Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097151900> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2097151900 endingPage "443" @default.
- W2097151900 startingPage "437" @default.
- W2097151900 abstract "This paper describes the interaction of apamin, the bee venom neurotoxin, with its receptor in the guinea pig colon. The pharmacological activity of the toxin was assayed by measuring its contracting effect on guinea pig colon preparations that had been previously relaxed by neurotensin. The IC50 value of apamin in this in vitro bioassay is 7 nM. These pharmacological data are compared to the binding properties of apamin to smooth muscle membranes prepared from guinea pig colon. The highly radiolabeled monoiododerivative of apamin binds to its colon receptor with a dissociation constant Kd* = 36 pM. The maximal binding capacity of colonic membranes is 30dfmol/mg of protein. The dissociation constant of the unmodified toxin is 23 pM. The difference between the toxin concentrations that produce half-maximal effects in the binding and pharmacological studies arises from the different experimental conditions used for the two assays." @default.
- W2097151900 created "2016-06-24" @default.
- W2097151900 creator A5033079595 @default.
- W2097151900 creator A5045144996 @default.
- W2097151900 creator A5064226857 @default.
- W2097151900 creator A5068045779 @default.
- W2097151900 creator A5077277067 @default.
- W2097151900 creator A5088188549 @default.
- W2097151900 date "1982-08-01" @default.
- W2097151900 modified "2023-10-11" @default.
- W2097151900 title "Specific binding and pharmacological interactions of apamin, the neurotoxin from bee venom, with guinea pig colon" @default.
- W2097151900 cites W1572903046 @default.
- W2097151900 cites W1974220917 @default.
- W2097151900 cites W2006637507 @default.
- W2097151900 cites W2006710293 @default.
- W2097151900 cites W2008632682 @default.
- W2097151900 cites W2012907151 @default.
- W2097151900 cites W2030564203 @default.
- W2097151900 cites W2033003837 @default.
- W2097151900 cites W2040855617 @default.
- W2097151900 cites W2048646958 @default.
- W2097151900 cites W2079248432 @default.
- W2097151900 cites W2095587663 @default.
- W2097151900 doi "https://doi.org/10.1016/0024-3205(82)90328-9" @default.
- W2097151900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7132561" @default.
- W2097151900 hasPublicationYear "1982" @default.
- W2097151900 type Work @default.
- W2097151900 sameAs 2097151900 @default.
- W2097151900 citedByCount "48" @default.
- W2097151900 crossrefType "journal-article" @default.
- W2097151900 hasAuthorship W2097151900A5033079595 @default.
- W2097151900 hasAuthorship W2097151900A5045144996 @default.
- W2097151900 hasAuthorship W2097151900A5064226857 @default.
- W2097151900 hasAuthorship W2097151900A5068045779 @default.
- W2097151900 hasAuthorship W2097151900A5077277067 @default.
- W2097151900 hasAuthorship W2097151900A5088188549 @default.
- W2097151900 hasConcept C12554922 @default.
- W2097151900 hasConcept C134018914 @default.
- W2097151900 hasConcept C170493617 @default.
- W2097151900 hasConcept C185592680 @default.
- W2097151900 hasConcept C2776919887 @default.
- W2097151900 hasConcept C2777367657 @default.
- W2097151900 hasConcept C2778815084 @default.
- W2097151900 hasConcept C2780358027 @default.
- W2097151900 hasConcept C55493867 @default.
- W2097151900 hasConcept C74998103 @default.
- W2097151900 hasConcept C83743174 @default.
- W2097151900 hasConcept C86803240 @default.
- W2097151900 hasConcept C98274493 @default.
- W2097151900 hasConceptScore W2097151900C12554922 @default.
- W2097151900 hasConceptScore W2097151900C134018914 @default.
- W2097151900 hasConceptScore W2097151900C170493617 @default.
- W2097151900 hasConceptScore W2097151900C185592680 @default.
- W2097151900 hasConceptScore W2097151900C2776919887 @default.
- W2097151900 hasConceptScore W2097151900C2777367657 @default.
- W2097151900 hasConceptScore W2097151900C2778815084 @default.
- W2097151900 hasConceptScore W2097151900C2780358027 @default.
- W2097151900 hasConceptScore W2097151900C55493867 @default.
- W2097151900 hasConceptScore W2097151900C74998103 @default.
- W2097151900 hasConceptScore W2097151900C83743174 @default.
- W2097151900 hasConceptScore W2097151900C86803240 @default.
- W2097151900 hasConceptScore W2097151900C98274493 @default.
- W2097151900 hasIssue "5" @default.
- W2097151900 hasLocation W20971519001 @default.
- W2097151900 hasLocation W20971519002 @default.
- W2097151900 hasOpenAccess W2097151900 @default.
- W2097151900 hasPrimaryLocation W20971519001 @default.
- W2097151900 hasRelatedWork W1572728123 @default.
- W2097151900 hasRelatedWork W181238556 @default.
- W2097151900 hasRelatedWork W1977660378 @default.
- W2097151900 hasRelatedWork W2041656066 @default.
- W2097151900 hasRelatedWork W2074846829 @default.
- W2097151900 hasRelatedWork W2082321083 @default.
- W2097151900 hasRelatedWork W2087189215 @default.
- W2097151900 hasRelatedWork W2097151900 @default.
- W2097151900 hasRelatedWork W2375320432 @default.
- W2097151900 hasRelatedWork W979310981 @default.
- W2097151900 hasVolume "31" @default.
- W2097151900 isParatext "false" @default.
- W2097151900 isRetracted "false" @default.
- W2097151900 magId "2097151900" @default.
- W2097151900 workType "article" @default.