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• W2097125224 startingPage "857" @default.
• W2097125224 abstract "Based on enlarged blood oxygen level-dependent (BOLD) responses in cognitively normal subjects at risk for Alzheimer's disease (AD), compensatory neuronal hyperactivation has been proposed as an early marker for diagnosis of AD. The BOLD response results from neurovascular coupling, i.e., hemodynam ic response induced by neuronal activity. However, there has been no evidence of task-induced increases in hemodynamic response in animal models of AD. Here, we observed an augmented hemodynamic response pattern in a transgenic AβPPSWE/PS1ΔE9 mouse model of AD using three in vivo imaging methods: intrinsic optical signal imaging, multi-photon laser scanning microscopy, and laser Doppler flowmetry. Sensory stimulation resulted in augmented and prolonged hemodynamic responses in transgenic mice evidenced by changes in total, oxygenated, and deoxygenated hemoglobin concentration. This difference between transgenic and wild-type mice was significant at 7 months of age when amyloid plaques and cerebral amyloid angiopathy had developed but not at younger or older ages. Correspondingly, sensory stimulation-induced pial arteriole diameter was also augmented and prolonged in transgenic mice at 7 months of age. Cerebral blood flow response in transgenic mice was augmented but not prolonged. These results are consistent with the existence of BOLD signal hyperactivation in non-demented AD-risk human subjects, supporting its potential use as an early diagnostic marker of AD." @default.
• W2097125224 created "2016-06-24" @default.
• W2097125224 creator A5018649609 @default.
• W2097125224 creator A5030814682 @default.
• W2097125224 date "2013-10-10" @default.
• W2097125224 modified "2023-09-25" @default.
• W2097125224 title "Augmentation of Sensory-Evoked Hemodynamic Response in an Early Alzheimer's Disease Mouse Model" @default.
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• W2097125224 doi "https://doi.org/10.3233/jad-121900" @default.
• W2097125224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23948921" @default.
• W2097125224 hasPublicationYear "2013" @default.
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