FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097104496> ?p ?o ?g. }

• W2097104496 endingPage "1231" @default.
• W2097104496 startingPage "1223" @default.
• W2097104496 abstract "Background Bcl-2 protects cells from apoptosis and provides a survival advantage to cells over-expressing this oncogene. In addition, over expression of Bcl-2 renders cell resistant to radiation therapy. Recently, dichloroacetate (DCA) was proven to potentiate the apoptotic machinery by interacting with Bcl-2. In this study, we investigated whether treating human prostate cancer cells with DCA could modulate Bcl-2 expression and if the modulation in Bcl-2 expression could render the Bcl-2 over expressing cells more susceptible to cytotoxicity effects of radiation. Methods PC-3-Bcl-2 and PC-3-Neo human prostate cancer cells treated with DCA in addition to irradiation were analyzed in vitro for changes in proliferation, clonogenic survival, apoptosis, cell cycle phase distribution, mitochondrial membrane potential, and expression of Bcl-2, Bcl-xL, Bax, or Bak proteins. Results DCA alone produced significant cytotoxic effects and was associated with G1 cell cycle arrest. Furthermore, DCA was associated with an increased rate of apoptosis. The combination of DCA with irradiation sensitized both cell lines to radiation's killing effects. Treatment of PC-3-Bcl-2 or PC-3-Neo with DCA and irradiation resulted in marked changes in various members of the Bcl-2 family. In addition, DCA therapy resulted in a significant change in mitochondria membrane potential, thus supporting the notion that DCAs effect is on the mitochondria. Conclusions This is the first study to demonstrate DCA can effectively sensitize wild-type and over expressing Bcl-2 human prostate cancer cells to radiation by modulating the expression of key members of the Bcl-2 family. Together, these findings warrant further evaluation of the combination of DCA and irradiation. Prostate 68: 1223–1231, 2008. © 2008 Wiley-Liss, Inc." @default.
• W2097104496 created "2016-06-24" @default.
• W2097104496 creator A5016395647 @default.
• W2097104496 creator A5017877251 @default.
• W2097104496 creator A5024594616 @default.
• W2097104496 creator A5027921186 @default.
• W2097104496 creator A5062727443 @default.
• W2097104496 creator A5078910709 @default.
• W2097104496 creator A5082611981 @default.
• W2097104496 creator A5084778350 @default.
• W2097104496 date "2008-08-01" @default.
• W2097104496 modified "2023-10-03" @default.
• W2097104496 title "Dichloroacetate (DCA) sensitizes both wild‐type and over expressing<i>Bcl‐2</i>prostate cancer cells in vitro to radiation" @default.
• W2097104496 cites W145522988 @default.
• W2097104496 cites W1503815793 @default.
• W2097104496 cites W1528048211 @default.
• W2097104496 cites W1987484894 @default.
• W2097104496 cites W1990050184 @default.
• W2097104496 cites W1999078834 @default.
• W2097104496 cites W2004445019 @default.
• W2097104496 cites W2016269970 @default.
• W2097104496 cites W2021499491 @default.
• W2097104496 cites W2023374425 @default.
• W2097104496 cites W2023711180 @default.
• W2097104496 cites W2026334721 @default.
• W2097104496 cites W2026743900 @default.
• W2097104496 cites W2030735294 @default.
• W2097104496 cites W2040506871 @default.
• W2097104496 cites W2056643793 @default.
• W2097104496 cites W2061744669 @default.
• W2097104496 cites W2080200822 @default.
• W2097104496 cites W2092373769 @default.
• W2097104496 cites W2092879394 @default.
• W2097104496 cites W2095346194 @default.
• W2097104496 cites W2117792530 @default.
• W2097104496 cites W2123753866 @default.
• W2097104496 cites W2124221273 @default.
• W2097104496 cites W2127742497 @default.
• W2097104496 cites W2132955042 @default.
• W2097104496 cites W2144498681 @default.
• W2097104496 cites W2149755406 @default.
• W2097104496 cites W2151260260 @default.
• W2097104496 cites W2152772600 @default.
• W2097104496 cites W2336950143 @default.
• W2097104496 doi "https://doi.org/10.1002/pros.20788" @default.
• W2097104496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18465755" @default.
• W2097104496 hasPublicationYear "2008" @default.
• W2097104496 type Work @default.
• W2097104496 sameAs 2097104496 @default.
• W2097104496 citedByCount "176" @default.
• W2097104496 countsByYear W20971044962012 @default.
• W2097104496 countsByYear W20971044962013 @default.
• W2097104496 countsByYear W20971044962014 @default.
• W2097104496 countsByYear W20971044962015 @default.
• W2097104496 countsByYear W20971044962016 @default.
• W2097104496 countsByYear W20971044962017 @default.
• W2097104496 countsByYear W20971044962018 @default.
• W2097104496 countsByYear W20971044962019 @default.
• W2097104496 countsByYear W20971044962020 @default.
• W2097104496 countsByYear W20971044962021 @default.
• W2097104496 countsByYear W20971044962022 @default.
• W2097104496 countsByYear W20971044962023 @default.
• W2097104496 crossrefType "journal-article" @default.
• W2097104496 hasAuthorship W2097104496A5016395647 @default.
• W2097104496 hasAuthorship W2097104496A5017877251 @default.
• W2097104496 hasAuthorship W2097104496A5024594616 @default.
• W2097104496 hasAuthorship W2097104496A5027921186 @default.
• W2097104496 hasAuthorship W2097104496A5062727443 @default.
• W2097104496 hasAuthorship W2097104496A5078910709 @default.
• W2097104496 hasAuthorship W2097104496A5082611981 @default.
• W2097104496 hasAuthorship W2097104496A5084778350 @default.
• W2097104496 hasConcept C105696609 @default.
• W2097104496 hasConcept C117262875 @default.
• W2097104496 hasConcept C121608353 @default.
• W2097104496 hasConcept C126322002 @default.
• W2097104496 hasConcept C154317977 @default.
• W2097104496 hasConcept C190283241 @default.
• W2097104496 hasConcept C202751555 @default.
• W2097104496 hasConcept C2780192828 @default.
• W2097104496 hasConcept C28859421 @default.
• W2097104496 hasConcept C29537977 @default.
• W2097104496 hasConcept C31573885 @default.
• W2097104496 hasConcept C502942594 @default.
• W2097104496 hasConcept C54355233 @default.
• W2097104496 hasConcept C55493867 @default.
• W2097104496 hasConcept C71924100 @default.
• W2097104496 hasConcept C81885089 @default.
• W2097104496 hasConcept C86803240 @default.
• W2097104496 hasConcept C95444343 @default.
• W2097104496 hasConcept C96232424 @default.
• W2097104496 hasConceptScore W2097104496C105696609 @default.
• W2097104496 hasConceptScore W2097104496C117262875 @default.
• W2097104496 hasConceptScore W2097104496C121608353 @default.
• W2097104496 hasConceptScore W2097104496C126322002 @default.
• W2097104496 hasConceptScore W2097104496C154317977 @default.
• W2097104496 hasConceptScore W2097104496C190283241 @default.
• W2097104496 hasConceptScore W2097104496C202751555 @default.
• W2097104496 hasConceptScore W2097104496C2780192828 @default.

• next