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• W2097145245 abstract "The concentration and the distribution of lipids bound as lipoproteins in plasma are modified by gonadal hormones. The ingestion of estrogen in the form of ethinyl estradiol, estrone sulfate or diethylstilbestrol tends to correct the pathologic protein-lipid relationships of survivors of myocardial infarction, and in many instances accomplishes complete restoration of normal patterns. In primary hypercholesterolemic xanthomatosis the effect of estinyl is qualitatively similar but is not sufficient to restore normal patterns. In two cases of nephrosis chemical changes qualitatively similar to those observed in survivors of myocardial infarction were perceptible but were so small as to be therapeutically insignificant. Methyl testosterone exerts the opposite chemical effect. It exaggerates the chemical pathology of survivors of myocardial infarction and can produce abnormalities in plasma protein-lipid relationships of individuals whose protein-lipid patterns have been previously normal. When the estrogenic and androgenic hormones are given simultaneously, estrogenic effects are modified or obliterated. It has not been definitely demonstrated that the actions of testosterone are modified by estrogen. The experiments demonstrate that lipoproteins are subject to chemical manipulation but do not explain the mechanisms by which gonadal hormones operate. These observations appear to have possible significance in the pathogenesis of atherosclerosis. They indicate a chemical reason for the relative immunity of young women to the complications of atherosclerosis. They suggest that the action of estrogenic substances in atherosclerotic persons exhibiting striking protein-lipid abnormalities might be beneficial. They suggest that the use of methyl testosterone in such patients might be detrimental. While the observations have certain therapeutic implications, they indicate side actions which will make the use of estrogens unacceptable to many patients. It is clearly established that the administration of these hormones eliminates chemical abnormalities which may be regarded as detrimental; however, more extensive clinical studies will be necessary before estrogens can be considered useful in the prevention of atherosclerosis or in the treatment of its complications." @default.
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• W2097145245 date "1955-07-01" @default.
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• W2097145245 title "Influence of gonadal hormones on protein-lipid relationships in human plasma" @default.
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• W2097145245 doi "https://doi.org/10.1016/0002-9343(55)90270-9" @default.
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