @default.
• W2097058523 creator A5006143315 @default.
• W2097058523 creator A5011254660 @default.
• W2097058523 creator A5025510946 @default.
• W2097058523 creator A5045366127 @default.
• W2097058523 creator A5047129286 @default.
• W2097058523 creator A5047996304 @default.
• W2097058523 creator A5056358663 @default.
• W2097058523 creator A5076278669 @default.
• W2097058523 date "2008-01-01" @default.
• W2097058523 modified "2023-09-29" @default.
• W2097058523 title "Platelet gel-released supernatant modulates the angiogenic capability of human endothelial cells." @default.
• W2097058523 cites W135839998 @default.
• W2097058523 cites W1976619343 @default.
• W2097058523 cites W1997432933 @default.
• W2097058523 cites W2010394573 @default.
• W2097058523 cites W2057073473 @default.
• W2097058523 cites W2064413596 @default.
• W2097058523 cites W2071237033 @default.
• W2097058523 cites W2121985684 @default.
• W2097058523 cites W2149837482 @default.
• W2097058523 cites W2155836760 @default.
• W2097058523 cites W2167303139 @default.
• W2097058523 cites W28424370 @default.
• W2097058523 doi "https://doi.org/10.2450/2008.0026-07" @default.
• W2097058523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2626859" @default.
• W2097058523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18661919" @default.
• W2097058523 hasPublicationYear "2008" @default.
• W2097058523 type Work @default.
• W2097058523 sameAs 2097058523 @default.
• W2097058523 citedByCount "24" @default.
• W2097058523 countsByYear W20970585232012 @default.
• W2097058523 countsByYear W20970585232014 @default.
• W2097058523 countsByYear W20970585232016 @default.
• W2097058523 countsByYear W20970585232017 @default.
• W2097058523 countsByYear W20970585232018 @default.
• W2097058523 countsByYear W20970585232019 @default.
• W2097058523 countsByYear W20970585232020 @default.
• W2097058523 countsByYear W20970585232021 @default.
• W2097058523 countsByYear W20970585232022 @default.
• W2097058523 countsByYear W20970585232023 @default.
• W2097058523 crossrefType "journal-article" @default.
• W2097058523 hasAuthorship W2097058523A5006143315 @default.
• W2097058523 hasAuthorship W2097058523A5011254660 @default.
• W2097058523 hasAuthorship W2097058523A5025510946 @default.
• W2097058523 hasAuthorship W2097058523A5045366127 @default.
• W2097058523 hasAuthorship W2097058523A5047129286 @default.
• W2097058523 hasAuthorship W2097058523A5047996304 @default.
• W2097058523 hasAuthorship W2097058523A5056358663 @default.
• W2097058523 hasAuthorship W2097058523A5076278669 @default.
• W2097058523 hasConcept C123012128 @default.
• W2097058523 hasConcept C153911025 @default.
• W2097058523 hasConcept C16685009 @default.
• W2097058523 hasConcept C185592680 @default.
• W2097058523 hasConcept C202751555 @default.
• W2097058523 hasConcept C203014093 @default.
• W2097058523 hasConcept C2776955114 @default.
• W2097058523 hasConcept C2777411675 @default.
• W2097058523 hasConcept C2778608917 @default.
• W2097058523 hasConcept C2780269544 @default.
• W2097058523 hasConcept C3018697912 @default.
• W2097058523 hasConcept C55493867 @default.
• W2097058523 hasConcept C58207958 @default.
• W2097058523 hasConcept C71924100 @default.
• W2097058523 hasConcept C86803240 @default.
• W2097058523 hasConcept C89560881 @default.
• W2097058523 hasConcept C95444343 @default.
• W2097058523 hasConceptScore W2097058523C123012128 @default.
• W2097058523 hasConceptScore W2097058523C153911025 @default.
• W2097058523 hasConceptScore W2097058523C16685009 @default.
• W2097058523 hasConceptScore W2097058523C185592680 @default.
• W2097058523 hasConceptScore W2097058523C202751555 @default.
• W2097058523 hasConceptScore W2097058523C203014093 @default.
• W2097058523 hasConceptScore W2097058523C2776955114 @default.
• W2097058523 hasConceptScore W2097058523C2777411675 @default.
• W2097058523 hasConceptScore W2097058523C2778608917 @default.
• W2097058523 hasConceptScore W2097058523C2780269544 @default.
• W2097058523 hasConceptScore W2097058523C3018697912 @default.
• W2097058523 hasConceptScore W2097058523C55493867 @default.
• W2097058523 hasConceptScore W2097058523C58207958 @default.
• W2097058523 hasConceptScore W2097058523C71924100 @default.
• W2097058523 hasConceptScore W2097058523C86803240 @default.
• W2097058523 hasConceptScore W2097058523C89560881 @default.
• W2097058523 hasConceptScore W2097058523C95444343 @default.
• W2097058523 hasLocation W20970585231 @default.
• W2097058523 hasOpenAccess W2097058523 @default.
• W2097058523 hasPrimaryLocation W20970585231 @default.
• W2097058523 hasRelatedWork W1965740759 @default.
• W2097058523 hasRelatedWork W1981688423 @default.
• W2097058523 hasRelatedWork W1996837920 @default.
• W2097058523 hasRelatedWork W1997432933 @default.
• W2097058523 hasRelatedWork W2013518981 @default.
• W2097058523 hasRelatedWork W2020386168 @default.
• W2097058523 hasRelatedWork W2025371271 @default.
• W2097058523 hasRelatedWork W2030322516 @default.
• W2097058523 hasRelatedWork W2064413596 @default.
• W2097058523 hasRelatedWork W2066496557 @default.
• W2097058523 hasRelatedWork W2087122544 @default.
• W2097058523 hasRelatedWork W2088986145 @default.

• next