Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097071314> ?p ?o ?g. }
- W2097071314 endingPage "2834" @default.
- W2097071314 startingPage "2826" @default.
- W2097071314 abstract "Purpose Improved survival has been observed in aggressive non-Hodgkin's lymphoma (NHL) patients with adverse prognostic factors when autotransplantation (ASCT) was performed after complete remission. However, there is no agreement on the prognostic factors for patients treated with ASCT. We aimed to estimate the prognostic effect of clinical and biologic variables on relapse and survival rates by pooling the data from two trials. Patients and Methods Of the patients treated in the LNH87 and LNH93 trials, 330 under age 60 years achieved complete remission after high-dose cyclophosphamide, doxorubicin, vincristine, and prednisone, and received consolidative ASCT; 16% of patients had T-cell NHL. The International Prognostic Index (IPI) score was 0 for 11%, 1 for 23%, 2 for 51%, and 3 for 15%. Univariate and Cox multivariate survival analyses were retrospectively performed on this population. Results Overall survival was 75 ± 5% at 5 years and disease-free survival (DFS) 67 ± 5%. For T-cell NHL, these scores were 54% and 44%, respectively. The IPI score had no prognostic value and only the following parameters adversely affected overall survival and DFS (P < .05): marrow involvement; more than one extranodal site; histology (nonanaplastic T-cell v others); and type of anthracycline (mitoxantrone v doxorubicin, for DFS only). Conclusion These results suggest that ASCT can prevent relapse in patients with adverse IPI factors. However, patients presenting with a nonanaplastic T-cell phenotype, more than one extranodal site, or marrow involvement still have a higher risk of relapse. These factors should be taken into account when designing post-ASCT maintenance studies." @default.
- W2097071314 created "2016-06-24" @default.
- W2097071314 creator A5000549535 @default.
- W2097071314 creator A5006559442 @default.
- W2097071314 creator A5010990164 @default.
- W2097071314 creator A5014931705 @default.
- W2097071314 creator A5031041032 @default.
- W2097071314 creator A5033073385 @default.
- W2097071314 creator A5040015241 @default.
- W2097071314 creator A5044625155 @default.
- W2097071314 creator A5051605599 @default.
- W2097071314 creator A5052167942 @default.
- W2097071314 creator A5061006030 @default.
- W2097071314 creator A5065987951 @default.
- W2097071314 creator A5069745915 @default.
- W2097071314 creator A5086774598 @default.
- W2097071314 date "2004-07-15" @default.
- W2097071314 modified "2023-10-07" @default.
- W2097071314 title "Prognostic Factors in Patients With Aggressive Non-Hodgkin's Lymphoma Treated by Front-Line Autotransplantation After Complete Remission: A Cohort Study by the Groupe d'Etude des Lymphomes de l'Adulte" @default.
- W2097071314 cites W1544519462 @default.
- W2097071314 cites W1570622790 @default.
- W2097071314 cites W1819949687 @default.
- W2097071314 cites W1896652710 @default.
- W2097071314 cites W1898622368 @default.
- W2097071314 cites W1901299664 @default.
- W2097071314 cites W1912693401 @default.
- W2097071314 cites W1976564639 @default.
- W2097071314 cites W1997353354 @default.
- W2097071314 cites W2022872665 @default.
- W2097071314 cites W2057508802 @default.
- W2097071314 cites W2058015212 @default.
- W2097071314 cites W2064208261 @default.
- W2097071314 cites W2066730945 @default.
- W2097071314 cites W2073151455 @default.
- W2097071314 cites W2117291755 @default.
- W2097071314 cites W2117897510 @default.
- W2097071314 cites W2131508403 @default.
- W2097071314 cites W2142334769 @default.
- W2097071314 cites W2147246240 @default.
- W2097071314 cites W2149617816 @default.
- W2097071314 cites W2161026651 @default.
- W2097071314 cites W2167237412 @default.
- W2097071314 cites W2318772898 @default.
- W2097071314 cites W2339293928 @default.
- W2097071314 cites W2520536150 @default.
- W2097071314 cites W3147894994 @default.
- W2097071314 cites W4205736005 @default.
- W2097071314 cites W4293241248 @default.
- W2097071314 cites W4324121477 @default.
- W2097071314 doi "https://doi.org/10.1200/jco.2004.12.032" @default.
- W2097071314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15254050" @default.
- W2097071314 hasPublicationYear "2004" @default.
- W2097071314 type Work @default.
- W2097071314 sameAs 2097071314 @default.
- W2097071314 citedByCount "59" @default.
- W2097071314 countsByYear W20970713142012 @default.
- W2097071314 countsByYear W20970713142013 @default.
- W2097071314 countsByYear W20970713142014 @default.
- W2097071314 countsByYear W20970713142015 @default.
- W2097071314 countsByYear W20970713142016 @default.
- W2097071314 countsByYear W20970713142019 @default.
- W2097071314 countsByYear W20970713142021 @default.
- W2097071314 crossrefType "journal-article" @default.
- W2097071314 hasAuthorship W2097071314A5000549535 @default.
- W2097071314 hasAuthorship W2097071314A5006559442 @default.
- W2097071314 hasAuthorship W2097071314A5010990164 @default.
- W2097071314 hasAuthorship W2097071314A5014931705 @default.
- W2097071314 hasAuthorship W2097071314A5031041032 @default.
- W2097071314 hasAuthorship W2097071314A5033073385 @default.
- W2097071314 hasAuthorship W2097071314A5040015241 @default.
- W2097071314 hasAuthorship W2097071314A5044625155 @default.
- W2097071314 hasAuthorship W2097071314A5051605599 @default.
- W2097071314 hasAuthorship W2097071314A5052167942 @default.
- W2097071314 hasAuthorship W2097071314A5061006030 @default.
- W2097071314 hasAuthorship W2097071314A5065987951 @default.
- W2097071314 hasAuthorship W2097071314A5069745915 @default.
- W2097071314 hasAuthorship W2097071314A5086774598 @default.
- W2097071314 hasConcept C126322002 @default.
- W2097071314 hasConcept C141071460 @default.
- W2097071314 hasConcept C143998085 @default.
- W2097071314 hasConcept C144301174 @default.
- W2097071314 hasConcept C2776694085 @default.
- W2097071314 hasConcept C2776755627 @default.
- W2097071314 hasConcept C2778476033 @default.
- W2097071314 hasConcept C2778559949 @default.
- W2097071314 hasConcept C2779338263 @default.
- W2097071314 hasConcept C2779429289 @default.
- W2097071314 hasConcept C2779714933 @default.
- W2097071314 hasConcept C2780653079 @default.
- W2097071314 hasConcept C2780923524 @default.
- W2097071314 hasConcept C2781214270 @default.
- W2097071314 hasConcept C2908647359 @default.
- W2097071314 hasConcept C38180746 @default.
- W2097071314 hasConcept C71924100 @default.
- W2097071314 hasConcept C90924648 @default.
- W2097071314 hasConcept C99454951 @default.
- W2097071314 hasConceptScore W2097071314C126322002 @default.
- W2097071314 hasConceptScore W2097071314C141071460 @default.