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- W2097151520 endingPage "R68" @default.
- W2097151520 startingPage "R58" @default.
- W2097151520 abstract "This study examined the effects of chronic blockade of the renal formation of epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid with 1-aminobenzotriazole (ABT; 50 mg.kg(-1). day(-1) ip for 5 days) on pressure natriuresis and the inhibitory effects of elevations in renal perfusion pressure (RPP) on Na(+)-K(+)-ATPase activity and the distribution of the sodium/hydrogen exchanger (NHE)-3 in the proximal tubule of rats. In control rats (n = 15), sodium excretion rose from 2.3 +/- 0.4 to 19.4 +/- 1.8 microeq.min(-1).g kidney weight(-1) when RPP was increased from 114 +/- 1 to 156 +/- 2 mmHg. Fractional excretion of lithium rose from 28 +/- 3 to 43 +/- 3% of the filtered load. Chronic treatment of the rats with ABT for 5 days (n = 8) blunted the natriuretic response to elevations in RPP by 75% and attenuated the increase in fractional excretion of lithium by 45%. In vehicle-treated rats, renal Na(+)-K(+)-ATPase activity fell from 31 +/- 5 to 19 +/- 2 micromol P(i).mg protein(-1).h(-1) and NHE-3 protein was internalized from the brush border of the proximal tubule after an elevation in RPP. In contrast, Na(+)-K(+)-ATPase activity and the distribution of NHE-3 protein remained unaltered in rats treated with ABT. These results suggest that cytochrome P-450 metabolites of arachidonic acid contribute to pressure natriuresis by inhibiting Na(+)-K(+)-ATPase activity and promoting internalization of NHE-3 protein from the brush border of the proximal tubule." @default.
- W2097151520 created "2016-06-24" @default.
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- W2097151520 date "2004-07-01" @default.
- W2097151520 modified "2023-10-13" @default.
- W2097151520 title "Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis" @default.
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- W2097151520 cites W2203979713 @default.
- W2097151520 cites W2210723768 @default.
- W2097151520 cites W2215440944 @default.
- W2097151520 cites W2215884928 @default.
- W2097151520 cites W2220987992 @default.
- W2097151520 cites W2256153871 @default.
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- W2097151520 cites W2283724467 @default.
- W2097151520 cites W2290768171 @default.
- W2097151520 cites W2291127261 @default.
- W2097151520 cites W2318999834 @default.
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- W2097151520 doi "https://doi.org/10.1152/ajpregu.00713.2003" @default.
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- W2097151520 hasPublicationYear "2004" @default.
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