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- W2097121594 abstract "Induction of antigen-specific T cell tolerance would aid treatment of diverse immunological disorders and help prevent allograft rejection and graft versus host disease. In this study, we establish a method of inducing antigen-specific T cell tolerance in situ in diabetic humanized mice and Rhesus monkeys receiving porcine islet xenografts. Antigen-specific T cell tolerance is induced by administration of an antibody ligating a particular epitope on ICAM-1 (intercellular adhesion molecule 1). Antibody-mediated ligation of ICAM-1 on dendritic cells (DCs) led to the arrest of DCs in a semimature stage in vitro and in vivo. Ablation of DCs from mice completely abrogated anti–ICAM-1–induced antigen-specific T cell tolerance. T cell responses to unrelated antigens remained unaffected. In situ induction of DC-mediated T cell tolerance using this method may represent a potent therapeutic tool for preventing graft rejection." @default.
- W2097121594 created "2016-06-24" @default.
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- W2097121594 date "2011-10-24" @default.
- W2097121594 modified "2023-10-10" @default.
- W2097121594 title "In situ induction of dendritic cell–based T cell tolerance in humanized mice and nonhuman primates" @default.
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- W2097121594 doi "https://doi.org/10.1084/jem.20111242" @default.
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