FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097148145> ?p ?o ?g. }

• W2097148145 endingPage "1091" @default.
• W2097148145 startingPage "1083" @default.
• W2097148145 abstract "Background. Ceftriaxone is the foundation of currently recommended gonorrhea treatment. There is an urgent need for backup treatment options for patients with cephalosporin allergy or infections due to suspected cephalosporin-resistant Neisseria gonorrhoeae. We evaluated the efficacy and tolerability of 2 combinations of existing noncephalosporin antimicrobials for treatment of patients with urogenital gonorrhea. Methods. We conducted a randomized, multisite, open-label, noncomparative trial in 5 outpatient sexually transmitted disease clinic sites in Alabama, California, Maryland, and Pennsylvania. Patients aged 15–60 years diagnosed with uncomplicated urogenital gonorrhea were randomly assigned to either gentamicin 240 mg intramuscularly plus azithromycin 2 g orally, or gemifloxacin 320 mg orally plus azithromycin 2 g orally. The primary outcome was microbiological cure of urogenital infections (negative follow-up culture) at 10–17 days after treatment among 401 participants in the per protocol population. Results. Microbiological cure was achieved by 100% (lower 1-sided exact 95% confidence interval [CI] bound, 98.5%) of 202 evaluable participants receiving gentamicin/azithromycin, and 99.5% (lower 1-sided exact 95% CI bound, 97.6%) of 199 evaluable participants receiving gemifloxacin/azithromycin. Gentamicin/azithromycin cured 10 of 10 pharyngeal infections and 1 of 1 rectal infection; gemifloxacin/azithromycin cured 15 of 15 pharyngeal and 5 of 5 rectal infections. Gastrointestinal adverse events were common in both arms. Conclusions. Gentamicin/azithromycin and gemifloxacin/azithromycin were highly effective for treatment of urogenital gonorrhea. Gastrointestinal adverse events may limit routine use. These non-cephalosporin-based regimens may be useful alternative options for patients who cannot be treated with cephalosporin antimicrobials. Additional treatment options for gonorrhea are needed. Clinical Trials Registration. NCT00926796." @default.
• W2097148145 created "2016-06-24" @default.
• W2097148145 creator A5000182284 @default.
• W2097148145 creator A5000628207 @default.
• W2097148145 creator A5002513999 @default.
• W2097148145 creator A5004036580 @default.
• W2097148145 creator A5012326748 @default.
• W2097148145 creator A5012350344 @default.
• W2097148145 creator A5012691241 @default.
• W2097148145 creator A5013243426 @default.
• W2097148145 creator A5013684022 @default.
• W2097148145 creator A5017779608 @default.
• W2097148145 creator A5021837739 @default.
• W2097148145 creator A5032048298 @default.
• W2097148145 creator A5033282986 @default.
• W2097148145 creator A5034717763 @default.
• W2097148145 creator A5040574411 @default.
• W2097148145 creator A5041850725 @default.
• W2097148145 creator A5045328465 @default.
• W2097148145 creator A5045698591 @default.
• W2097148145 creator A5049073633 @default.
• W2097148145 creator A5051407280 @default.
• W2097148145 creator A5054289124 @default.
• W2097148145 creator A5055249273 @default.
• W2097148145 creator A5056409417 @default.
• W2097148145 creator A5058595385 @default.
• W2097148145 creator A5059367411 @default.
• W2097148145 creator A5062933534 @default.
• W2097148145 creator A5065616250 @default.
• W2097148145 creator A5066486945 @default.
• W2097148145 creator A5069207241 @default.
• W2097148145 creator A5073184586 @default.
• W2097148145 creator A5073461697 @default.
• W2097148145 creator A5074985927 @default.
• W2097148145 creator A5076161730 @default.
• W2097148145 creator A5078286112 @default.
• W2097148145 creator A5084685548 @default.
• W2097148145 creator A5085338548 @default.
• W2097148145 creator A5085538773 @default.
• W2097148145 creator A5086741564 @default.
• W2097148145 creator A5087357546 @default.
• W2097148145 creator A5088599901 @default.
• W2097148145 creator A5012347265 @default.
• W2097148145 date "2014-07-16" @default.
• W2097148145 modified "2023-10-17" @default.
• W2097148145 title "The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea" @default.
• W2097148145 cites W136212203 @default.
• W2097148145 cites W1971799109 @default.
• W2097148145 cites W1982392457 @default.
• W2097148145 cites W1983119654 @default.
• W2097148145 cites W1986207284 @default.
• W2097148145 cites W1990437922 @default.
• W2097148145 cites W1990608175 @default.
• W2097148145 cites W1990616737 @default.
• W2097148145 cites W1999272737 @default.
• W2097148145 cites W2007890363 @default.
• W2097148145 cites W2011544609 @default.
• W2097148145 cites W2013981975 @default.
• W2097148145 cites W2046937400 @default.
• W2097148145 cites W2051311583 @default.
• W2097148145 cites W2064915358 @default.
• W2097148145 cites W2066364915 @default.
• W2097148145 cites W2085652696 @default.
• W2097148145 cites W2093599231 @default.
• W2097148145 cites W2103270957 @default.
• W2097148145 cites W2104419918 @default.
• W2097148145 cites W2123386797 @default.
• W2097148145 cites W2144552450 @default.
• W2097148145 cites W2166836200 @default.
• W2097148145 cites W4323874733 @default.
• W2097148145 doi "https://doi.org/10.1093/cid/ciu521" @default.
• W2097148145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4271098" @default.
• W2097148145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25031289" @default.
• W2097148145 hasPublicationYear "2014" @default.
• W2097148145 type Work @default.
• W2097148145 sameAs 2097148145 @default.
• W2097148145 citedByCount "123" @default.
• W2097148145 countsByYear W20971481452014 @default.
• W2097148145 countsByYear W20971481452015 @default.
• W2097148145 countsByYear W20971481452016 @default.
• W2097148145 countsByYear W20971481452017 @default.
• W2097148145 countsByYear W20971481452018 @default.
• W2097148145 countsByYear W20971481452019 @default.
• W2097148145 countsByYear W20971481452020 @default.
• W2097148145 countsByYear W20971481452021 @default.
• W2097148145 countsByYear W20971481452022 @default.
• W2097148145 countsByYear W20971481452023 @default.
• W2097148145 crossrefType "journal-article" @default.
• W2097148145 hasAuthorship W2097148145A5000182284 @default.
• W2097148145 hasAuthorship W2097148145A5000628207 @default.
• W2097148145 hasAuthorship W2097148145A5002513999 @default.
• W2097148145 hasAuthorship W2097148145A5004036580 @default.
• W2097148145 hasAuthorship W2097148145A5012326748 @default.
• W2097148145 hasAuthorship W2097148145A5012347265 @default.
• W2097148145 hasAuthorship W2097148145A5012350344 @default.
• W2097148145 hasAuthorship W2097148145A5012691241 @default.
• W2097148145 hasAuthorship W2097148145A5013243426 @default.
• W2097148145 hasAuthorship W2097148145A5013684022 @default.

• next