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• W2097098623 startingPage "3020" @default.
• W2097098623 abstract "Axin antagonizes the developmental effects of Wnt in vertebrates. We show here that Axin simultaneously binds two components of the Wnt pathway, β-catenin and its negative regulator glycogen synthase kinase-3β. In mammalian cells, Axin inhibits Wnt-1 stimulation of β-catenin/lymphoid enhancer factor 1-dependent transcription. Axin also blocks β-catenin-mediated transcription in colon cancer cells that have a mutation in the adenomatous polyposis coli gene. These findings suggest that Axin, by forming a complex with β-catenin and glycogen synthase kinase-3β, can block signaling stimulated by Wnt or by adenomatous polyposis coli mutations." @default.
• W2097098623 created "2016-06-24" @default.
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• W2097098623 creator A5043030783 @default.
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• W2097098623 date "1998-03-17" @default.
• W2097098623 modified "2023-10-16" @default.
• W2097098623 title "Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription" @default.
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• W2097098623 doi "https://doi.org/10.1073/pnas.95.6.3020" @default.
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