FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097063015> ?p ?o ?g. }

• W2097063015 endingPage "745" @default.
• W2097063015 startingPage "734" @default.
• W2097063015 abstract "Transdermal delivery is an attractive option for drug delivery. Nevertheless, the skin is a tough barrier and only a limited number of drugs can be delivered through it. The most difficult to deliver are hydrophilic drugs. The stinging mechanism of the cnidarians is a sophisticated injection system consisting of microcapsular nematocysts, which utilize built-in high osmotic pressures to inject a submicron tubule that penetrates and delivers their contents to the prey. Here we show, for the first time, that the nematocysts of the starlet sea anemone Nematostella vectensis can be isolated and incorporated into a topical formulation for continuous drug delivery. We demonstrate quantitative delivery of nicotinamide and lidocaine hydrochloride as a function of microcapsular dose or drug exposure. We also show how the released submicron tubules can be exploited as a skin penetration enhancer prior to and independently of drug application. The microcapsules are non-irritant and may offer an attractive alternative for hydrophilic transdermal drug delivery." @default.
• W2097063015 created "2016-06-24" @default.
• W2097063015 creator A5000853858 @default.
• W2097063015 creator A5010429226 @default.
• W2097063015 creator A5032651646 @default.
• W2097063015 creator A5044601012 @default.
• W2097063015 creator A5061281174 @default.
• W2097063015 creator A5089230652 @default.
• W2097063015 date "2014-01-27" @default.
• W2097063015 modified "2023-10-14" @default.
• W2097063015 title "Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules" @default.
• W2097063015 cites W1557587222 @default.
• W2097063015 cites W1973921177 @default.
• W2097063015 cites W1981760171 @default.
• W2097063015 cites W1997179621 @default.
• W2097063015 cites W2008690403 @default.
• W2097063015 cites W2012707344 @default.
• W2097063015 cites W2015918212 @default.
• W2097063015 cites W2033198837 @default.
• W2097063015 cites W2038667334 @default.
• W2097063015 cites W2041918105 @default.
• W2097063015 cites W2042434075 @default.
• W2097063015 cites W2042714094 @default.
• W2097063015 cites W2045456307 @default.
• W2097063015 cites W2051292995 @default.
• W2097063015 cites W2051313172 @default.
• W2097063015 cites W2054613350 @default.
• W2097063015 cites W2057007227 @default.
• W2097063015 cites W2060545726 @default.
• W2097063015 cites W2063202985 @default.
• W2097063015 cites W2067558229 @default.
• W2097063015 cites W2080430067 @default.
• W2097063015 cites W2081565890 @default.
• W2097063015 cites W2088875348 @default.
• W2097063015 cites W2096081781 @default.
• W2097063015 cites W2102078285 @default.
• W2097063015 cites W2109473195 @default.
• W2097063015 cites W2117369764 @default.
• W2097063015 cites W2151061073 @default.
• W2097063015 cites W2181665204 @default.
• W2097063015 cites W4231446881 @default.
• W2097063015 doi "https://doi.org/10.3390/md12020734" @default.
• W2097063015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3944512" @default.
• W2097063015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24473172" @default.
• W2097063015 hasPublicationYear "2014" @default.
• W2097063015 type Work @default.
• W2097063015 sameAs 2097063015 @default.
• W2097063015 citedByCount "9" @default.
• W2097063015 countsByYear W20970630152014 @default.
• W2097063015 countsByYear W20970630152016 @default.
• W2097063015 countsByYear W20970630152017 @default.
• W2097063015 countsByYear W20970630152019 @default.
• W2097063015 countsByYear W20970630152020 @default.
• W2097063015 countsByYear W20970630152021 @default.
• W2097063015 crossrefType "journal-article" @default.
• W2097063015 hasAuthorship W2097063015A5000853858 @default.
• W2097063015 hasAuthorship W2097063015A5010429226 @default.
• W2097063015 hasAuthorship W2097063015A5032651646 @default.
• W2097063015 hasAuthorship W2097063015A5044601012 @default.
• W2097063015 hasAuthorship W2097063015A5061281174 @default.
• W2097063015 hasAuthorship W2097063015A5089230652 @default.
• W2097063015 hasBestOaLocation W20970630151 @default.
• W2097063015 hasConcept C12554922 @default.
• W2097063015 hasConcept C143020374 @default.
• W2097063015 hasConcept C171250308 @default.
• W2097063015 hasConcept C185592680 @default.
• W2097063015 hasConcept C18903297 @default.
• W2097063015 hasConcept C192562407 @default.
• W2097063015 hasConcept C205679159 @default.
• W2097063015 hasConcept C2775939778 @default.
• W2097063015 hasConcept C2778089062 @default.
• W2097063015 hasConcept C2779356992 @default.
• W2097063015 hasConcept C2779820397 @default.
• W2097063015 hasConcept C2780021116 @default.
• W2097063015 hasConcept C2780035454 @default.
• W2097063015 hasConcept C2910315665 @default.
• W2097063015 hasConcept C32229687 @default.
• W2097063015 hasConcept C59822182 @default.
• W2097063015 hasConcept C86803240 @default.
• W2097063015 hasConcept C98274493 @default.
• W2097063015 hasConceptScore W2097063015C12554922 @default.
• W2097063015 hasConceptScore W2097063015C143020374 @default.
• W2097063015 hasConceptScore W2097063015C171250308 @default.
• W2097063015 hasConceptScore W2097063015C185592680 @default.
• W2097063015 hasConceptScore W2097063015C18903297 @default.
• W2097063015 hasConceptScore W2097063015C192562407 @default.
• W2097063015 hasConceptScore W2097063015C205679159 @default.
• W2097063015 hasConceptScore W2097063015C2775939778 @default.
• W2097063015 hasConceptScore W2097063015C2778089062 @default.
• W2097063015 hasConceptScore W2097063015C2779356992 @default.
• W2097063015 hasConceptScore W2097063015C2779820397 @default.
• W2097063015 hasConceptScore W2097063015C2780021116 @default.
• W2097063015 hasConceptScore W2097063015C2780035454 @default.
• W2097063015 hasConceptScore W2097063015C2910315665 @default.
• W2097063015 hasConceptScore W2097063015C32229687 @default.
• W2097063015 hasConceptScore W2097063015C59822182 @default.
• W2097063015 hasConceptScore W2097063015C86803240 @default.
• W2097063015 hasConceptScore W2097063015C98274493 @default.

• next